Professor, Pediatrics, UCSD School of Medicine
Pediatric Hematology & Oncology
Dr. Donald L. Durden, MD
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Donald Durden is an expert in the field of Pediatric Hematology & Oncology. He went to medical school at University of Miami Miller School of Medicine. University of Miami Miller School of Medicine is ranked 45 in research and 0 in primary care medicine He received awards:"Cancer Working Group", "Goldhirsh Foundation Award", "Aflac Endowed Professo", "Distinguished Cancer Scholar Award", "Society for Pediatric Research", "Stop Cancer Research Career Development Award", "National Research Service Award", "American Cancer Society Postdoctoral Fellowship" and "Sigma Xi". Doctor Donald L. Durden, MD is a published physician as well. He has 64 publications published. The latest was: Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling.
Publications
- Vascular remodeling underlies rebleeding in hemophilic arthropathy.
- Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma.
- A Macrophage-Dominant PI3K Isoform Controls Hypoxia-Induced HIF1α and HIF2α Stability and Tumor Growth, Angiogenesis, and Metastasis.
- MDM2 regulates hypoxic HIF1α stability in an E3 ligase proteasome and PTEN-PI-3 kinase-AKT dependent manner.
- PTEN and PI-3 kinase inhibitors control LPS signaling and the lymphoproliferative response in the CD19+ B cell compartment.
- PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.
- Synthesis and Cancer Stem Cell-Based Activity of Substituted 5-Morpholino-7H-thieno[3,2-b]pyran-7-ones Designed as Next Generation PI3K Inhibitors.
- An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.
- The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention.
- Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma.
- Regulation of XIAP translation and induction by MDM2 following irradiation.
- Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity.
- Expression of RAC2 in endothelial cells is required for the postnatal neovascular response.
- The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration.
- A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity.
- Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.
- CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation.
- Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase.
- Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms.
- 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis.
- CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity.
- PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma.
- Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase.
- Rac2 specificity in macrophage integrin signaling: potential role for Syk kinase.
- PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.
- Ceramide signaling in fenretinide-induced endothelial cell apoptosis.
- SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
- PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.
- PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac.
- Rac2 controls tumor growth, metastasis and m1-m2 macrophage differentiation in vivo.
- Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model.
- In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells.
- PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells.
- Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors.
- Treatment of collagen induced arthritis in DBA/1 mice with L-asparaginase.
- PI-3 kinase-PTEN signaling node: an intercept point for the control of angiogenesis.
- A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth.
- Mouse mammary tumor virus (MMTV) antigen(s) are present on B lymphocytes of BALB/c mice.
- Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.
- Kinetic analysis of hepatotoxicity associated with antineoplastic asparaginases.
- Glutaminase-free asparaginase from vibrio succinogenes: an antilymphoma enzyme lacking hepatotoxicity.
- Comparison of the immunosuppressive effects of asparaginases from Escherichia coli and Vibrio succinogenes.
- Characterization of the effects of asparaginase from Escherichia coli and a glutaminase-free asparaginase from Vibrio succinogenes on specific ell-mediated cytotoxicity.
- Alteration in spleen lymphoid populations associated with specific amino acid depletion during L-asparaginase treatment.
- Protein-tyrosine kinase p72syk in Fc gamma RI receptor signaling.
- The Fc gamma RI receptor signals through the activation of hck and MAP kinase.
- Lipopolysaccharide stimulates the tyrosine phosphorylation of mitogen-activated protein kinases p44, p42, and p41 in vascular endothelial cells in a soluble CD14-depen...
- Protein tyrosine phosphatase inhibitors block myeloid signal transduction through the Fc gamma RI receptor.
- Serine/threonine phosphorylation of the gamma-subunit after activation of the high-affinity Fc receptor for immunoglobulin G.
- A role for Shc, Grb2, and Raf-1 in FcgammaRI signal relay.
- Differential activation of the tyrosine kinases ZAP-70 and Syk after Fc gamma RI stimulation.
- Protein tyrosine phosphatase inhibitors in Fc gamma RI-induced myeloid oxidant signaling.
- CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling.
- SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling.
- Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc rece...
- Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling.
- Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages.
- Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling.
- High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide ad...
- Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide.
- PTEN controls tumor-induced angiogenesis.
- Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin.
- A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis.
Schools
University of Miami School of Medicine
St Christophers Hospital Chldn
University Of Wa School Of Med
University Wa Med Center
Conditions Treated
- Acute Leukemia
- Deep Vein Thrombosis (DVT)
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Cancer Working Group
- Goldhirsh Foundation Award
- Aflac Endowed Professo
- Distinguished Cancer Scholar Award
- Society for Pediatric Research
- Stop Cancer Research Career Development Award
- National Research Service Award
- American Cancer Society Postdoctoral Fellowship
- Sigma Xi
Education
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University of Washington -
University of Miami Miller School of Medicine -
University of Miami School of Medicine -
University of South Florida
Hospital
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UC San Diego Health -
Rady Children's Hospital - San Diego
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