Director of Investigative Pathology

Pathology

Diego H. Castrillon practices Pathology. He studied medicine at University of Texas Southwestern Medical School. He over the years received 2 awards: "Vernie A. Stembridge, M.D., Distinguished Chair in Pathology" and "Elected Member". Doctor Diego H. Castrillon, MD is a published doctor. He has 49 publications published. The most current publication "Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer."

Publications

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• Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.
• Regulation of FOXO3 subcellular localization by Kit ligand in the neonatal mouse ovary.
• Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression.
• Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.
• Screening and familial characterization of copy-number variations in NR5A1 in 46,XY disorders of sex development and premature ovarian failure.
• Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis.
• FOXO1/3 Depletion in Granulosa Cells Alters Follicle Growth, Death and Regulation of Pituitary FSH.
• Monitoring Tumorigenesis and Senescence In Vivo with a p16(INK4a)-Luciferase Model.
• Errata "Insights into Primary Ovarian Insufficiency through Genetically Engineered Mouse Models".
• Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.
• Insights into Primary Ovarian Insufficiency through Genetically Engineered Mouse Models.
• Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia.
• Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
• Pathology quiz case 2: salivary duct carcinoma (SDC) of the parotid gland with mucinous differentiation.
• Mouse models of uterine corpus tumors: clinical significance and utility.
• FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.
• Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation.
• Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.
• Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.
• Somatic LKB1 mutations promote cervical cancer progression.
• Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.
• Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth.
• DNA methyltransferase loading, but not de novo methylation, is an oocyte-autonomous process stimulated by SCF signalling.
• Differential roles of telomere attrition in type I and II endometrial carcinogenesis.
• Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.
• Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
• A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
• Simplifying the preevacuation testing strategy for patients with molar pregnancy.
• Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.
• Generation of a germ cell-specific mouse transgenic Cre line, Vasa-Cre.
• FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription.
• FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
• FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
• Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling.
• Regulation of oxidative stress by the anti-aging hormone klotho.
• Duration of human chorionic gonadotropin surveillance for partial hydatidiform moles.
• Complete hydatidiform mole retaining a chromosome 11 of maternal origin: molecular genetic analysis of a case.
• Immunohistochemistry for the imprinted gene product IPL/PHLDA2 for facilitating the differential diagnosis of complete hydatidiform mole.
• Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a.
• Biomarkers in diagnostic obstetric and gynecologic pathology: a review.
• Constitutive telomerase expression promotes mammary carcinomas in aging mice.
• p16(INK4a) and p53 deficiency cooperate in tumorigenesis.
• Ploidy and imprinting in hydatidiform moles. Complementary use of flow cytometry and immunohistochemistry of the imprinted gene product p57KIP2 to assist molar classif...
• Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.
• VASA is a specific marker for both normal and malignant human germ cells.
• Distinction between endometrial and endocervical adenocarcinoma: an immunohistochemical study.
• The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues.
• Gonadal expression of foxo1, but not foxo3, is conserved in diverse Mammalian species.

Schools

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• University of Texas Southwestern Medical Center At Dallas

Doctors Specialties

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• Surgical (Selective) Pathology
• Pathology

Accepted Insurances

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Awards

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• Vernie A. Stembridge, M.D., Distinguished Chair in Pathology
• Elected Member

Education

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• Brigham and Women's Hospital
• University of Texas Southwestern Medical School

Hospital

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• University of Texas Southwestern Medical Center

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