Chief, Division of Gastroenterology, Hepatology and Nutrition
Gastroenterology
Dr. Curt H. Hagedorn, MD
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Curt Hagedorn practices Gastroenterology. He went to medical school at Washington University School of Medicine in St. Louis. Doctor Curt H. Hagedorn, MD is also a published physician. He has 68 paper published. The most recent paper is: Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli.
Publications
- Direct visualization of HCV-infected Huh7.5 cells with a high-titre infectious chimeric JFH1-EGFP reporter virus in 3D matrigel cell cultures.
- The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.
- HCV Infection Selectively Impairs Type I but Not Type III IFN Signaling.
- Genome-wide Transcriptome Analysis Identifies Novel Gene Signatures Implicated in Human Chronic Liver Disease.
- IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease.
- A Cell Culture Adapted HCV JFH1 Variant That Increases Viral Titers and Permits the Production of High Titer Infectious Chimeric Reporter Viruses.
- Mechanism of thrombocytopenia in chronic hepatitis C as evaluated by the immature platelet fraction.
- RNA-sequencing analysis of 5' capped RNAs identifies many new differentially expressed genes in acute hepatitis C virus infection.
- The pharmacokinetics of peginterferon alfa-2a and ribavirin in African American, Hispanic and Caucasian patients with chronic hepatitis C.
- Phenotypic and genotypic differences between a child with vertically acquired severe hepatitis C liver Disease and his mother.
- ENCODE tiling array analysis identifies differentially expressed annotated and novel 5' capped RNAs in hepatitis C infected liver.
- Measuring antiviral activity of benzimidazole molecules that alter IRES RNA structure with an infectious hepatitis C virus chimera expressing Renilla luciferase.
- Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors.
- Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial.
- Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.
- Laminar shear stress and 3' polyadenylation of eNOS mRNA.
- Hepatitis C virus genotype distribution in China: predominance of closely related subtype 1b isolates and existence of new genotype 6 variants.
- DNA microarrays and data mining to study hepatic fibrosis.
- Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs.
- Analysis of mutant NS5B proteins encoded by isolates from chimpanzees chronically infected following clonal HCV RNA inoculation.
- NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis.
- Purifying mRNAs with a high-affinity eIF4E mutant identifies the short 3' poly(A) end phenotype.
- Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype.
- Temporal trends over ten years in formal inpatient gastroenterology consultations at an inner city hospital.
- Immortal activated human hepatic stellate cells generated by ectopic telomerase expression.
- RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers.
- Determining sources of fecal pollution in a rural Virginia watershed with antibiotic resistance patterns in fecal streptococci.
- [Hodgkin''s Disease: effect of spenectomy on the immune status (author''s transl)].
- Demonstration of a NADPH-linked delta 1-pyrroline-5-carboxylate-proline shuttle in a cell-free rat liver System.
- Proline metabolism in N2-fixing root nodules: energy transfer and regulation of purine synthesis.
- Rhizobacteria of cotton and their repression of seedling Disease pathogens.
- Selective inhibition of proteins synthesized from different mRNA species in reticulocyte lysates containing L-pyrroline-5-carboxylic acid.
- Phosphorylation of the p220 subunit of eIF-4F by cAMP dependent protein kinase and protein kinase C in vitro.
- Use of a monoclonal antibody (APE-1) directed against the conserved GTPEYLAPE motif present in protein kinases as an affinity purification reagent.
- Transfer of 1-pyrroline-5-carboxylate as oxidizing potential from hepatocytes to erythrocytes.
- A liquid, colorimetric presence-absence coliphage detection method.
- Improved method for coliphage detection based on beta-galactosidase induction.
- Microbial source tracking in a rural watershed dominated by cattle.
- Identification of a protein kinase activity in rabbit reticulocytes that phosphorylates the mRNA cap binding protein.
- Casein kinase I phosphorylates the 25-kDa mRNA cap-binding protein.
- Yeast casein kinase I homologues: an essential gene pair.
- Development and characterization of polyclonal antibodies against a conserved sequence in the catalytic domain of protein kinases.
- Protein kinase C phosphorylates both serine and threonine residues of the mRNA cap binding protein eIF-4E.
- Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits.
- Lipopolysaccharide stimulates phosphorylation of eukaryotic initiation factor-4F in macrophages and tumor necrosis factor participates in this event.
- Salmonella typhimurium translocates flagellin across Intestinal epithelia, inducing a proinflammatory response.
- Reduced FMRP and increased FMR1 transcription is proportionally associated with CGG repeat number in intermediate-length and premutation carriers.
- Structural requirements for the specific recognition of an m7G mRNA cap.
- Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.
- Epidermal growth factor or okadaic acid stimulates phosphorylation of eukaryotic initiation factor 4F.
- Modulation of eucaryotic initiation factor-4E binding to 5'-capped oligoribonucleotides by modified anti-sense oligonucleotides.
- Induction of eIF-4E phosphorylation by the addition of L-pyrroline-5-carboxylic acid to rabbit reticulocyte lysate.
- Modifications of eukaryotic initiation factor 4F (eIF4F) in adult cardiocytes by adenoviral gene transfer: differential effects on eIF4F activity and total protein syn...
- Erythropoietin stimulates phosphorylation of eIF-4E and identification of a 37-kD phosphoprotein that binds mRNA caps in erythroblasts.
- Platelet-derived growth factor stimulates phosphorylation of the 25 kDa mRNA cap binding protein (eIF-4E) in human lung fibroblasts.
- Phosphoprotein phosphatase 2A dephosphorylates eIF-4E and does not alter binding to the mRNA cap.
- Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli.
- Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase).
- Expression of functional eIF-4Ehuman: purification, detailed characterization, and its use in isolating eIF-4E binding proteins.
- Identification of the cap binding domain of human recombinant eukaryotic protein synthesis initiation factor 4E using a photoaffinity analogue.
- A mutant of eukaryotic protein synthesis initiation factor eIF4E(K119A) has an increased binding affinity for both m7G cap analogues and eIF4G peptides.
- Prospective multicenter study of eligibility for antiviral therapy among 4,084 U.S. veterans with chronic hepatitis C virus infection.
- Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells.
- Mutations in the S4-H2 loop of eIF4E which increase the affinity for m7GTP.
- A refined long RT-PCR technique to amplify complete viral RNA genome sequences from clinical samples: application to a novel hepatitis C virus variant of genotype 6.
- Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis.
- Hepatitis C virus complete genome sequences identified from China representing subtypes 6k and 6n and a novel, as yet unassigned subtype within genotype 6.
Schools
Washington Center School of Medicine
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
Conditions Treated
- Abdominal Pain
- Anemia
- Barrett's Esophagus
- Benign Neoplasm of the Digestive System
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Doctors Specialties
- Gastroenterology
- Transplant Hepatology
Accepted Insurances
Education
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Washington University -
National Institutes of Health Clinical Center -
Vanderbilt University -
Washington University School of Medicine in St. Louis
Hospital
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University of Utah Health Care - Hospital and Clinics
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