Professor, Pediatrics, UCSF School of Medicine
Neonat/Perinatology
Dr. David H. Rowitch, MD
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Dr. David H. Rowitch practices Neonat/Perinatology. He studied medicine at David Geffen School of Medicine at UCLA. David Geffen School of Medicine at UCLA is a one of the best medicals schools. David Geffen School of Medicine at UCLA has a rank of 13 in research and a 7 in primary care He received 1 awards: "Investigator". David Rowitch is also published. He has 100 publications published. The lastest publication: "Neonatal herpes simplex virus infection presenting as fulminant liver failure.'
Publications
- Disease specific therapies in leukodystrophies and leukoencephalopathies.
- Astrocyte Development and Heterogeneity.
- Postnatal growth of the human pons: A morphometric and immunohistochemical analysis.
- Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis.
- An amino terminal phosphorylation motif regulates intranuclear compartmentalization of olig2 in neural progenitor cells.
- Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.
- Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.
- Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.
- Cerebellar cortical lamination and foliation require cyclin A2.
- Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions.
- A Dramatic Increase of C1q Protein in the CNS during Normal Aging.
- Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease.
- Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
- STAT3-mediated astrogliosis protects myelin development in neonatal brain injury.
- Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord.
- Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair.
- Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
- Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.
- Evidence that nuclear factor IA inhibits repair after white matter injury.
- Olig1 function is required for remyelination potential of transplanted neural progenitor cells in a model of viral-induced demyelination.
- Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination.
- Targeted Therapy for BRAFV600E Malignant Astrocytoma.
- A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury.
- Corridors of migrating neurons in the human brain and their decline during infancy.
- Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells.
- Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.
- Role of academic medical centers in cell-based therapeutic clinical trials.
- Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma.
- Phosphorylation state of Olig2 regulates proliferation of neural progenitors.
- The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.
- NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants.
- Myelin regeneration: a recapitulation of development?
- Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain.
- Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination.
- NIH Consensus Development Conference: Inhaled Nitric Oxide Therapy for Premature Infants.
- Overcoming remyelination failure in multiple sclerosis and other myelin disorders.
- Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma.
- CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.
- Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.
- Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination.
- A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.
- Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
- Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.
- Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.
- Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism.
- Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.
- Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
- Glioma stem cells: a midterm exam.
- Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.
- Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain.
- Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.
- Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.
- Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis.
- N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.
- Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord.
- Olig gene function in CNS development and disease.
- Development of NG2 neural progenitor cells requires Olig gene function.
- Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube.
- Histology-based expression profiling yields novel prognostic markers in human glioblastoma.
- The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.
- Mouse brain organization revealed through direct genome-scale TF expression analysis.
- bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
- Molecular diversity of astrocytes with implications for neurological disorders.
- The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.
- Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.
- Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers.
- Synchronization of goat fibroblast cells at quiescent stage and determination of their transition from G0 to G1 by detection of cyclin D1 mRNA.
- Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice.
- Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.
- Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest.
- Development of mice expressing a single D-type cyclin.
- Medulloblastoma: a problem of developmental biology.
- Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach.
- Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection.
- Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
- Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives.
- Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.
- Expression and function of Nkx6.3 in vertebrate hindbrain.
- Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia.
- Conserved role of intragenic DNA methylation in regulating alternative promoters.
- Myelin restoration: progress and prospects for human cell replacement therapies.
- Developmental genetics of vertebrate glial-cell specification.
- Towards improved animal models of neonatal white matter injury associated with cerebral palsy.
- Effect of coat protein mutations in bacteriophage fd studied by sedimentation analysis.
- Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase.
- Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex.
- Neonatal herpes simplex virus infection presenting as fulminant liver failure.
- Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit.
- Olig2 expression, GFAP, p53 and 1p loss analysis contribute to glioma subclassification.
- Nuclear Localization of the Mitochondrial Factor HIGD1A during Metabolic Stress.
- A FOXO-Pak1 transcriptional pathway controls neuronal polarity.
- A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.
- Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair.
- OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms.
- A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.
- The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes.
- Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination.
- A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.
- Origin of oligodendrocytes in the subventricular zone of the adult brain.
Schools
University of California At Los Angeles
Children39s Hospital
Doctors Specialties
- Neonatal Medicine
- Neonat/Perinatology
Accepted Insurances
- Blue Card PPO
- Blue Cross Blue Shield of California PPO
- Brown & Toland Physicians
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Commercial Insurance Company
- First Health (Coventry Health Care) PPO
- Covered California - Bronze PPO
- Health Net PPO
- Individual and Family PPO
- Medicare MCR
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Investigator
Education
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Boston Children's Hospital -
David Geffen School of Medicine at UCLA
Hospital
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San Francisco General Hospital and Trauma Center -
UCSF Medical Center
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