Physician
Hematology
Dr. Alan D. Schreiber, MD
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Alan D. Schreiber is an expert in the field of Hematology. He went to medical school at Albert Einstein College of Medicine of Yeshiva University. He received 1 awards: "Elected Member". Alan D. Schreiber is also published. He has 101 publications published. The lastest publication: "Fc gamma receptors in phagocytes.'
Publications
- Fc?RIIa requires lipid rafts, but not co-localization into rafts, for effector function.
- Effect of locally administered Syk siRNA on allergen-induced arthritis and asthma.
- Interaction of two phagocytic host defense systems: Fcγ receptors and complement receptor 3.
- Fcγ receptor I alpha chain (CD64) expression in macrophages is critical for the onset of meningitis by Escherichia coli K1.
- Differential requirement of lipid rafts for FcγRIIA mediated effector activities.
- Microtubules regulate PI-3K activity and recruitment to the phagocytic cup during Fcgamma receptor-mediated phagocytosis in nonelicited macrophages.
- Quantitative analysis of membrane remodeling at the phagocytic cup.
- Involvement of Syk kinase in TNF-induced nitric oxide production by airway epithelial cells.
- Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.
- Phosphorylation-independent ubiquitylation and endocytosis of Fc gammaRIIA.
- Role of ubiquitin and proteasomes in phagosome maturation.
- Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells.
- Association between monocyte Fcgamma subclass expression and acute coronary syndrome.
- Role for platelet-endothelial cell adhesion molecule-1 in macrophage Fcgamma receptor function.
- The monocyte Fcgamma receptors FcgammaRI/gamma and FcgammaRIIA differ in their interaction with Syk and with Src-related tyrosine kinases.
- Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria.
- Immune-mediated hemolytic anemia.
- Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change.
- The effect of phosphatases SHP-1 and SHIP-1 on signaling by the ITIM- and ITAM-containing Fcgamma receptors FcgammaRIIB and FcgammaRIIA.
- The carboxy-terminal region of the granulocyte colony-stimulating factor receptor transduces a phagocytic signal.
- Fcgamma receptor transmembrane domains: role in cell surface expression, gamma chain interaction, and phagocytosis.
- Signal sequence within Fc gamma RIIA controls calcium wave propagation patterns: apparent role in phagolysosome fusion.
- Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase.
- Differential role of actin, clathrin, and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosis.
- Enhanced phagocytosis through inhibition of de novo ceramide synthesis.
- Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.
- The CY domain of the Fcgamma RIa alpha-chain (CD64) alters gamma-chain tyrosine-based signaling and phagocytosis.
- Syntaxins 13 and 7 function at distinct steps during phagocytosis.
- Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase.
- Fc gamma receptors in phagocytes.
- Augmentation of pulmonary host defense against Pseudomonas by FcgammaRIIA cDNA transfer to the respiratory epithelium.
- Biological advances and clinical applications of Fc receptors for IgG.
- The immunobiology of human Fc gamma receptors on hematopoietic cells and tissue macrophages.
- Effect of endogenous and synthetic sex steroids on the clearance of antibody-coated cells.
- Receptors for the Fc portion of immunoglobulin G (Fc gamma R) on human monocytes and macrophages.
- Effect of danazol in immune thrombocytopenic purpura.
- Differential interleukin-1 elaboration by density-defined human monocyte subpopulations.
- Differential interleukin 1 elaboration by unfractionated and density fractionated human alveolar macrophages and blood monocytes: relationship to cell maturity.
- Isolation of cultured human monocytes/macrophages in suspension utilizing liquid and solid phase gelatin.
- The tumorigenic phenotype of a mutated form of Fc gamma RIIB1, lacking the ability to generate soluble receptor and allowing a low-level of ligand binding.
- The binding of monomeric IgG to human blood monocytes and alveolar macrophages.
- Modulation of macrophage Fc gamma receptors by rGM-CSF.
- Role for a glycan phosphoinositol anchor in Fc gamma receptor synergy.
- Hormonal modulation of macrophage clearance of IgG-sensitized cells.
- Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier.
- Potent growth inhibition of leukemic cells by novel ribbon-type antisense oligonucleotides to c-myb1.
- Impaired function of macrophage Fc gamma receptors and bacterial infection in alcoholic cirrhosis.
- B lymphocyte expression of a recognition locus for human monocytes and macrophages.
- Pulmonary defense mechanisms: modulation of Fc receptor activity in alveolar macrophages and other phagocytic cells by N-formyl peptides.
- Human monocyte recognition of complement-coated lymphoblastoid cells.
- Effect of antiplatelet antibody on platelet shape change, volume, and morphology.
- The Fc gamma receptors on human macrophages.
- In vivo glucocorticoid modulation of guinea pig splenic macrophage Fc gamma receptors.
- Effect of corticosteroids on the human monocyte IgG and complement receptors.
- Impaired function of macrophage Fc gamma receptors in end-stage renal disease.
- The role of antibody and complement in phagocytosis by rabbit alveolar macrophages.
- Role of antibody and complement in the immune clearance and destruction of erythrocytes. I. In vivo effects of IgG and IgM complement-fixing sites.
- Role of antibody and complement in the immune clearance and destruction of erythrocytes. II. Molecular nature of IgG and IgM complement-fixing sites and effects of the...
- The use of antibody-coated liposomes as a target cell model for antibody-dependent cell-mediated cytotoxicity.
- Serum lipids and arterial plaque load are altered independently with high-dose progesterone in hypercholesterolemic male rabbits.
- Effects of corticosteroids and splenectomy on the immune clearance and destruction of erythrocytes.
- Danazol treatment of myelodysplastic syndromes.
- Monocyte inhibition of lung fibroblast growth: relationship to fibroblast prostaglandin production and density-defined monocyte subpopulations.
- Differential prostaglandin production by unfractionated and density-fractionated human monocytes and alveolar macrophages.
- Effect of estradiol and steroid analogues on the clearance of immunoglobulin G-coated erythrocytes.
- Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies.
- Biochemical characterization of autologous fibrinogen adhesive.
- Effect of anti-P1A1 antibody on human platelets. I. The role of complement.
- Effect of heterologous antibody on human platelets.
- Acquired angioedema with lymphoproliferative disorder: association of C1 inhibitor deficiency with cellular abnormality.
- Pregnancy-associated thrombocytopenia: pathogenesis and management.
- Effect of heterologous antiplatelet antibody on human platelets: a new pathway to platelet alteration.
- Impaired granulocyte adherence in multiple myeloma: relationship to complement system, granulocyte delivery, and infection.
- Effect of anti-P1A1 antibody on human platelets. II. Mechanism of the complement-dependent release reaction.
- Effect of C3b inactivator on monocyte-bound C3-coated human erythrocytes.
- Effect of cytochalasin B on human monocyte binding and sphering of IgG-coated human erythrocytes.
- Effect of levamisole on the human monocyte IgG receptor.
- Granulocyte-associated IgG in neutropenic disorders.
- Human monocyte functional heterogeneity: monocyte fractionation by discontinuous albumin gradient centrifugation.
- Autoimmune hemolytic anemia.
- Low-titer cold-hemagglutinin disease. Mechanism of hemolysis and response to corticosteroids.
- Menstrual cyclic thrombocytopenia.
- Mutation induction by different types of radiation at the Hprt locus.
- Efficacy of intensive plasmapheresis in thrombotic thrombocytopenic purpura.
- Macrophage recognition of complement-coated lymphoblastoid cells.
- DR framework antigens and 63D3 antigens on human peripheral blood monocytes and alveolar macrophages.
- Platelet antibodies of the IgM class in immune thrombocytopenic purpura.
- Paroxysmal nocturnal hemoglobinuria revisited.
- The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor.
- Increased fluidity of human platelet membranes during complement-mediated immune platelet injury.
- Platelet FcgammaRIIA binds and internalizes IgG-containing complexes.
- Contrasting requirements for ubiquitylation during Fc receptor-mediated endocytosis and phagocytosis.
- Human platelet FcγRIIA and phagocytes in immune-complex clearance.
- Spleen tyrosine kinase (Syk) as a novel target for allergic asthma and rhinitis.
- The future of antisense oligonucleotides in the treatment of respiratory diseases.
- Differential expression of spleen tyrosine kinase Syk isoforms in tissues: Effects of the microbial flora.
- Antisense oligonucleotides to Syk kinase: a novel therapeutic approach for respiratory disorders.
- Aerosolized Syk antisense suppresses Syk expression, mediator release from macrophages, and pulmonary inflammation.
- Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides.
- The molecular dissection of Fc gamma receptor mediated phagocytosis.
Schools
Albert Einstein College of Medicine of Yeshiva University
North Carolina Memorial Hospital
R B Brigham Hospital Harvard
Doctors Specialties
- Internal Medicine
- Hematology
Accepted Insurances
Awards
- Elected Member
Education
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University of North Carolina Hospitals -
Albert Einstein College of Medicine of Yeshiva University
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