William Ellery Channing Professor of Medicine, Channing Laboratory
Internal Medicine
Dr. Dennis L. Kasper, MD
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Dr. Dennis L. Kasper works in the field of Internal Medicine. He researched medicine at NYU School of Medicine. He has 1 awards "Elected Member". Dr. Dennis L. Kasper is a published MD. He has 101 papers published. The most current publication "Safety and immunogenicity of capsular polysaccharide-tetanus toxoid conjugate vaccines for group B streptococcal types Ia and Ib."
Publications
- In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria.
- Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells.
- A commensal bacterial product elicits and modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammation.
- Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms.
- Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells.
- Interactions between the intestinal microbiota and innate lymphoid cells.
- A maternal vaccine against group B Streptococcus: Past, present, and future.
- The atypical lipopolysaccharide ofFrancisella.
- Relevance of Commensal Microbiota in the Treatment and Prevention of Inflammatory Bowel Disease.
- Resident commensals shaping immunity.
- Traffic control at the "Gut-GALT crossroads"
- Kdo Hydrolase Is Required for Francisella tularensis Virulence and Evasion of TLR2-Mediated Innate Immunity.
- Isolation of carbohydrate-specific CD4(+) T cell clones from mice after stimulation by two model glycoconjugate vaccines.
- Gut immune maturation depends on colonization with a host-specific microbiota.
- Microbial exposure during early life has persistent effects on natural killer T cell function.
- Genetic Modification of the O-Polysaccharide of Francisella tularensis Results in an Avirulent Live Attenuated Vaccine.
- Bacteroides fragilis-Stimulated Interleukin-10 Contains Expanding Disease.
- Regulation of T cells by gut commensal microbiota.
- Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine.
- Systemic Toll-like receptor ligands modify B-cell responses in human inflammatory bowel disease.
- A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design.
- 3-Deoxy-D-manno-octulosonic acid (Kdo) hydrolase identified in Francisella tularensis, Helicobacter pylori, and Legionella pneumophila.
- Orientations of the Bacteroides fragilis capsular polysaccharide biosynthesis locus promoters during symbiosis and infection.
- Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.
- Characterization of the O-antigen polymerase (Wzy) of Francisella tularensis.
- How bacterial carbohydrates influence the adaptive immune system.
- Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma/delta T cells.
- Beneficial effects of Bacteroides fragilis polysaccharides on the immune system.
- Novel tools for modulating immune responses in the host-polysaccharides from the capsule of commensal bacteria.
- Small molecule control of virulence gene expression in Francisella tularensis.
- Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination.
- TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
- Symbiotic commensal bacteria direct maturation of the host immune system.
- IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection.
- Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching.
- Microbial carbohydrate depolymerization by antigen-presenting cells: deamination prior to presentation by the MHCII pathway.
- Regulation of surface architecture by symbiotic bacteria mediates host colonization.
- Group A streptococcus epidemiology and vaccine implications.
- A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.
- A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2.
- Bacterial glycans: key mediators of diverse host immune responses.
- A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
- Modulation of surgical fibrosis by microbial zwitterionic polysaccharides.
- Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome".
- Anchors away: contribution of a glycolipid anchor to bacterial invasion of host cells.
- Case records of the Massachusetts General Hospital. Case 25-2005. A 40-year-old man with prolonged fever and weight loss.
- An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.
- Identification of a universal Group B streptococcus vaccine by multiple genome screen.
- Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
- Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation.
- Regulation of virulence by a two-component system in group B streptococcus.
- Commentary: Bartlett JG, Onderdonk AB, Cisneros RL, Kasper DL. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters. J Infect Dis...
- Polysaccharide processing and presentation by the MHCII pathway.
- Immune response of healthy women to 2 different group B streptococcal type V capsular polysaccharide-protein conjugate vaccines.
- Zwitterionic polysaccharides stimulate T cells with no preferential V beta usage and promote anergy, resulting in protection against experimental abscess formation.
- Safety and immunogenicity of a bivalent group B streptococcal conjugate vaccine for serotypes II and III.
- CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism.
- Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice.
- A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides.
- Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions.
- Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent...
- Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae.
- Conjugate vaccines against group B Streptococcus types IV and VII.
- CD4+ T cells regulate surgical and postinfectious adhesion formation.
- Induction of cross-reactive antibodies by immunization of healthy adults with types Ia and Ib group B streptococcal polysaccharide-tetanus toxoid conjugate vaccines.
- Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14.
- Quantitative determination of immunoglobulin G specific for group B streptococcal beta C protein in human maternal serum.
- Phenotypic diversity in the alpha C protein of group B streptococci.
- Structural determination and immunochemical characterization of the type V group B Streptococcus capsular polysaccharide.
- Immunochemical characterization of two surface polysaccharides of Bacteroides fragilis.
- An oligosaccharide-tetanus toxoid conjugate vaccine against type III group B Streptococcus.
- Response to type III polysaccharide in women whose infants have had invasive group B streptococcal infection.
- Immunogenicity in animals of a polysaccharide-protein conjugate vaccine against type III group B Streptococcus.
- Antibody recognition of the type 14 pneumococcal capsule. Evidence for a conformational epitope in a neutral polysaccharide.
- Intraperitoneal host cellular responses and in vivo killing of Bacteroides fragilis in a bacterial containment chamber.
- Bacteroides vulgatus outer membrane antigens associated with carrageenan-induced colitis in guinea pigs.
- A model of high-affinity antibody binding to type III group B Streptococcus capsular polysaccharide.
- Immunization of pregnant women with a polysaccharide vaccine of group B streptococcus.
- Definition of a bacterial virulence factor: sialylation of the group B streptococcal capsule.
- Isolation and characterization of type IV group B Streptococcus capsular polysaccharide.
- A monoclonal antibody identifies a protective C-protein alpha-antigen epitope in group B streptococci.
- Transposon mutagenesis of type III group B Streptococcus: correlation of capsule expression with virulence.
- Neonatal mouse model of group B streptococcal infection.
- The capsular polysaccharide of Bacteroides fragilis as a virulence factor: comparison of the pathogenic potential of encapsulated and unencapsulated strains.
- Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters.
- Immunogenicity of polysaccharides from type III, group B Streptococcus.
- Protective efficacy of immunization with capsular antigen against experimental infection with Bacteroides fragilis.
- Immunochemical analysis and immunogenicity of the type II group B streptococcal capsular polysaccharide.
- Class specificity of naturally acquired and vaccine-induced antibody to type III group B streptococcal capsular polysaccharide: determination with a radioimmunoprecipi...
- Evidence for T cell-dependent immunity to Bacteroides fragilis in an intraabdominal abscess model.
- Antibody-independent classical pathway-mediated opsonophagocytosis of type Ia, group B streptococcus.
- NMR and molecular dynamics studies of the conformational epitope of the type III group B Streptococcus capsular polysaccharide and derivatives.
- Structure-function relationships for polysaccharide-induced intra-abdominal abscesses.
- Bacterial structure and functional relation to abscess formation.
- Measurement of human antibodies to type III group B Streptococcus.
- Safety and immunogenicity of capsular polysaccharide-tetanus toxoid conjugate vaccines for group B streptococcal types Ia and Ib.
- Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.
- Inactivation of the alpha C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus.
- A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease.
- Structural characterization of two surface polysaccharides of Bacteroides fragilis.
Schools
University of Illinois At Chicago College of Medicine
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
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Boston University Medical Center -
Brigham and Women's Hospital -
NYU School of Medicine -
University of Illinois College of Medicine
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