Physician

Pediatrics

David W. Banner practices Pediatrics. He graduated from Mount Sinai School of Medicine. He received awards:"Patient-Centered Medical Home Recognition Program" and "Physician Practice Connections Recognition Program". David Banner is a published doctor. He has 63 papers published. The most current publication "Coagulation factor VII Gln100 --> Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor bin..."

Publications

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• Molecular Recognition at the Active Site of Factor Xa: Cation-?? Interactions, Stacking on Planar Peptide Surfaces, and Replacement of Structural Water.
• Halogen Bonding at the Active Sites of Human Cathepsin???L and MEK1 Kinase: Efficient Interactions in Different Environments.
• The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment.
• A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo.
• Design and synthesis of potent and highly selective thrombin inhibitors.
• Inhibitor binding to thrombin: x-ray crystallographic studies.
• Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.
• Control of ColE1 replication: low affinity specific binding of Rop (Rom) to RNAI and RNAII.
• Genetic and structural analysis of the ColE1 Rop (Rom) protein.
• The crystal structure of pseudoazurin from Alcaligenes faecalis S-6 determined at 2.9 A resolution.
• Structure of the ColE1 rop protein at 1.7 A resolution.
• Activation of blood coagulation factor VIIa with cleaved tissue factor extracellular domain and crystallization of the active complex.
• Crystallization and preliminary crystallographic analysis of a TNF-beta-55 kDa TNF receptor complex.
• Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
• The crystal structure of EcoRV endonuclease and of its complexes with cognate and non-cognate DNA fragments.
• The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor.
• Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of...
• Inherited factor VII deficiency: molecular genetics and pathophysiology.
• The factor VIIa/tissue factor complex.
• Coagulation factor VII Gln100 --> Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor bin...
• Combinatorial docking and combinatorial chemistry: design of potent non-peptide thrombin inhibitors.
• Enzymology. Not just an active site.
• Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.
• 2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide de...
• Structure-based approaches in modern drug discovery research.
• Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.
• A 2.0-A structure of the blue copper protein (cupredoxin) from Alcaligenes faecalis S-6.
• [A new generation of anticoagulants: design, synthesis and pharmacologic profile of thrombin inhibtors].
• Cortical spreading depression transiently activates MAP kinases.
• Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity.
• Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors.
• Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups into the p...
• Cation-pi interactions at the active site of factor Xa: dramatic enhancement upon stepwise N-alkylation of ammonium ions.
• Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.
• Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-...
• Systematic investigation of halogen bonding in protein-ligand interactions.
• Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors.
• Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand.
• Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
• Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrop...
• Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions.
• Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors.
• A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.
• A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermole...
• Fluorine in medicinal chemistry.
• Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain.
• In vivo ribavirin activity against severe pandemic H1N1 Influenza A/Mexico/4108/2009.
• Host adaptive immunity deficiency in severe pandemic influenza.
• Fragment-based screening using surface plasmon resonance technology.
• Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza.
• Modeling host responses in ferrets during A/California/07/2009 influenza infection.
• Molecular characterization of in vivo adjuvant activity in ferrets vaccinated against influenza virus.
• The diaphanous inhibitory domain/diaphanous autoregulatory domain interaction is able to mediate heterodimerization between mDia1 and mDia2.
• Cloning, expression and characterization of ferret CXCL10.
• Cloning, expression and immunoassay detection of ferret IFN-gamma.
• Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases.
• Comparative analyses of pandemic H1N1 and seasonal H1N1, H3N2, and influenza B infections depict distinct clinical pictures in ferrets.
• Seasonal H1N1 Influenza Virus Infection Induces Cross-Protective Pandemic H1N1 Virus Immunity through a CD8-Independent, B Cell-Dependent Mechanism.
• Influenza-associated encephalopathy with elevated antibody titers to pandemic (H1N1) 2009 influenza.
• Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severity.
• Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza.
• Molecular and structural advances in tissue factor-dependent coagulation.

Schools

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• Albert Einstein College of Medicine of Yeshiva University

• Mt Sinai School Of Med

Doctors Specialties

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• Pediatrics

Accepted Insurances

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Awards

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• Patient-Centered Medical Home Recognition Program
• Physician Practice Connections Recognition Program

Education

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• Mount Sinai School of Medicine
• Albert Einstein College of Medicine of Yeshiva University

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