Director, Blood and Marrow Transplant Program
Pediatric Hematology & Oncology
Dr. Emmanuel Katsanis, MD
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Emmanuel Katsanis practices Pediatric Hematology & Oncology. He received 14 awards: "Americas Top Oncologists (Consumers Research Council of America)", "Leading Edge Researcher Award", "Americas Top Pediatricians (Consumers Research Council of America)", "Clinical Oncology Career Development Award", "Irvine McQuarrie Research Scholar Award", "Young Investigator Award", "Fellowship Award", "Variety Club Fellowship", "First Place Award", "Outstanding Pediatric Fellow Award", "Gordon E. Richard Award", "Award for Best Research Presentation by a Pediatric Resident", "Wyeth Award for Excellence Achieved in Research" and "Louise Thomas Endowed Chair in Pediatric Cancer Research". Emmanuel Katsanis is also a published doctor. He has 89 publication published. The most recent publication is: Molecular chaperones: biology and prospects for pharmacological intervention.
Publications
- The complex pathophysiology of acquired aplastic Anemia.
- Pediatric secondary chronic myeloid Leukemia following cardiac transplantation for anthracycline-induced cardiomyopathy.
- Outcomes after Hematopoietic Stem Cell Transplant for Children with I-Cell Disease.
- PIAS1 and STAT-3 impair the tumoricidal potential of IFN-γ-stimulated mouse dendritic Cells generated with IL-15.
- Activated MHC-mismatched T helper-1 lymphocyte infusion enhances GvL with limited GvHD.
- Chemotherapeutic targeting of Myeloid-derived suppressor cells.
- Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T Cell Transfer in Breast Cancer.
- The 'peptidome' of tumour-derived chaperone-rich cell lysate anti-Cancer vaccines reveals potential tumour antigens that stimulate tumour immunity.
- Prolonged remission of advanced bronchoalveolar adenocarcinoma in a dog treated with autologous, tumour-derived chaperone-rich Cell lysate (CRCL) vaccine.
- Dendritic cell tumor killing activity and its potential applications in Cancer immunotherapy.
- Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-beta-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells.
- Cytotoxic and antigen presenting functions of T helper-1-activated dendritic Cells.
- Late effects in adult survivors of pediatric Cancer: a guide for the primary care physician.
- Diagnostic and treatment challenges for the pediatric hematologist oncologist in endemic areas for coccidioidomycosis.
- Endoplasmic reticulum chaperones and their roles in the immunogenicity of Cancer vaccines.
- Stressed apoptotic tumor Cells stimulate dendritic Cells and induce specific cytotoxic T Cells.
- Exogenous stress proteins enhance the immunogenicity of apoptotic tumor Cells and stimulate antitumor immunity.
- Tumor-derived, chaperone-rich Cell lysate activates dendritic Cells and elicits potent antitumor immunity.
- Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines against a variety of Cancers.
- Imatinib mesylate effectively combines with chaperone-rich cell lysate-loaded dendritic cells to treat bcr-abl+ murine Leukemia.
- Induction of BCR-ABL-specific immunity following vaccination with chaperone-rich Cell lysates derived from BCR-ABL+ tumor Cells.
- Cargo from tumor-expressed albumin inhibits T-Cell activation and responses.
- Chaperone-rich cell lysates, Immune activation and tumor vaccination.
- Vesiculated alpha-tocopheryl succinate enhances the anti-tumor effect of dendritic Cell vaccines.
- Peritransplantation vaccination with chaperone-rich cell lysate induces antiLeukemia immunity.
- Tumor-derived CD4(+)CD25(+) regulatory T Cell suppression of dendritic Cell function involves TGF-beta and IL-10.
- Apoptotic, necrotic, or fused tumor Cells: an equivalent source of antigen for dendritic Cell loading.
- Natural killer Cells play a key role in the antitumor immunity generated by chaperone-rich Cell lysate vaccination.
- CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active Disease.
- Chaperone-rich cell lysate embedded with BCR-ABL peptide demonstrates enhanced anti-tumor activity against a murine BCR-ABL positive Leukemia.
- The inhibition of TNF-alpha anti-tumoral properties by blocking antibodies promotes tumor growth in a rat model.
- Chaperone-rich tumor Cell lysate-mediated activation of antigen-presenting Cells resists regulatory T Cell suppression.
- A chaperone protein-enriched tumor cell lysate vaccine generates protective humoral immunity in a mouse breast Cancer model.
- Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens.
- Imatinib mesylate inhibits CD4+ CD25+ regulatory T Cell activity and enhances active immunotherapy against BCR-ABL- tumors.
- Killer dendritic cells and their potential for Cancer immunotherapy.
- Signaling pathways induced by a tumor-derived vaccine in antigen presenting Cells.
- Peroxynitrite-dependent killing of Cancer cells and presentation of released tumor antigens by activated dendritic cells.
- Personalized dendritic Cell-based tumor immunotherapy.
- Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat Leukemia.
- Cytotoxic dendritic cells generated from Cancer patients.
- Immunologic effects of rituximab on the human spleen in Immune thrombocytopenia.
- Th-1 lymphocytes induce dendritic Cell tumor killing activity by an IFN-?-dependent mechanism.
- The dendritic Cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.
- Human ovarian tumour-derived chaperone-rich Cell lysate (CRCL) elicits T Cell responses in vitro.
- Depot characteristics and biodistribution of interleukin-2 liposomes: importance of route of administration.
- Importance in timing of cyclophosphamide on the enhancement of interleukin-2-induced cytolysis.
- Anti-tumor vaccine adjuvant effects of IL-2 liposomes in mice immunized against MCA-102 sarcoma.
- Antitumor effects of interleukin 2 liposomes and anti-CD3-stimulated T-Cells against murine MCA-38 hepatic metastasis.
- Proliferation and cytolytic function of anti-CD3 + interleukin-2 stimulated peripheral blood mononuclear Cells following bone marrow transplantation.
- Increased local antitumor effects of interleukin 2 liposomes in mice with MCA-106 sarcoma pulmonary metastases.
- Thyroid dysfunction following bone marrow transplantation: long-term follow-up of 80 pediatric patients.
- Treatment of acquired severe aplastic Anemia.
- Prevalence and significance of mild bleeding Disorders in children with recurrent epistaxis.
- Neutrophilic eccrine hidradenitis in Acute myelomonocytic leukemia.
- Hemoglobin E: a common hemoglobinopathy among children of Southeast Asian origin.
- Systemic lupus erythematosus and Sickle hemoglobinopathies: a report of two cases and review of the literature.
- B7-1 expression decreases tumorigenicity and induces partial systemic immunity to murine neuroblastoma deficient in major histocompatibility complex and costimulatory ...
- Short-term ex vivo activation of splenocytes with anti-CD3 plus IL-2 and infusion post-BMT into mice results in in vivo expansion of effector Cells with potent anti-ly...
- Transfection of the mouse ICAM-1 gene into murine neuroblastoma enhances susceptibility to lysis, reduces in vivo tumorigenicity and decreases ICAM-2-dependent killing.
- Interleukin-1 alpha administered after autologous transplantation: a phase I/II clinical trial.
- Infusions of interleukin-1 alpha after autologous transplantation for Hodgkin's Disease and non-Hodgkin's lymphoma induce effector cells with antilymphoma cytolytic ac...
- Retroperitoneal inoculation of murine neuroblastoma results in a reliable model for evaluation of the antitumor Immune response.
- Interleukin-2 gene transfer into murine neuroblastoma decreases tumorigenicity and enhances systemic immunity causing regression of preestablished retroperitoneal tumors.
- Irradiation of singly and doubly transduced murine neuroblastoma Cells expressing B7-1 and producing interferon-gamma reduces their capacity to induce systemic immunity.
- The multifaceted role of Th17 lymphocytes and their associated cytokines in Cancer.
- Effective immunization against neuroblastoma using double-transduced tumor Cells secreting GM-CSF and interferon-gamma.
- IL-15 administration following syngeneic bone marrow transplantation prolongs survival of Lymphoma bearing mice.
- Antitumor mechanisms of attenuated Salmonella typhimurium containing the gene for human interleukin-2: a novel antitumor agent?
- Unrelated donor bone marrow transplantation for children with Acute leukemia.
- Unrelated donor bone marrow transplantation for children and adolescents with aplastic anaemia or myelodysplasia.
- Interleukin-2 liposome inhalation therapy is safe and effective for dogs with spontaneous pulmonary metastases.
- The role of B7 costimulation by murine Acute myeloid leukemia in the generation and function of a CD8+ T-cell line with potent in vivo graft-versus-leukemia properties.
- Low dose subcutaneous interleukin-2 after autologous transplantation generates sustained in vivo natural killer Cell activity.
- Nebulized interleukin 2 liposomes: aerosol characteristics and biodistribution.
- Activated peripheral blood mononuclear Cells from patients receiving subcutaneous interleukin-2 following autologous stem Cell transplantation prolong survival of SCID...
- Molecular chaperones: biology and prospects for pharmacological intervention.
- Autologous stem Cell transplantation for high-risk pediatric solid tumors.
- Effects of geldanamycin, a heat-shock protein 90-binding agent, on T Cell function and T Cell nonreceptor protein tyrosine kinases.
- Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell Leukemia/lymphoma.
- Improved immunostimulatory function of bone marrow derived macrophages transduced with the granulocyte-macrophage colony stimulating factor gene.
- Patterns of hepatic and splenic colonization by an attenuated strain of Salmonella typhimurium containing the gene for human interleukin-2: a novel anti-tumor agent.
- Interleukin-2 secretion by transduced and unselected BDL-2 lymphoma results in increased survival in mice with previously established disseminated Disease.
- Tumor-derived multiple chaperone enrichment by free-solution isoelectric focusing yields potent antitumor vaccines.
- Invasion and metastasis of a mammary tumor involves TGF-beta signaling.
- Dendritic-cell-peptide immunization provides immunoprotection against bcr-abl-positive Leukemia in mice.
- Stressed apoptotic tumor Cells express heat shock proteins and elicit tumor-specific immunity.
- T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1.
Schools
University of Athens College of Medicine School of Health Science National amp Kapodistrian
St Marys Hospmcgill University
Chldns Hospital University Ottawa
University Of Minnesota
Procedures Preformed
- HPC Transplantation (Stem Cell Transplant)
- Plasmapheresis
Conditions Treated
- Acute Leukemia
- Adrenal Gland Cancer
- Anemia
- Chronic Myeloid Leukemia (CML)
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- America’s Top Oncologists (Consumers’ Research Council of America)
- Leading Edge Researcher Award
- America’s Top Pediatricians (Consumers’ Research Council of America)
- Clinical Oncology Career Development Award
- Irvine McQuarrie Research Scholar Award
- Young Investigator Award
- Fellowship Award
- Variety Club Fellowship
- First Place Award
- Outstanding Pediatric Fellow Award
- Gordon E. Richard Award
- Award for Best Research Presentation by a Pediatric Resident
- Wyeth Award for Excellence Achieved in Research
- Louise Thomas Endowed Chair in Pediatric Cancer Research
Education
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McGill University -
University of Athens
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