Professor of Pediatrics, University Pennsylvania
Pediatric Hematology & Oncology
Dr. Carolyn A. Felix, MD
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Carolyn Felix practices Pediatric Hematology & Oncology. She attended Boston University School of Medicine. Boston University School of Medicine has a rank of 30 in research and a 52 in primary care She received 4 awards: "America's Top Doctors", "America's Top Doctors for Cancer", "Philadelphia Magazine" and "Super Doctor". Carolyn Felix is a published doctor and has 93 publications published. The lastest was: 'Association of CYP3A4 genotype with treatment-related leukemia.'
Publications
- Intensified chemotherapy without SCT in infant ALL: Results from COG P9407 (Cohort 3).
- Topoisomerase II and leukemia.
- Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia (ALL).
- Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.
- Infant leukemia 2010: a call to action for the west and the "four Asian Tigers".
- Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia.
- A safer regimen for high-risk neuroblastoma.
- Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences.
- Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis.
- Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome.
- Proteomics-based strategy to identify biomarkers and pharmacological targets in leukemias with t(4;11) translocations.
- BglII-based panhandle and reverse panhandle PCR approaches increase capability for cloning der(II) and der(other) genomic breakpoint junctions of MLL translocations.
- Development of cold agglutinin autoimmune hemolytic anemia during treatment for pediatric acute lymphoblastic leukemia.
- DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
- Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion.
- Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group.
- Kinetics and regulation of cytochrome P450-mediated etoposide metabolism.
- 1,4-Benzoquinone is a topoisomerase II poison.
- Plasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide.
- The molecular basis of leukemia.
- Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children.
- Isolated extramedullary relapse in acute myeloid leukemia: A retrospective analysis.
- p53 mutations in leukemia and myelodysplastic syndrome after ovarian cancer.
- Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of M...
- Pediatric Acute Lymphoblastic Leukemia: Challenges and Controversies in 2000.
- IL-2-dependent expansion of CD3+ large granular lymphocytes expressing T cell receptor-gamma delta. Evidence for a functional receptor by anti-CD3 activation of cytoly...
- Metoclopramide as an antiemetic agent in pediatric oncology patients.
- NOX 100, a nitric oxide scavenger, enhances cardiac allograft survival and promotes long-term graft acceptance.
- Detection of germinal mosaicism in a DMD family.
- Assessment of chromosome 3 copy number in ocular melanoma using fluorescence in situ hybridization.
- Stimulation of the beta-subunit of the IL-2 receptor induces MHC-unrestricted cytotoxicity in T acute lymphoblastic leukemia cells and normal thymocytes.
- [Mediastinitis after cardiac surgery. A 10-year evaluation (1985-1995)].
- Avascular necrosis of bone following combination chemotherapy for acute lymphocytic leukemia.
- Etoposide and Langerhans cell histiocytosis: second malignancies, a second look.
- High incidence of secondary brain tumours after radiotherapy and antimetabolites.
- Massive acute hemolysis secondary to Clostridium perfringens sepsis in a recently transfused oncology patient with multiple alloantibodies.
- Characterization of acute lymphoblastic leukemia of childhood by immunoglobulin and T-cell receptor gene patterns.
- Characterization of the breakpoint of a t(14;14)(q11.2;q32) from the leukemic cells of a patient with T-cell acute lymphoblastic leukemia.
- Overexpression of p53 protein in cutaneous T cell lymphoma: relationship to large cell transformation and disease progression.
- Complex replication error causes p53 mutation in a Li-Fraumeni family.
- T cell receptor alpha-, beta-, and gamma-genes in T cell and pre-B cell acute lymphoblastic leukemia.
- Granulocytic sarcoma.
- Molecular pathogenesis of secondary acute promyelocytic leukemia.
- Secondary leukemias induced by topoisomerase-targeted drugs.
- Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma.
- Absence of hereditary p53 mutations in 10 familial leukemia pedigrees.
- Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.
- Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
- A novel germline p53 splicing mutation in a pediatric patient with a second malignant neoplasm.
- Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.
- Polymorphism at codon 36 of the p53 gene.
- Acute differentiated dendritic cell leukemia: a variant form of pediatric acute myeloid leukemia with MLL translocation.
- Evidence of early start for common acute lymphoblastic leukaemia.
- Panhandle PCR: a technical advance to amplify MLL genomic translocation breakpoints.
- Leukemia in infants.
- The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion.
- Immunoglobulin and T cell receptor gene configuration in acute lymphoblastic leukemia of infancy.
- Differentiation stages of childhood acute lymphoblastic leukemias with p53 mutations.
- Identification of an altered immunoglobulin heavy-chain gene rearrangement in the central nervous system in B-precursor acute lymphoblastic leukemia.
- Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignancies.
- Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia.
- ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.
- Sequential development of Wilms tumor, T-cell acute lymphoblastic leukemia, medulloblastoma and myeloid leukemia in a child with type 1 neurofibromatosis: a clinical a...
- Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations.
- Leukemias related to treatment with DNA topoisomerase II inhibitors.
- RAS mutations in pediatric leukemias with MLL gene rearrangements.
- Maternal hemoglobin concentration during pregnancy and risk of infant leukaemia: a children''s oncology group study.
- Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites.
- Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry.
- Association of CYP3A4 genotype with treatment-related leukemia.
- MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children.
- Duplicated regions of AF-4 intron 4 at t(4;11) translocation breakpoints.
- Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia.
- p53 gene mutations in pediatric brain tumors.
- Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphobla...
- Association of germline p53 mutation with MLL segmental jumping translocation in treatment-related leukemia.
- t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velo...
- Potential role for wild-type p53 in leukemias with MLL gene translocations.
- Panhandle polymerase chain reaction amplifies MLL genomic translocation breakpoint involving unknown partner gene.
- Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias.
- The p53 gene in pediatric therapy-related leukemia and myelodysplasia.
- Clonal expansion of germline B-lineage acute lymphoblastic leukemia in severe combined immunodeficient mice.
- Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints.
- t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene.
- Panhandle PCR for cDNA: a rapid method for isolation of MLL fusion transcripts involving unknown partner genes.
- Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.
- MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia,...
- Reciprocal DNA topoisomerase II cleavage events at 5''-TATTA-3'' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and ...
- Topoisomerase II and the etiology of chromosomal translocations.
- Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450.
- Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation.
- mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues.
Schools
Boston University School Of Medicine
Chldns Hospital Pittsburgh
Nci Ped Br
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- America's Top Doctors
- America's Top Doctors for Cancer
- Philadelphia Magazine
- Super Doctor
Education
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National Institutes of Health Clinical Center -
University of Pittsburgh Medical Center -
Boston University School of Medicine
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