Associate Professor, Medicine, Tufts Medical Center

Infectious Disease

Cheleste Thorpe works in the field of Infectious Disease. She graduated from Tufts University School of Medicine. Tufts University School of Medicine is ranked 49/52 in Research/PrimaryCare. Cheleste M. Thorpe, MD is also a published MD. She has 29 paper published. The most recent paper is: A US Based National Sentinel Surveillance Study for the Epidemiology of Clostridium difficile Associated Diarrheal Isolates and their Susceptibility to Fidaxomicin. She accepts Medicare payments and is registered with Medicare.gov.

Publications

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• A US Based National Sentinel Surveillance Study for the Epidemiology of Clostridium difficile Associated Diarrheal Isolates and their Susceptibility to Fidaxomicin.
• The Effects of Shiga Toxin Type 2 on a Bioengineered 3D Model of Human Renal Tissue.
• Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin.
• Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction.
• Tissue factor–dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli.
• Shiga toxin 2 and flagellin from shiga-toxigenic Escherichia coli superinduce interleukin-8 through synergistic effects on host stress-activated protein kinase activat...
• Prevalence of the operon encoding subtilase cytotoxin in non-O157 Shiga toxin-producing Escherichia coli isolated from humans in the United States.
• The emerging clinical importance of non-O157 Shiga toxin-producing Escherichia coli.
• Update on Clostridium difficile.
• Borrelia burgdorferi-induced expression of matrix metalloproteinases from human chondrocytes requires mitogen-activated protein kinase and Janus kinase/signal transduc...
• Shiga toxin-producing Escherichia coli infection.
• Critical roles for stx2, eae, and tir in enterohemorrhagic Escherichia coli-induced diarrhea and intestinal inflammation in infant rabbits.
• Shiga toxin 1 triggers a ribotoxic stress response leading to p38 and JNK activation and induction of apoptosis in intestinal epithelial cells.
• Shiga toxin interactions with the intestinal epithelium.
• Shiga toxins activate translational regulation pathways in intestinal epithelial cells.
• The operon encoding SubAB, a novel cytotoxin, is present in shiga toxin-producing Escherichia coli isolates from the United States.
• Testing of urinary Escherichia coli isolates for Shiga toxin production.
• Shiga toxins do not directly stimulate alpha-granule secretion or enhance aggregation of human platelets.
• Shiga toxin translocation across intestinal epithelial cells is enhanced by neutrophil transmigration.
• Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNAs in intestinal epithelial cells, resulting in increased chemokine expression.
• Shiga toxins 1 and 2 translocate differently across polarized intestinal epithelial cells.
• Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells.
• Expression of the highly polymorphic Cryptosporidium parvum Cpgp40/15 gene in genotype I and II isolates.
• AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.
• Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways.
• ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression.
• Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB5 toxin that targets the endoplasmic reticulum chaperone BiP.
• Shiga toxin-producing Escherichia coli infection in South India.

Schools

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• Tufts University

• New England Med Center Hosps

• Tufts Med Center

Doctors Specialties

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• Infectious Disease Medicine
• Infectious Disease

Accepted Insurances

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Education

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• Tufts Medical Center
• Tufts University School of Medicine

Hospital

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• Tufts Medical Center

Drug Facts

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NPI NUMBER		1356385850
NPPES Provider LastName		THORPE
NPPES Provider FirstName		CHELESTE
NPPES Provider ZIPCode		021111526
NPPES Provider State		MA
Specialty Description		Infectious Disease
Total Claim Count		51.0
Distinct Opioid Count		0.0
Opioid Claim Count		0.0
Percent Opioid Claims		0.0

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1356385850
Last Name Of The Provider	THORPE
First Name Of The Provider	CHELESTE
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