Professor and Chair, Dept of Laboratory Medicine, UCSF School of Medicine

Internal Medicine

Doctor Clifford A. Lowell, MD works in the field of Internal Medicine. He researched medicine at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is one of the top medical schools in the US. Johns Hopkins University School of Medicine is ranked 3 in research and 29 in primary care medicine Doctor Clifford A. Lowell, MD is a published doctor. He has 101 papers published. The most current publication "Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells."

Publications

---

• Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells.
• The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.
• Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
• Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.
• Store-operated calcium signaling in neutrophils.
• Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.
• Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice.
• Prospective Study on the Clinical Course and Outcomes in Transfusion-Related Acute Lung Injury.
• The STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.
• Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.
• B Cell-Specific Loss of Lyn Kinase Leads to Autoimmunity.
• A critical role for Lyn kinase in strengthening endothelial integrity and barrier function.
• The Multifaceted Functions of Neutrophils.
• Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.
• CXCL13 plus interleukin-10 are highly specific for the diagnosis of CNS lymphoma.
• Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice.
• Tracing Conidial Fate and Measuring Host Cell Antifungal Activity Using a Reporter of Microbial Viability in the Lung.
• Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma.
• Dectin-1-triggered Recruitment of Light Chain 3 Protein to Phagosomes Facilitates Major Histocompatibility Complex Class II Presentation of Fungal-derived Antigens.
• Distinct and overlapping functional roles of Src family kinases in mouse platelets.
• Fresh and Stored Red Blood Cell Transfusion Equivalently Induce Subclinical Pulmonary Gas Exchange Deficit in Normal Humans.
• B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K.
• Overview: studying integrins in vivo.
• Transfusion related acute lung injury: incidence and risk factors.
• Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa.
• Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.
• Deletion of syk in neutrophils prevents immune complex arthritis.
• B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.
• The Process of Macrophage Migration Promotes Matrix Metalloproteinase-Independent Invasion by Tumor Cells.
• Differential transformation capacity of Src family kinases during the initiation of prostate cancer.
• Neutrophils give us a shock.
• Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells.
• Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk.
• IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
• Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection.
• Interferon-{gamma} Production by Neutrophils during Bacterial Pneumonia in Mice.
• The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
• Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.
• An important role of the SRC family kinase Lyn in stimulating platelet granule secretion.
• Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis.
• Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
• Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.
• The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.
• Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.
• Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells.
• The ins and outs of leukocyte integrin signaling.
• Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.
• Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.
• Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.
• PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.
• Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
• Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.
• The diverse functions of Src family kinases in macrophages.
• The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.
• Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.
• Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to R...
• The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine.
• Src family kinases mediate neutrophil adhesion to adherent platelets.
• The expanding role for ITAM-based signaling pathways in immune cells.
• Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
• Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.
• Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.
• Lyn kinase promotes erythroblast expansion and late-stage development.
• Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.
• Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.
• Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr.
• Rewiring phagocytic signal transduction.
• G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.
• Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells.
• Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.
• Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
• The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation.
• Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.
• Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.
• IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.
• The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.
• The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
• The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.
• Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors.
• Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival.
• Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin ...
• Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.
• Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.
• The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.
• The Src kinase Lyn is a negative regulator of mast cell proliferation.
• SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils.
• Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.
• Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice.
• Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading.
• G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells.
• Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.
• Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.
• Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
• Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation.
• Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
• Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with g...
• Syk is required for integrin signaling in neutrophils.
• LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.
• Src and Syk kinases: key regulators of phagocytic cell activation.
• c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.

Schools

---

• Johns Hopkins University School of Medicine

• Johns Hopkins Hospital

• Ucsf Med Center

Doctors Specialties

---

• Internal Medicine

Accepted Insurances

---

Education

---

• Johns Hopkins University
• Johns Hopkins University School of Medicine

Hospital

---

• UCSF Medical Center

Helpful Reviews

---

Give Anonymous Review

Similar Doctors

---

	Dr. Erica M. Metz, MD This Doctor is OpenDoctor Recommended.
	Dr. Harlan B. Watkins, MD This Doctor is OpenDoctor Recommended.
	Dr. Fred E. Cohen, MD
	Dr. Catherine M. Ogara, MD This Doctor is OpenDoctor Recommended.
	Dr. Romana Usman, MD This Doctor is OpenDoctor Recommended.
	Dr. Li Yu, MD This Doctor is OpenDoctor Recommended.
	Dr. Edward A. Chow, MD This Doctor is OpenDoctor Recommended.
	Dr. Jessica A. Lickiss, DPM
	Dr. Wei Rao, MD
	Dr. Katherine E. Schmidt, MD This Doctor is OpenDoctor Recommended.
	Dr. Brian D. Muegge, MD
	Dr. Aliza S. Norwood, MD This Doctor is OpenDoctor Recommended.

---

Doctor Directory | TOS | twitter | FB | Angel | blog