Professor, Pathology and Laboratory Medicine, Perelman School of Medicine

Pathology

Donald Siegel is an expert in the field of Pathology. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. He over the years received 21 awards: "Elected Fellow", "Elected to The Academy of Master Clinicians", "CMS Meaningful Use Stage 1 Certification", "Health Care Hero Awardee", "Philadelphia Antiques Show Proceeds Awardee, Board of Womens Visitors", "Pennsylvania Biotechnology Greenhouse Award", "Christian R. and Mary F. Lindback Foundation Award for Distinguished Teaching", "Elected to John Morgan Society", "Leonard Berwick Memorial Teaching Award", "Peter C. Nowell Teaching Award, Department of Pathology & Laboratory Medicine", "Scholar", "Research Award", "Basil OConnor Scholar Research Award", "Clinical Investigator Award (K08)", "Julius Erving Research Award", "Berwick Resident Teaching Award, Department of Pathology & Laboratory Medicine", "Young Investigator Award (2), Annual Meeting", "Young Investigator Award, First Prize Recipient", "Measey Foundation Scholar", "Elected to Sigma Xi" and "NIH Pre-Doctoral Fellowship in the Laboratory of Dr. Daniel Branton". Donald Siegel is also a published doctor. He has 46 paper published. The most recent paper is: Only selected light chains combine with a given heavy chain to confer specificity for a model glycopeptide antigen. Donald L. Siegel, MD accepts all Medicare patients.

Publications

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• Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy.
• Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycat...
• Anaphylactoid-like reactions in a patient with HyperLp(a)lipidemia undergoing LDL apheresis with dextran sulfate adsorption and herbal therapy with the spice turmeric.
• Generation and validation of canine single chain variable fragment phage display libraries.
• Rapid isolation of high-affinity human antibodies against the tumor vascular marker Endosialin/TEM1, using a paired yeast-display/secretory scFv library platform.
• Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity.
• Impact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors.
• Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody.
• Selecting antibodies to cell-surface antigens using magnetic sorting techniques.
• Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation.
• Mechanisms of action of therapeutics in idiopathic thrombocytopenic purpura.
• Mechanism of genetic complementation of ammonium transport in yeast by human erythrocyte Rh-associated glycoprotein.
• On the mechanism of staphylococcal protein A immunomodulation.
• Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display.
• Developing phage display tools for use in transfusion medicine.
• Targeting pemphigus autoantibodies through their heavy-chain variable region genes.
• Phage display-based molecular methods in immunohematology.
• Post-transplant outcomes of induction therapy for myeloma: thalidomide and dexamethasone versus doxorubicin, vincristine, and dexamethasone prior to high-dose melphala...
• Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies.
• Translational applications of antibody phage display.
• Phage display tools for blood typing.
• Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis with diaphragmatic involvement in a patient with respiratory failure.
• Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus.
• Update on the cloning of monoclonal anti-desmoglein antibodies from human pemphigus patients: implications for targeted therapy.
• Isolation of cell surface-specific human monoclonal antibodies using phage display and magnetically-activated cell sorting: applications in immunohematology.
• Genetic and immunological properties of phage-displayed human anti-Rh(D) antibodies: implications for Rh(D) epitope topology.
• Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies.
• Long-term event-free survivors after high-dose therapy and autologous stem-cell transplantation for low-grade follicular lymphoma.
• Isolation of an IgG anti-B from a human Fab-phage display library.
• Isolation of human anti-red blood cell antibodies by repertoire cloning.
• Expression and characterization of recombinant anti-Rh(D) antibodies on filamentous phage: a model system for isolating human red blood cell antibodies by repertoire c...
• Research and clinical applications of antibody phage display in transfusion medicine.
• Construction of bacteriophage expressing mouse monoclonal Fab fragments directed against the human MN glycophorin blood group antigens.
• Prognostic value of FDG-PET scan imaging in lymphoma patients undergoing autologous stem cell transplantation.
• Only selected light chains combine with a given heavy chain to confer specificity for a model glycopeptide antigen.
• The human immune response to red blood cell antigens as revealed by repertoire cloning.
• Section 5: Structural/genetic analysis of mAbs to blood group antigens. Coordinator''s report.
• Purification of a secreted form of recombinant rabies virus glycoprotein: comparison of two affinity tags.
• Second auto-SCT is safe and effective salvage therapy for relapsed multiple myeloma.
• A molecular approach for isolating high-affinity Fab fragments that are useful in blood group serology.
• Discriminating rejection from CMV infection in renal allograft recipients using flow cytometry.
• Recombinant monoclonal antibody technology.
• Universal WBC reduction.
• Inappropriate testing for diarrheal diseases in the hospital.
• The limitations of site-directed mutagenesis in the localization of Rh D epitopes.

Schools

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• Perelman School of Medicine University of Pennsylvania

• University Penn Hospital

Doctors Specialties

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• Clinical Pathology
• Pathology

Accepted Insurances

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Awards

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• Elected Fellow
• Elected to The Academy of Master Clinicians
• CMS Meaningful Use Stage 1 Certification
• Health Care Hero Awardee
• Philadelphia Antiques Show Proceeds Awardee, Board of Women’s Visitors
• Pennsylvania Biotechnology Greenhouse Award
• Christian R. and Mary F. Lindback Foundation Award for Distinguished Teaching
• Elected to John Morgan Society
• Leonard Berwick Memorial Teaching Award
• Peter C. Nowell Teaching Award, Department of Pathology & Laboratory Medicine
• Scholar
• Research Award
• Basil O’Connor Scholar Research Award
• Clinical Investigator Award (K08)
• Julius Erving Research Award
• Berwick Resident Teaching Award, Department of Pathology & Laboratory Medicine
• Young Investigator Award (2), Annual Meeting
• Young Investigator Award, First Prize Recipient
• Measey Foundation Scholar
• Elected to Sigma Xi
• NIH Pre-Doctoral Fellowship in the Laboratory of Dr. Daniel Branton

Education

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• University of Pennsylvania
• University of Pennsylvania Health System
• Perelman School of Medicine at the University of Pennsylvania
• Harvard University
• Brown University

Hospital

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• Hospital of the University of Pennsylvania
• Penn Presbyterian Medical Center

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1396773446
Last Name Of The Provider	SIEGEL
First Name Of The Provider	DONALD
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