intensivist scottsdale osborn hospital
Pulmonology
Dr. Christopher J. Roberts, MD
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Christopher Roberts is an expert in the field of Pulmonology. He went to medical school at University of Colorado Denver School of Medicine. University of Colorado Denver School of Medicine is one of the top medical schools in the US. University of Colorado Denver School of Medicine is ranked 35 in research and 8 in primary care medicine Dr. Christopher J. Roberts is also a published doctor. He has 54 paper published. The most recent paper is: Acetate- and Citrate-Specific Ion Effects on Unfolding and Temperature-Dependent Aggregation Rates of Anti-Streptavidin IgG1.
Publications
- Weak protein interactions and pH- and temperature-dependent aggregation of human Fc1.
- Aggregation of poly(acrylic acid)-containing elastin-mimetic copolymers.
- Role of anisotropic interactions for proteins and patchy nanoparticles.
- Protein aggregation and its impact on product quality.
- Therapeutic protein aggregation: mechanisms, design, and control.
- Protein-Protein Interactions in Dilute to Concentrated Solutions: α-Chymotrypsinogen in Acidic Conditions.
- Conformational stability as a design target to control protein aggregation.
- Competing aggregation pathways for monoclonal antibodies.
- Endocannabinoid signaling in hypothalamic-pituitary-adrenocortical axis recovery following stress: Effects of indirect agonists and comparison of male and female mice.
- Coarse-grained model for colloidal protein interactions, b22, and protein cluster formation.
- Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation.
- Aggregates of α-chymotrypsinogen anneal to access more stable states.
- Protein misfolding and aggregation research: Some thoughts on improving quality and utility.
- Effects of Temperature and Osmolytes on Competing Degradation Routes for an IgG1 Antibody.
- Non-Arrhenius Protein Aggregation.
- Aggregation of anti-streptavidin immunoglobulin gamma-1 involves Fab unfolding and competing growth pathways mediated by pH and salt concentration.
- Coarse-grained modeling of protein second osmotic virial coefficients: sterics and short-ranged attractions.
- Aggregation and pH-temperature phase behavior for aggregates of an IgG2 antibody.
- Recruitment of Prefrontal Cortical Endocannabinoid Signaling by Glucocorticoids Contributes to Termination of the Stress Response.
- Reexamining protein-protein and protein-solvent interactions from Kirkwood-Buff analysis of light scattering in multi-component solutions.
- Conformational and Aggregation Properties of a PEGylated Alanine-Rich Polypeptide.
- Predicting accelerated aggregation rates for monoclonal antibody formulations, and challenges for low-temperature predictions.
- Nonnative aggregation of an IgG1 antibody in acidic conditions, part 2: Nucleation and growth kinetics with competing growth mechanisms.
- Nonnative aggregation of an IgG1 antibody in acidic conditions: Part 1. Unfolding, colloidal interactions, and formation of high-molecular-weight aggregates.
- Predicting solution aggregation rates for therapeutic proteins: Approaches and challenges.
- Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and i...
- Molecular level insights into thermally induced α-chymotrypsinogen A amyloid aggregation mechanism and semiflexible protofibril morphology.
- Comparative effects of pH and ionic strength on protein-protein interactions, unfolding, and aggregation for IgG1 antibodies.
- Deficiency in endocannabinoid signaling in the nucleus accumbens induced by Chronic unpredictable stress.
- Multi-variate approach to global protein aggregation behavior and kinetics: effects of pH, NaCl, and temperature for alpha-chymotrypsinogen A.
- Characterization of high-molecular-weight nonnative aggregates and aggregation kinetics by size exclusion chromatography with inline multi-angle laser light scattering.
- Structure and thermodynamics of colloidal protein cluster formation: comparison of square-well and simple dipolar models.
- Lumry-Eyring nucleated-polymerization model of protein aggregation kinetics. 2. Competing growth via condensation and chain polymerization.
- Principles, approaches, and challenges for predicting protein aggregation rates and shelf life.
- Modulation of self-association and subsequent fibril formation in an alanine-rich helical polypeptide.
- Notch-deficient skin induces a lethal Systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.
- Nucleation, growth, and activation energies for seeded and unseeded aggregation of alpha-chymotrypsinogen A.
- Solvation in mixed aqueous solvents from a thermodynamic cycle approach.
- Nonnative protein polymers: structure, morphology, and relation to nucleation and growth.
- Non-native protein aggregation kinetics.
- A quasichemical approach for protein-cluster free energies in dilute solution.
- Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia.
- A Lumry-Eyring nucleated polymerization model of protein aggregation kinetics: 1. Aggregation with pre-equilibrated unfolding.
- Non-native aggregation of alpha-chymotrypsinogen occurs through nucleation and growth with competing nucleus sizes and negative activation energies.
- Molecular solvation in water-methanol and water-sorbitol mixtures: the roles of preferential hydration, hydrophobicity, and the equation of state.
- Developing gene expression signatures of pathway deregulation in tumors.
- Exploration of essential gene functions via titratable promoter alleles.
- Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.
- Irreversible aggregation of recombinant bovine granulocyte-colony stimulating factor (bG-CSF) and implications for predicting protein shelf life.
- Development of a DNA microarray for toxicology based on hepatotoxin-regulated sequences.
- Stabilization of pharmaceuticals to oxidative degradation.
- Clinical and microbiological aspects of biofilm-associated surgical site infections.
- Acetate- and Citrate-Specific Ion Effects on Unfolding and Temperature-Dependent Aggregation Rates of Anti-Streptavidin IgG1.
Schools
UNIVERSITY OF COLORADO AT DENVER
Maricopa Med Center
Procedures Preformed
- Bronchoscopy
- Thoracentesis
- Ventilation Management
Conditions Treated
- Acidosis
- Alkalosis
- Asthma
- Atelectasis
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Doctors Specialties
- Critical Care Medicine
- Pulmonology
Accepted Insurances
Education
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Maricopa Medical Center -
University of Colorado Denver School of Medicine
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