Physician
Rheumatology
Dr. Christopher J. Froelich, MD
|
|
Give Review
Doctor Christopher J. Froelich, MD is an expert in the field of Rheumatology. He attended Loyola University Chicago Stritch School of Medicine. He received 2 awards: "CMS Meaningful Use Stage 1 Certification" and "Fellow (FACR)". Christopher Froelich has written publications. He has 101 publications published with PubMed. The lastest paper is: 'BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.'
Publications
- Mouse Cytotoxic T Cell-derived Granzyme B Activates the Mitochondrial Cell Death Pathway in a Bim-dependent Fashion.
- Perforin oligomers form arcs in Cellular membranes: a locus for intraCellular delivery of granzymes.
- Elucidating Sources and Roles of Granzymes A and B during Bacterial Infection and Sepsis.
- Granzyme A Produced by ?(9)?(2) T Cells Induces Human Macrophages to Inhibit Growth of an IntraCellular Pathogen.
- Perforin activity at membranes leads to invaginations and vesicle formation.
- Human perforin employs different avenues to damage membranes.
- Perforin rapidly induces plasma membrane phospholipid flip-flop.
- Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage.
- Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T Cells modifies cytoskeleton dynamics.
- Granzyme A is a proinflammatory protease.
- Human and mouse granzyme A induce a proinflammatory cytokine response.
- Granzyme B translocates across the lipid membrane only in the presence of lytic agents.
- NK Cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.
- Modulation of the tumor Cell phenotype by IFN-gamma results in resistance of uveal melanoma Cells to granule-mediated lysis by cytotoxic lymphocytes.
- Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected Cells.
- ExtraCellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.
- A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target Cells.
- SPI-CI and SPI-6 cooperate in the protection from effector Cell-mediated cytotoxicity.
- Myeloma Cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes.
- A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory Cell homeostasis.
- Human neutrophils lack granzyme A, granzyme B, and perforin.
- Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.
- Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target Cells.
- Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage.
- Right place, right time.
- Pit Cells exclusively kill P815 tumor Cells by the perforin/granzyme pathway.
- Lack of the CD8+ Cell anti-HIV factor in CD8+ Cell granules.
- The human cytomegalovirus protein UL16 mediates increased resistance to natural killer Cell cytotoxicity through resistance to cytolytic proteins.
- Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.
- A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced Cell death.
- Cytotoxic Cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.
- Hepatic natural killer Cells exclusively kill splenic/blood natural killer-resistant tumor Cells by the perforin/granzyme pathway.
- Cytotoxic Cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target Cells without plasma membrane pore formation.
- HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.
- Glomerulosclerosis in the sudden infant death Syndrome.
- Mouse granzyme K has pro-inflammatory potential.
- IntraCellular trafficking of perforin: to thwart a killer.
- Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins. Fluorescence perturbation and fluorescence resonan...
- Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific Cells.
- Activation of a cysteine protease in MCF-7 and T47D breast cancer Cells during beta-lapachone-mediated apoptosis.
- ExtraCellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors.
- Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perf...
- The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid Arthritis (RA).
- Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo.
- Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.
- BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.
- Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
- FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
- Pro-caspase-3 is a major physiologic target of caspase-8.
- An antimicrobial activity of cytolytic T Cells mediated by granulysin.
- Nuclear targeting of the serine protease granzyme A (fragmentin-1).
- Entry and trafficking of granzyme B in target Cells during granzyme B-perforin-mediated apoptosis.
- The CD8+ granzyme B+ T-Cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone Cells.
- Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast Cell tryptase.
- ExtraCellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo.
- Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases.
- Granule-mediated killing: pathways for granzyme B-initiated apoptosis.
- Granzyme B independently of perforin mediates noncytolytic intraCellular inactivation of vesicular stomatitis virus.
- Routine measurement of IgM, IgG, and IgA rheumatoid factors: high sensitivity, specificity, and predictive value for rheumatoid Arthritis.
- Human perforin: rapid enrichment by immobilized metal affinity chromatography (IMAC) for whole Cell cytotoxicity assays.
- New paradigm for lymphocyte granule-mediated cytotoxicity. Target Cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery...
- Granzyme B/perforin-mediated apoptosis of Jurkat Cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fra...
- Cytotoxic T-Cell-derived granzyme B activates the apoptotic protease ICE-LAP3.
- ExtraCellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin.
- ExtraCellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial Cell lines.
- The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.
- ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T Cell protease granzyme B.
- Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
- Rapid purification of cationic granule proteases: application to human granzymes.
- Human granzyme B is essential for DNA fragmentation of susceptible target Cells.
- Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein.
- Thrombin induces IL-6 production in fibroblasts and epithelial Cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin.
- A case of Guillain-Barré Syndrome with immunologic abnormalities.
- Human E-rosette-positive Cells which bind monomeric IgG mediate natural cytotoxicity.
- T gamma subset specificity of lymphocyte reactive factors in juvenile rheumatoid Arthritis and systemic lupus erythematosus sera.
- Flow cytometry and cytoadherence studies of sera from children with juvenile rheumatoid Arthritis and normal controls.
- Natural cytotoxicity in systemic lupus erythematosus: mechanisms of suppression by inhibitory serum factors.
- Natural killing and antibody-dependent Cellular cytotoxicity: characterization of effector Cells by E-rosetting and monoclonal antibodies.
- Interferon-alpha regulation of lymphocyte function in systemic lupus erythematosus.
- Abnormal interferon modulation of natural cytotoxicity in systemic lupus erythematosus. Relation to suppressive serum factors.
- Pregnancy, a temporary fetal graft of suppressor cells in autoimmune Disease?
- High anion gap acidosis during intravenous infusion of protein hydrolysate.
- Separation of natural and antibody-dependent cytotoxicity by differential reactivity of human mononuclear Cell Fc receptors with IgG.
- Enrichment of natural killer Cells by negative selection: comparison to Percoll gradient separation method.
- Enhancement of natural cytotoxicity by beta-endorphin.
- Characterization of E-rosette-positive Fc-receptor-bearing Cells by flow cytometry.
- Lymphocytotoxic antibodies in Guillain-Barré Syndrome.
- The effect of beta-endorphin on natural cytotoxicity and antibody dependent Cellular cytotoxicity.
- Salmonella typhimurium mitogen induces proliferation of human B lymphocytes.
- Natural killer Cells do not lyse resting or mitogen-stimulated B Cells.
- Induction of lymphokine activated killer Cells in serum-free medium.
- Phytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion.
- Antiphospholipid antibodies associated with retinal vascular Disease.
- Lysis of human T Cell leukemia virus infected T and B lymphoid Cells by interleukin 2-activated killer Cells.
- Modulation of the autologous mixed lymphocyte reaction by beta-endorphin.
- Deficient interleukin-2-activated killer Cell cytotoxicity in patients with systemic lupus erythematosus.
- Retinal vein thrombosis in a patient with pernicious anemia and anticardiolipin antibodies.
- The T Cell death knell: immune-mediated tumor death in renal Cell carcinoma.
- HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas.
- Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma Cells.
Schools
Loyola University Of ChicagoStritch School Of Medicine
Bernalillo County Medical Center
University Nm Med Center
Procedures Preformed
- Joint Drainage
- Myofascial Trigger Point Injection
- Steroid Injection
- Trigger Point Injection
- View All
Conditions Treated
- Arthritis
- Bursitis
- Calcium Pyrophosphate Dihydrate Deposition Disease (CPPD)
- Carpal Tunnel Syndrome
- View All
Doctors Specialties
- Rheumatology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Fellow (FACR)
Education
-
University of New Mexico -
Loyola University Chicago Stritch School of Medicine
Helpful Reviews
Similar Doctors
|
Dr. Suhair Abdel-Jalil, MD |
|
Dr. Aarti Malik, MD
 This Doctor is OpenDoctor Recommended.
|
|
Dr. Keith R. Sarpolis, MD
This Doctor is OpenDoctor Recommended.
|
|
Dr. Satyendra Humad, MD
This Doctor is OpenDoctor Recommended.
|
|
Dr. Sylvia Duby, MD
This Doctor is OpenDoctor Recommended.
|
|
Dr. Amanda K. Myers, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Manish H. Jain, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Tanmayee S. Bichile, MD |
|
|
Dr. James Embrescia, MD |