Associate Professor of Surgery, Massachusetts General Hospital
General Surgery
Dr. Bruce R. Rosengard, MD
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Bruce Rosengard works in the field of General Surgery. He researched medicine at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical university. Johns Hopkins University School of Medicine is ranked 3/29 in Research/PrimaryCare. He has 1 awards "Fellow (FACS)". Bruce Rosengard is a published doctor as well. He has 86 publications published. The latest was: Rescue photochemotherapy for the treatment of acute cardiac rejection in the absence of cyclosporine maintenance therapy.
Publications
- Donor Brain Death Inhibits Tolerance Induction in Miniature Swine Recipients of Fully MHC-Disparate Pulmonary Allografts.
- Autoimmune Sensitization to Cardiac Myosin Leads to Acute Rejection of Cardiac Allografts in Miniature Swine.
- Pattern specification and immune response transcriptional signatures of pericardial and subcutaneous adipose tissue.
- Immunosuppression for lung transplantation.
- Repetitive gastric aspiration leads to augmented indirect allorecognition after lung transplantation in miniature swine.
- Mechanisms of chronic rejection in cardiothoracic transplantation.
- Regulatory transplantation tolerance and "stemness": evidence that Foxp3 may play a regulatory role in SOCS-3 gene transcription.
- A systematic review of randomized trials comparing revascularization rate and graft patency of off-pump and conventional Coronary surgery.
- Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection.
- Fetal liver as a source of autologous progenitor cells for perinatal tissue engineering.
- Homeostatic proliferation is a barrier to transplantation tolerance.
- Clinical risk factors for primary graft Failure following lung transplantation.
- Hormonal resuscitation yields more transplanted Hearts, with improved early function.
- Temporal changes in left ventricular systolic function in Heart donors: results of serial echocardiography.
- Aggressive pharmacologic donor management results in more transplanted organs.
- Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion.
- Mechanism of T cell-mediated endothelial apoptosis.
- Left ventricular assist device for right side assistance in patients with transposition.
- Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28-29, 2001, Crystal City, Va.
- Cardiopulmonary bypass for bilateral sequential lung transplantation in patients with chronic obstructive pulmonary Disease without adverse effect on lung function or ...
- The role of passenger leukocyte genotype in rejection and acceptance of rat liver allografts.
- CD3 monitoring of antithymocyte globulin therapy in thoracic organ transplantation.
- Depletion of recipient CD4+ but not CD8+ T lymphocytes prevents the development of cardiac allograft vasculopathy.
- Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger Acute rejection: an alternative mechanism of allorecognition.
- A novel small animal model of left ventricular tissue engineering.
- Multiparameter flow cytometric approach for simultaneous evaluation of T lymphocyte-endothelial cell interactions.
- Transmission of donor cancer into cardiothoracic transplant recipients.
- Bronchogenic carcinoma complicating lung transplantation.
- Characteristics and outcomes of patients with sarcoidosis listed for lung transplantation.
- Application of "double bridge mechanical" resuscitation for profound cardiogenic shock leading to cardiac transplantation.
- Emergent lung retransplantation after discovery of two primary malignancies in the donor.
- Successful experience with simultaneous lung volume reduction and cardiac procedures.
- A simple method for culturing mouse vascular endothelium.
- Simultaneous blockade of B7-CD28 and CD40-CD40L costimulation eliminates the direct xenorestricted human anti-porcine T-cell response.
- Third-party passenger leukocytes prolong liver allograft survival.
- Mechanical cardiac support 2000: current applications and future trial design: June 15-16, 2000 Bethesda, Maryland.
- Bilateral versus single lung transplantation for chronic obstructive pulmonary Disease: intermediate-term results.
- Mechanical cardiac support 2000: current applications and future trial design. June 15-16, 2000 Bethesda, Maryland.
- The tolerant recipient: looking great in someone else's genes.
- Donor antigen-presenting cells are important in the development of obliterative airway Disease.
- Immune monitoring in xenotransplantation: the multiparameter flow cytometric mixed lymphocyte culture assay.
- Replacement of graft-resident donor-type antigen presenting cells alters the tempo and pathogenesis of murine cardiac allograft rejection.
- Allosensitization increases human anti-pig cellular xenoreactivity.
- Detection of anti-HLA antibody by flow cytometry in patients with a left ventricular assist device is associated with early rejection following Heart transplantation.
- Persistence of donor antigen is necessary for maintenance of xenotolerance--a parallel to allogeneic systems.
- Tolerance of rat cardiac allografts does not require donor-type "passenger" antigen presenting cells.
- Hearts lacking donor-type APCs develop cardiac allograft vasculopathy.
- Rescue photochemotherapy for the treatment of Acute cardiac rejection in the absence of cyclosporine maintenance therapy.
- Effect of volume reduction on lung transplant timing and selection for chronic obstructive pulmonary Disease.
- Thoracoscopic management of descending necrotizing mediastinitis.
- Creation of chimeric Hearts: a tool for testing the "passenger leukocyte" hypothesis.
- Bilateral versus single lung transplantation for chronic obstructive pulmonary Disease.
- Aortic Dissection in a cardiac allograft recipient: a case report.
- Effect of tolerance to allogeneic major histocompatibility complex antigens on rejection across minor antigen differences.
- Interleukin-2 reverses the ability of cyclosporine to induce tolerance to class I disparate kidney allografts in miniature swine.
- Development of tolerance to class II-mismatched renal transplants after a short course of cyclosporine therapy in miniature swine.
- Retransplantation in miniature swine. Lack of a requirement for graft adaptation for maintenance of specific renal allograft tolerance.
- The uses of molecular biology in transplantation.
- Tolerance to class I-disparate renal allografts in miniature swine. Maintenance of tolerance despite induction of specific antidonor CTL responses.
- In vivo treatment with monoclonal antibodies directed against CD4 and CD8 antigens in miniature swine.
- Complement-mediated cytolysis: a quick, simple method for determining levels of immunoglobulin E bound to mast cells.
- Fatal disseminated candidiasis due to amphotericin-B-resistant Candida guilliermondii.
- Effects of cyclosporine, aspirin, and cobra venom factor on discordant cardiac xenograft survival in rats.
- Differences in the pathogenesis of first-set allograft rejection and Acute xenograft rejection as determined by sequential morphologic analysis.
- Mast cell secretion: differences between immunologic and non-immunologic stimulation.
- Transplantation in miniature swine: analysis of graft-infiltrating lymphocytes provides evidence for local suppression.
- The first basic sciences symposium of the Transplantation Society.
- Prostaglandin E2 inhibits in vitro and in vivo lymphocyte responses in allogeneic transplantation.
- Induction of kidney transplantation tolerance across major histocompatibility complex barriers by bone marrow transplantation in miniature swine.
- The effects of recombinant human IL-2 in miniature swine.
- Renal transplantation in miniature swine: preliminary evidence that graft infiltrating leukocytes suppress donor-specific cell-mediated lymphocytotoxicity in co-culture.
- New approaches to transplantation tolerance.
- In vitro studies involving APC-depleted responder cells suggest the existence of a CD8+ direct recognition pathway in miniature swine.
- The Failure of skin grafting to break tolerance to class I-disparate renal allografts in miniature swine despite inducing marked antidonor cellular immunity.
- Selective breeding of miniature swine leads to an increased rate of acceptance of MHC-identical, but not of class I-disparate, renal allografts.
- Successful induction of long-term specific tolerance to fully allogeneic renal allografts in miniature swine.
- Induction of specific tolerance to class I-disparate renal allografts in miniature swine with cyclosporine.
- Increased transplanted organs from the use of a standardized donor management protocol.
- Report of the Crystal City meeting to maximize the use of organs recovered from the cadaver donor.
- Thoracic transplantation.
- Myocardial tissue engineering and regeneration as a therapeutic alternative to transplantation.
- Surrogate markers and risk factors for chronic lung allograft dysfunction.
- Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance.
- In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3.
- The indirect alloresponse impairs the induction but not maintenance of tolerance to MHC class I-disparate allografts.
Schools
Johns Hopkins University School of Medicine
Johns Hopkins Hospital
NciNih
Papworth Hospital
Procedures Preformed
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac MRI (Magnetic Resonance Imaging) of Heart or Chest
- Carotid Endarterectomy (CEA) or Excision of Infected Graft
- Chest CT (incl. Heart and Lungs)
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Conditions Treated
- Aneurysm and Dissection of Heart
- Angina and Acute Coronary Syndrome
- Aortic Ectasia
- Aortic Embolism and Thrombosis
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Doctors Specialties
- Cardiac Surgery
- Critical Care Surgery
- General Surgery
Accepted Insurances
Awards
- Fellow (FACS)
Education
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Johns Hopkins University -
Johns Hopkins University School of Medicine
Hospital
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Massachusetts General Hospital
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