Clinical Fellow in Pediatrics, Boston Children's Hospital
Pediatric Hematology & Oncology
Dr. Alex Kentsis, MD
Doctor Alex Kentsis, MD is an expert in the field of Pediatric Hematology & Oncology. He researched medicine at Icahn School of Medicine at Mount Sinai. Icahn School of Medicine at Mount Sinai is ranked 20/62 in Research/PrimaryCare. Alex Kentsis, MD is a published physician as well. He has 28 publications published. The latest was: Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-Initiating cells engrafted into immunosuppressed NSG mice.
Publications
- Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-Initiating cells engrafted into immunosuppressed NSG mice.
- Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia.
- Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.
- KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute ...
- Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease.
- Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
- Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.
- Self-assembly properties of a model RING domain.
- Calculation of the free energy and cooperativity of protein folding.
- The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.
- Correspondence patterns: mechanisms and models of human dynamics.
- Further evidence that ribavirin interacts with eIF4E.
- Origin of the sequence-dependent polyproline II structure in unfolded peptides.
- Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain.
- Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.
- Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
- Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.
- Unfolded state of polyalanine is a segmented polyproline II helix.
- Physical mechanisms and biological significance of supramolecular protein self-assembly.
- Nedd8 on cullin: building an expressway to protein destruction.
- MC-PHS: a Monte Carlo implementation of the primary hydration shell for protein folding and design.
- Control of biochemical reactions through supramolecular RING domain self-assembly.
- The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.
- Challenges and opportunities for discovery of disease biomarkers using urine proteomics.
- Venous Thrombosis associated with gene deletion of tissue factor pathway inhibitor.
- Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry.
- Discordant haemophilia A in male siblings due to a de novo mutation on a familial missense mutant allele.
Schools
Mount Sinai School of Medicine
Children39s Hospital Boston
Conditions Treated
- Deep Vein Thrombosis (DVT)
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Education
-
Boston Children's Hospital -
Icahn School of Medicine at Mount Sinai
Hospital
-
NewYork-Presbyterian/Weill Cornell
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