Physician
Gastroenterology
Dr. David W. Crabb, MD
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David Crabb is an expert in the field of Gastroenterology. He attended Indiana University School of Medicine. Indiana University School of Medicine is ranked 45/47 in Research/PrimaryCare. He received awards:"Elected Member". Dr. David W. Crabb is a published doctor and has 100 publications published. The lastest was: 'Studies on the enzymology of aldehyde dehydrogenase-2 in genetically modified HeLa cells.' Dr. David W. Crabb is registered with Medicare.
Publications
- Novel serum biomarkers for detection of excessive alcohol use.
- Increasing serum pre-adipocyte factor-1 (Pref-1) correlates with decreased body fat, increased free fatty acids, and level of recent alcohol consumption in excessive a...
- Activation of carbohydrate Response element-binding protein by ethanol.
- Chronic Free-Choice Drinking in Crossed High Alcohol Preferring Mice Leads to Sustained Blood Ethanol Levels and Metabolic Tolerance Without Evidence of Liver Damage.
- Alcohol Exposure Rate Control Through Physiologically Based Pharmacokinetic Modeling.
- Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice.
- Activated AMPK Inhibits PPAR{alpha} and PPAR{gamma} Transcriptional Activity in Hepatoma Cells.
- Ethanol Impairs Differentiation of Human Adipocyte Stromal Cells in Culture.
- Relationship among alcohol intake, body fat, and physical activity: a population-based study.
- Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels.
- Relationship between alcohol drinking and aspartate aminotransferase:alanine aminotransferase (AST:ALT) ratio, mean corpuscular volume (MCV), gamma-glutamyl transpepti...
- Serum Proteomic Profiles In Subjects with Heavy Alcohol Abuse.
- Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.
- Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation.
- Alcohol and lipid metabolism.
- Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells.
- Global effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism.
- Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice.
- The role of AMP-activated protein kinase in the action of ethanol in the liver.
- Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatoHepatitis.
- Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha.
- Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins.
- Recent advances in alcoholic liver Disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
- Alcohol deranges hepatic lipid metabolism via altered transcriptional regulation.
- Does leptin play a role in the pathogenesis of human nonalcoholic steatoHepatitis?
- Metabolic and anthropometric evaluation of insulin resistance in nondiabetic patients with nonalcoholic steatoHepatitis.
- Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-...
- Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatoHepatitis.
- Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP).
- Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
- Metabolism.
- Eta'' photoproduction on the proton for photon energies from 1.527 to 2.227 GeV.
- 32-year-old man with nausea, vomiting and metastatic adenocarcinoma.
- Photoproduction of the rho(0) meson on the proton at large momentum transfer.
- First measurement of the double spin asymmetry in (-->)e(-->)p-->e(prime)pi(+)n in the resonance region.
- Photoproduction of the omega meson on the proton at large momentum transfer.
- Eta photoproduction on the proton for photon energies from 0.75 to 1.95 GeV.
- Measurement of ep-->e'' ppi+ pi- and baryon resonance analysis.
- Onset of asymptotic scaling in deuteron photodisintegration.
- Measurement of the proton spin structure function g1(x,Q2) for Q2 from 0.15 to 1.6 GeV2 with CLAS.
- Two-nucleon momentum distributions measured in 3He(e,e''pp)n.
- Measurement of the N-->Delta(+)(1232) transition at high-momentum transfer by pi(0) electroproduction.
- Precise measurement of the neutron magnetic form factor G(M)n in the few-GeV2 region.
- Search for the photoexcitation of exotic mesons in the pi+pi+pi- system.
- Measurement of direct f0(980) photoproduction on the proton.
- Measurement of deeply virtual compton scattering with a polarized-proton target.
- Measurement of single- and double-spin asymmetries in deep inelastic pion electroproduction with a longitudinally polarized target.
- Search for the Theta+ Pentaquark in the gammad--> DeltanK+ reaction measured with the CLAS spectrometer.
- Search for the Theta+ pentaquark in the reaction gammad --> pK-K+n.
- Experimental study of exclusive 2H(e,e''p)n reaction mechanisms at high Q2.
- Measurement of deeply virtual compton scattering beam-spin asymmetries.
- Bayesian analysis of pentaquark signals from CLAS data.
- Search for medium modifications of the rho meson.
- Observation of an exotic S = +1 baryon in exclusive photoproduction from the deuteron.
- First measurement of transferred polarization in the exclusive ep-->e''K+Lambda--> reaction.
- Oral medications for upper gastroIntestinal endoscopy using a small diameter endoscope.
- Alcohol metabolism in human cells causes DNA damage and activates the Fanconi Anemia-breast cancer susceptibility (FA-BRCA) DNA damage response network.
- 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism.
- The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and Disease.
- The retinoid X receptor Response element in the human aldehyde dehydrogenase 2 promoter is antagonized by the chicken ovalbumin upstream promoter family of orphan rece...
- The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis.
- Identification of the 37-kd rat liver protein that forms an acetaldehyde adduct in vivo as delta 4-3-ketosteroid 5 beta-reductase.
- Studies on the enzymology of aldehyde dehydrogenase-2 in genetically modified HeLa cells.
- Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice.
- Use of cultured cells in assessing ethanol toxicity and ethanol-related metabolism.
- A polymorphism in the rat liver mitochondrial ALDH2 gene is associated with alcohol drinking behavior.
- Studies on the dominant negative effect of the ALDH2*2 allele.
- High-level expression of RXRalpha and the presence of endogenous ligands contribute to expression of a peroxisome proliferator-activated receptor-responsive gene in he...
- Activity of the human aldehyde dehydrogenase 2 promoter is influenced by the balance between activation by hepatocyte nuclear factor 4 and repression by perosixome pro...
- High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells.
- Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stella...
- Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors.
- Identification of a retinoid receptor Response element in the human aldehyde dehydrogenase-2 promoter.
- Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration.
- A proteomic workflow for discovery of serum carrier protein-bound biomarker candidates of alcohol abuse using LC-MS/MS.
- Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population.
- Alcoholic myopathy and acetaldehyde.
- Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes.
- Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells.
- Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology.
- Reproducibility of oligonucleotide arrays using small samples.
- Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcohol-preferring and -nonpreferring rats.
- The role of nuclear factor NF-Y/CP1 in the transcriptional regulation of the human aldehyde dehydrogenase 2-encoding gene.
- Gene regulation of alcohol metabolizing enzymes.
- Dexamethasone represses phorbol ester-, forskolin-, and calcium-stimulated expression of a preproenkephalin A promoter-chloramphenicol acetyltransferase gene via a rec...
- The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant...
- Structural and mechanistic similarities of 6-phosphogluconate and 3-hydroxyisobutyrate dehydrogenases reveal a new enzyme family, the 3-hydroxyacid dehydrogenases.
- Hormonal and chemical influences on the expression of class 2 aldehyde dehydrogenases in rat H4IIEC3 and human HuH7 hepatoma cells.
- Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues.
- Catabolism of isobutyrate by colonocytes.
- Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism.
- Modulation of hepatic and renal alcohol dehydrogenase activity and mRNA by steroid hormones in vivo.
- Evolutionary relationships of branched chain and nonspecific alcohol and aldehyde dehydrogenases.
- Effects of thyroxine on the expression of alcohol dehydrogenase in rat liver and kidney.
- Effects of ethanol on urinary acidification and on gluconeogenesis by isolated renal tubules.
- Alcohol sensitivity, alcohol metabolism, risk of alcoholism, and the role of alcohol and aldehyde dehydrogenase genotypes.
- Molecular cloning of the branched-chain alpha-keto acid dehydrogenase kinase and the CoA-dependent methylmalonate semialdehyde dehydrogenase.
- Alcohol dehydrogenase polymorphisms and predisposition to alcoholic Cirrhosis.
- Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases.
Schools
Indiana University School of Medicine
In University Med Center
Procedures Preformed
- Endoscopy (Esophagus, Stomach, Small Intestine)
- Liver Biopsy
Conditions Treated
- Abdominal Pain
- Anemia
- Cholecystitis and Gallstones
- Cirrhosis
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Doctors Specialties
- Gastroenterology
Accepted Insurances
- Pathway X Bronze Direct CACA IN HIX
- Anthem Blue Cross Blue Shield HMO
- Anthem Blue Cross Blue Shield PPO
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Cofinity PPO
- Commercial Insurance Company
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Sagamore Plus
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Elected Member
Education
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Indiana University School of Medicine
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1649234600 |
| Last Name Of The Provider | CRABB |
| First Name Of The Provider | DAVID |
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