Linde Family Professor of Medicine, Dana-Farber Cancer Institute
Oncology
Dr. Barrett J. Rollins, MD
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Barrett J. Rollins, MD is an expert in the field of Oncology. He studied medicine at Case Western Reserve University School of Medicine. He received awards:"Elected Member". Dr. Barrett J. Rollins is a published doctor and has 101 publications published. The lastest was: 'Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis.'
Publications
- Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.
- Ethnicity, race, and socioeconomic status influence incidence of langerhans cell histiocytosis.
- Prospective Enterprise-Level Molecular Genotyping of a Cohort of Cancer Patients.
- Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine.
- Somatic activating ARAF mutations in Langerhans cell histiocytosis.
- BRAF V600E-Positive Multisite Langerhans Cell Histiocytosis in a Preterm Neonate.
- Pathogenesis of langerhans cell histiocytosis.
- Recent advances in the understanding of Langerhans cell histiocytosis.
- Recurrent BRAF mutations in Langerhans cell histiocytosis.
- The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.
- Where the confusion began: cloning the first chemokine receptors.
- RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma.
- MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma.
- microRNA expression in the biology, prognosis, and therapy of Waldenström macroglobulinemia.
- CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.
- Innocents abroad: regulating where naive T cells go.
- Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.
- Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy.
- The chemokine decoy receptor M3 blocks CC chemokine ligand 2 and CXC chemokine ligand 13 function in vivo.
- Release the hounds! A chemokine elicits monocytes from bone marrow.
- The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection.
- Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2.
- CXC chemokine ligand 12 (stromal cell-derived factor 1 alpha) and CXCR4-dependent migration of CTLs toward melanoma cells in organotypic culture.
- Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice.
- CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts.
- The effect of MCP-1 depletion on chemokine and chemokine-related gene expression: evidence for a complex network in acute inflammation.
- Impairment in postischemic neovascularization in mice lacking the CXC chemokine receptor 3.
- The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation.
- Differential roles of CCL2 and CCR2 in host defense to coronavirus infection.
- MCP-1-dependent signaling in CCR2(-/-) aortic smooth muscle cells.
- CCL2 (monocyte chemoattractant protein-1) and cancer.
- Cyclin C/cdk3 promotes Rb-dependent G0 exit.
- Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells.
- Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent m...
- Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells.
- An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice.
- MCP-1 deficiency is associated with reduced intimal hyperplasia after arterial injury.
- CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-beta in high dose oral tolerance.
- Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies.
- Absence of CC chemokine ligand 2 results in an altered Th1/Th2 cytokine balance and failure to expel Trichuris muris infection.
- Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis.
- Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice.
- MCP-1 expression in endotoxin-induced uveitis.
- Coding SNPs included in exon arrays for the study of psychiatric disorders.
- Micronutrient assay for cancer prevention clinical trials: serum retinol, retinyl palmitate, alpha-carotene, and beta-carotene with the use of high-performance liquid ...
- Preliminary characterization of the proteoglycans in the substrate adhesion sites of normal and virus-transformed murine cells.
- Glycosaminoglycans in the substrate adhesion sites of normal and virus-transformed murine cells.
- A novel p16INK4A transcript.
- Fibronectin and proteoglycans as determinants of cell-substratum adhesion.
- Two functionally distinct pools of glycosaminoglycan in the substrate adhesion site of murine cells.
- p16INK4A as a human tumor suppressor.
- p16INK4A participates in a G1 arrest checkpoint in response to DNA damage.
- Serum-inducible genes.
- Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors.
- High level expression of human MCP-1 using the LCR/MEL expression system.
- Platelet-derived growth factor generates at least two distinct intracellular signals that modulate gene expression.
- Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties.
- Molecular regulation of growth control: implications for wound healing.
- Monocyte chemotactic protein gene expression by cytokine-treated human retinal pigment epithelial cells.
- Targeted expression of chemokines in vivo.
- If it's Tuesday, this must be a Belgian chemokine.
- Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice.
- Physiological coreceptor use by dual-tropic HIV-1: one plus one equals one.
- Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice.
- Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein-1 expression from human pulmonary type II-like epithelial cells.
- Human keratinocyte growth-promoting activity on the surface of fibroblasts.
- The physiology of p16(INK4A)-mediated G1 proliferative arrest.
- Mutation analysis of glial cell line-derived neurotrophic factor, a ligand for an RET/coreceptor complex, in multiple endocrine neoplasia type 2 and sporadic neuroendo...
- Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.
- Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus.
- Chemokines and atherosclerosis: what Adam Smith has to say about vascular disease.
- Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA.
- Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells.
- Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.
- The human homolog of the JE gene encodes a monocyte secretory protein.
- A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor.
- MCP-1 expression by rat type II alveolar epithelial cells in primary culture.
- Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.
- "Oh, no. Not another cytokine."--MCP-1 and respiratory disease.
- Comparison of fibroblast and T-cell activation genes.
- JE/MCP-1: an early-response gene encodes a monocyte-specific cytokine.
- Chemokines.
- A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer.
- Human fibroblasts express functional IL-2 receptors formed by the IL-2R alpha- and beta-chain subunits: association of IL-2 binding with secretion of the monocyte chem...
- Platelet-derived growth factor regulates glucose transporter expression.
- Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.
- Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis.
- Structure/activity analysis of human monocyte chemoattractant protein-1 (MCP-1) by mutagenesis. Identification of a mutated protein that inhibits MCP-1-mediated monocy...
- Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice.
- Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors.
- Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease.
- In vivo and in vitro inhibition of JE gene expression by glucocorticoids.
- A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer.
- Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines.
- Expression of cytokine-like genes JE and KC is increased during renal ischemia.
- Monocyte chemoattractant protein-1.
- Environment-dependent growth inhibition of human epidermal keratinocytes by recombinant human transforming growth factor-beta.
- MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B.
- Monocyte chemoattractant protein-1 gene is expressed in activated neutrophils and retinoic acid-induced human myeloid cell lines.
- Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells.
Schools
Case Western Reserve University School of Medicine
Beth Israel Hospital Boston
Dana Farber Cancer Institute
Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
Awards
- Elected Member
Education
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Beth Israel Deaconess Medical Center -
Case Western Reserve University School of Medicine
Hospital
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Dana-Farber Cancer Institute
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