Physician

Medical Genetics

Donald L. Rucknagel is an expert in the field of Medical Genetics. He went to Washington University School of Medicine in St. Louis. Donald Rucknagel is a published physician. He published 100 publications, including: 'Time-dependent changes in the density and hemoglobin F content of biotin-labeled sickle cells.' Donald Rucknagel accepts all Medicare patients.

Publications

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• The effect of fetal hemoglobin on the survival characteristics of sickle cells.
• Phosphatidylserine externalization in sickle red blood cells: associations with cell age, density, and hemoglobin F.
• Hemolytic mechanism in sickle cell-Hgb C disease.
• Regulation of oxygen affinity by quaternary enhancement: does hemoglobin Ypsilanti represent an allosteric intermediate?
• Sickle-cell nephropathy: MR imaging.
• alpha-Thalassemia and HbF concentration in sickle cell anemia.
• The Seminole Indians of Florida: morphology and serology.
• Development of a somatic mutation screening system using Hb mutants. IV. Successful detection of red cells containing the human frameshift mutants Hb Wayne and Hb Cran...
• Bone marrow transplantation in a young child with sickle cell anemia.
• Sarcoidosis in a child with sickle cell anemia.
• Pre- and post-stroke MRI and neuropsychological studies in sickle cell disease: a case study.
• Urinary urocanic acid in man: the identification of urocanic acid and the comparative excretions of urocanic acid and N-formiminoglutamic acid after oral histidine in ...
• QUANTITATIVE STUDIES ON A2, SICKLE CELL, AND FETAL HEMOGLOBINS IN NEGROES WITH MONGOLISM, WITH OBSERVATIONS ON TRANSLOCATION MONGOLISM IN NEGROES.
• THE CHARACTERIZATION OF HEMOGLOBIN SHIMONOSEKI.
• CURRENT CONCEPTS OF THE GENETICS OF THALASSEMIA.
• THE COEXISTENCE OF THE GENES FOR HEMOGLOBIN E AND ALPHA-THALASSEMIA IN THAIS, WITH RESULTANT SUPPRESSION OF HEMOGLOBIN E SYNTHESIS.
• STUDIES ON THE DISTRIBUTION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY, THALASSEMIA, AND OTHER GENETIC TRAITS IN THE COASTAL AND MOUNTAIN VILLAGES OF CYPRUS.
• FURTHER EVIDENCE OF LINKAGE BETWEEN THE BETA AND DELTA LOCI GOVERNING HUMAN HEMOGLOBIN AND THE POPULATION DYNAMICS OF LINKED GENES.
• Hemoglobin Porto Alegre, a possible polymer of normal hemoglobin in a Caucasian Brazilian family.
• The abnormality of the primary structure of hemoglobin Shimonoseki.
• In vivo study of the sickle cell phenomenon.
• Hereditary benign intraepithelial dyskeratosis. II. Oral manifestations and hereditary transmission.
• Paper electrophoretic survey of hemoglobins of American Indians.
• Progress and prospects for the acute chest syndrome of sickle cell anemia.
• The survival characteristics of dense sickle cells.
• Time-dependent changes in the density and hemoglobin F content of biotin-labeled sickle cells.
• Dehydration of transferrin receptor-positive sickle reticulocytes during continuous or cyclic deoxygenation: role of KCl cotransport and extracellular calcium.
• Deoxygenation-induced changes in sickle cell-sickle cell adhesion.
• Simultaneous occurrence of rib infarction and pulmonary infiltrates in sickle cell disease patients with acute chest syndrome.
• Fat embolism syndrome associated with asthma and sickle cell-beta(+)-thalassemia.
• X-linked sideroblastic anemia: identification of the mutation in the erythroid-specific delta-aminolevulinate synthase gene (ALAS2) in the original family described by...
• Hemoglobin F-Cincinnati, alpha 2G gamma 2 41(C7) Phe-->Ser in a newborn with cyanosis.
• Incentive spirometry to prevent acute pulmonary complications in sickle cell diseases.
• Fetal hemoglobin and potassium in isolated transferrin receptor-positive dense sickle reticulocytes.
• Duplication 8p syndrome: studies in a family with a reciprocal translocation between chromosomes 8 and 12.
• Cord blood screening for hemoglobin disorders by high-performance liquid chromatography.
• The proportion of Hb A2 is higher in sickle cell trait than in normal homozygotes.
• Highly sensitive and rapid gene mapping using miniaturized blot hybridization: application to prenatal diagnosis.
• A decade of screening in the hemoglobinopathies: is a national program to prevent sickle cell anemia possible?
• Phenazopyridine induced methaemoglobinaemia associated with decreased activity of erythrocyte cytochrome b5 reductase.
• Hemoglobin SO Arab and hemoglobin CO Arab diseases. Clinical and laboratory study.
• Transfer of small plasmid DNA fragments from polyacrylamide gels onto nitrocellulose paper.
• Further studies on the Xavante Indians. V. Genetic variability in some serum and erythrocyte enzymes, hemoglobin, and the urinary excretion of beta-aminoisobutyric acid.
• Blood group investigations on the Carolinians and Chamorros of Saipan.
• Two more examples of Hb Porto Alegre, alpha-2 beta-2 9 Ser leads to Cys in Belém, Brazil.
• Familial occurrence of asthma, nasal polyps and aspirin intolerance.
• Duplication of structural genes for hemoglobin alpha and beta chains in man.
• The genetics of sickle cell anemia and related syndromes.
• Erythrocytes: pits and vacuoles as seen with transmission and scanning electron microscopy.
• The Northern and Southeastern Ojibwa: serum proteins and red cell enzyme systems.
• Haemoglobin inkster (alpha2 85aspartic acid leads to valine beta2) coexisting with beta-thalassaemia in a Caucasian family.
• The Bangkok variant of the serum group-specific component (Gc) and the frequency of the Gc alleles in Thailand.
• Further studies of the Xavante Indians. 8. Some observations on blood, urine, and stool specimens.
• Density ultracentrifugation of sickle cells during and after pain crisis: increased dense echinocytes in crisis.
• The increasing complexity of sickle cell anemia.
• The occurrence of the alpha G-Philadelphia-globin allele on a double-locus chromosome.
• Heterogeneity of sickle-cell anemia based on a profile of hematological variables.
• Comparative pathophysiology in sickle cell disease and the thalassemias.
• Long survival in sickle cell anemia.
• Immunologic quantification of fetal hemoglobin in sickle cell anemia.
• Clinical implications of recent advances in hemoglobin disorders.
• Genetic linkage between structural loci for albumin and group specific component (Gc).
• Mild homozygous beta-thalassemia. Further evidence for the heterogeneity of beta-thalassemia genes.
• Proliferation of human abnormal hemoglobins.
• The Thai variant and the distribution of alleles of 6-phosphogluconate dehydrogenase and the distribution of glucose 6-phosphate dehydrogenase deficiency in Thailand.
• Familial erythrocytosis. A description of three families, one with hemoglobin Ypsilanti.
• The contribution of analytical chemistry to the genetic revolution.
• Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians.
• Oxygen equilibrium of hemoglobin E.
• Amino acid substitution in two identical inherited human serum albumin variants: albumin Oliphant and albumin Ann Arbor.
• Defective erythrocyte pyruvate kinase with impaired kinetics and reduced optimal activity.
• Biosynthesis of hemoglobin Ann Arbor: evidence for catabolic and feedback regulation.
• Evaluation of glycosylated hemoglobin in the management of young patients with insulin-dependent diabetes mellitus.
• Painful crisis and dense echinocytes: effects of hydration and vasodilators.
• Evaluation of the yield stress of normal blood as a function of fibrinogen concentration and hematocrit.
• Fetal hemoglobin concentration predicts disease severity in children with sickle cell anemia.
• The relationship between fetal hemoglobin and disease severity in children with sickle cell anemia.
• Influence of plasma and red cell factors on the rheologic properties of oxygenated sickle blood during clinical steady state.
• Hb Port Huron [alpha 56 (E5)Lys----ARG]: a new alpha chain variant.
• Rib infarcts and acute chest syndrome in sickle cell diseases.
• Mutagenic dissection of hemoglobin cooperativity: effects of amino acid alteration on subunit assembly of oxy and deoxy tetramers.
• The interaction of alpha-thalassaemia and haemoglobin G Philadelphia.
• Comparison of methodologies for thalassemia screening by Hb A2 quantitation.
• A heterozygote for Hb S beta, Hb C beta and Hb G Philadelphia beta in a family presenting evidence for heterogeneity of hemoglobin alpha chain loci.
• Trimodality in the proportion of hemoglobin G Philadelphia in heterozygotes: evidence for heterogeneity in the number of human alpha chain loci.
• Hemoglobin Wayne: a frameshift mutation detected in human hemoglobin alpha chains.
• Primary amyloidosis associated with Gaucher''s disease.
• Increased bone marrow blood flow in sickle cell anemia demonstrated by thallium-201 and Tc-99m human albumin microspheres.
• Polymorphism in the number of hemoglobin alpha-chain loci and mechanisms governing the balance of chain synthesis.
• Synthesis of haemoglobin Wayne in erythroid cells.
• Hemoglobin D Ibadan trait in combination with sigma beta thalassemia.
• Genetic mechanisms contributing to the expression of the human hemoglogin loci.
• Proteolytic activity in erythrocyte precursors.
• Fetal hemoglobin and alpha-fetoprotein in various malignancies.
• Immunologic studies of hemoglobins. III. Fetal hemoglobin changes in the circulation of pregnant women.
• Hemoglobin I: an inherited hemoglobin anomaly.
• Vagal sensitivity and the production of auricular fibrillation in experimentally hyperthyroid dogs.
• Toxicity of mono methyl ether of dipropylene glycol (dowanol 5?B) in studies on auricular fibrillation.
• The role of rib infarcts in the acute chest syndrome of sickle cell diseases.

Schools

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• Washington Center School of Medicine

• Duke University

• NihDental Res Institute

• University Mich Med School

• University Of Pittsburgh

Doctors Specialties

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• Clinical Genetics
• Medical Genetics

Accepted Insurances

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Education

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• University of Michigan Hospitals and Health Centers
• Duke University Hospital
• Washington University School of Medicine in St. Louis

Hospital

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• University of Cincinnati Medical Center

Drug Facts

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NPI NUMBER		1831394675
NPPES Provider LastName		RUCKNAGEL
NPPES Provider FirstName		DONALD
NPPES Provider ZIPCode		452192364
NPPES Provider State		OH
Specialty Description		Hematology
Total Claim Count		642.0
Distinct Opioid Count		7.0
Opioid Claim Count		452.0
Percent Opioid Claims		70.4

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Medicare Facts

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National Provider Identifier [NPI]	1831394675
Last Name Of The Provider	RUCKNAGEL
First Name Of The Provider	DONALD
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