Professor, Pediatrics, University of Cincinnati College of Medicine
Pediatric Hematology & Oncology
Dr. Alexandra H. Filipovich, MD
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Alexandra Filipovich practices Pediatric Hematology & Oncology. She graduated from University of Minnesota Medical School. University of Minnesota Medical School has a rank of 40 in research and a 10 in primary care Alexandra H. Filipovich is a published MD. She has 69 papers published. The most current publication "Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation."
Publications
- Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation.
- Pulmonary hypertension associated with bronchiolitis obliterans after hematopoietic stem cell transplantation.
- Activated phosphoinositide 3-kinase δ syndrome in a patient with a former diagnosis of common variable immune deficiency, bronchiectasis, and lymphoproliferative disease.
- A challenging undertaking: Stem cell transplantation for immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.
- Outcomes of donor lymphocyte infusion for treatment of mixed donor chimerism after a reduced-intensity preparative regimen for pediatric patients with nonmalignant dis...
- Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis.
- Reduced-Intensity Conditioning Hematopoietic Cell Transplantation Is an Effective Treatment for Patients with SLAM-Associated Protein Deficiency/X-linked Lymphoprolife...
- Synergistic defects of different molecules in the cytotoxic pathway lead to clinical familial hemophagocytic lymphohistiocytosis.
- Real-Time Detection of CTL Function Reveals Distinct Patterns of Caspase Activation Mediated by Fas versus Granzyme B.
- Non dermatomal rash and pancytopenia in a 5 year old child.
- Clinical flow cytometric screening of SAP and XIAP expression accurately identifies patients with SH2D1A and XIAP/BIRC4 mutations.
- The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients.
- The 253-kb inversion and deep intronic mutations in UNC13D are present in North American patients with familial hemophagocytic lymphohistiocytosis 3.
- An Intermediate Alemtuzumab Schedule Reduces the Incidence of Mixed Chimerism Following Reduced-Intensity Conditioning Hematopoietic Cell Transplantation for Hemophago...
- The natural history of children with severe combined immunodeficiency: baseline features of the first fifty patients of the primary immune deficiency treatment consort...
- Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis.
- Flow Cytometric Measurement of SLAM-Associated Protein and X-Linked Inhibitor of Apoptosis.
- Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis.
- Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes.
- Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab.
- Familial hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease.
- Expert Commentary: Practical Issues in Newborn Screening for Severe Combined Immune Deficiency (SCID).
- The expanding spectrum of hemophagocytic lymphohistiocytosis.
- Chemo-immunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol.
- Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial hemophagocytic lymphohistiocytosis.
- How we treat hemophagocytic lymphohistocytosis.
- Reduced-intensity conditioning haematopoietic cell transplantation for haemophagocytic lymphohistiocytosis: an important step forward.
- Hemophagocytosis causes a consumptive anemia of inflammation.
- Malignancies after hematopoietic cell transplantation for primary immune deficiencies: a report from the Center for International Blood and Marrow Transplant Research.
- Impaired immune function in children with Fanconi anaemia.
- Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis.
- Blood, and Not Urine, BK Viral Load Predicts Renal Outcome in Children with Hemorrhagic Cystitis following Hematopoietic Stem Cell Transplantation.
- Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplanta...
- Successful early intervention for hyperacute transplant-associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation.
- X-linked lymphoproliferative syndromes: brothers or distant cousins?
- XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative dise...
- STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.
- Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency.
- A rapid flow cytometric screening test for X-linked lymphoproliferative disease due to XIAP deficiency.
- Patients with X-linked lymphoproliferative disease due to BIRC4 mutation have normal invariant natural killer T-cell populations.
- Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment.
- Hemophagocytic lymphohistiocytosis (HLH) and related disorders.
- Allogeneic hematopoietic cell transplantation for primary immune deficiency diseases: current status and critical needs.
- Tumor immune surveillance defect of X-linked severe combined immunodeficiency is not Epstein-Barr virus specific.
- Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73: 147-157. 1993.
- Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels.
- Hemophagocytic lymphohistiocytosis and other hemophagocytic disorders.
- Adolescent presentation of x-linked lymphoproliferative disease.
- Cutaneous infection with Metarhizium anisopliae in a patient with hypohidrotic ectodermal dysplasia and immune deficiency.
- Mutations of the hemophagocytic lymphohistiocytosis-associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis.
- Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus.
- Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis.
- Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease: a mimicker of sepsis in the pediatric intensive care unit.
- HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.
- Hemophagocytic lymphohistiocytosis and related disorders.
- Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis.
- Patients of African ancestry with hemophagocytic lymphohistiocytosis share a common haplotype of PRF1 with a 50delT mutation.
- Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials...
- Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-v...
- Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.
- National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working grou...
- Healing hemophagocytosis.
- Two novel CHS1 (LYST) mutations: clinical correlations in an infant with Chediak-Higashi syndrome.
- Rapid detection of intracellular SH2D1A protein in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members.
- Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency.
- Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes.
- Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation.
- Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members.
Schools
University of Mn Med Sch
University Minn Hospital
Doctors Specialties
- Pediatrics
- Pediatric Hematology
- Oncology
Accepted Insurances
Education
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University of Minnesota at Fairview -
University of Minnesota Medical School
Hospital
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Cincinnati Children's Hospital Medical Center
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