Member, Brain Research Institute; Professor Emeritus, Psychiatry and Biobehavioral Sciences; Semel Institute (NPI), UCLA School of Medicine

Psychiatry

Ernest Noble is an expert in the field of Psychiatry. He researched medicine at Case Western Reserve University School of Medicine. He received 1 awards: "Whos Who in Medicine and Healthcare". Ernest P. Noble, MD is a published doctor as well. He has 100 publications published. The latest was: Acetylcholine (AcCh) uptake in cortical slabs taken from C57B1 mice after acute and/or chronic ethanol treatment.

Publications

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• Association of COMT and TPH-2 genes with DSM-5 based PTSD symptoms.
• Association of dopamine D2 receptor and leptin receptor genes with clinically severe obesity.
• Brain-specific epigenetic markers of schizophrenia.
• Effect of ethanol on neural cells grown in culture: interaction with plasma membrane ecto-5'-nucleotidase activity.
• Corticosterone response to ethanol in inbred strains of mice.
• Effects of long term ethanol ingestion on RNA metabolism by inner membranes of rat brain mitochondria.
• Effects of chronic ethanol ingestion on brain aminoacyl-tRNA synthestases and tRNA.
• Studies on the effects of chronic ethanol ingestion on the properties of rat brain ribosomes.
• Benzodiazepine binding characteristics of embryonic rat brain neurons grown in culture.
• Adrenocortical response to ethanol in mice: modification by chronic ethanol consumption.
• Factor structure of the state and trait versions of the depression adjective check lists.
• Alcohol and the aging process in social drinkers.
• Ethanol-induced conformational changes in rat brain microsomal membranes.
• The modification of the ethanol withdrawal syndrome in rats by di-n-propylacetate.
• Social drinking and cognitive function: a review.
• The comparative validity of eleven alcoholism typologies.
• Alcohol and the disruption of cognitive processes.
• Alcohol and affect in dyadic social interaction.
• The menstrual cycle: a double-blind study of symptoms, mood and behavior, and biochemical variables using enovid and placebo.
• Changes in neuropsychological performance during treatment for alcoholism.
• Substance abuse vulnerability and D2 receptor genes.
• Alcoholism and the D2 dopamine receptor gene.
• The sobering D2 story.
• Relationship between neuropsychological performance and alcohol consumption in alcoholics.
• The genetic transmission of alcoholism: implications for prevention.
• Developmental patterns of ganglioside sialosylation coincident with neuritogenesis in cultured embryonic chick brain neurons.
• EGF-induced neuritogenesis and correlated synthesis of plasma membrane gangliosides in cultured embryonic chick CNS neurons.
• H1-histaminergic activation of catecholamine release by chromaffin cells.
• Inhibition of neuritogenic ganglioside biosynthesis in chick brain neurons by calcium ionophore A23187.
• Alcoholism and the dopaminergic system: a review.
• Excitatory amino acids inhibit stimulated phosphoinositide hydrolysis in the rat prefrontal cortex.
• Inositol phospholipid hydrolysis in cultured astrocytes and oligodendrocytes.
• Postmortem changes in rat brain: studies on membrane-bound enzymes and receptors.
• Acetylcholine (AcCh) uptake in cortical slabs taken from C57B1 mice after acute and/or chronic ethanol treatment.
• Alcohol consumption and cognitive functioning in social drinkers.
• Pharmacological treatment for antisocial personality disorder alcoholics: a preliminary study.
• The DRD2 gene, smoking, and lung cancer.
• DRD2 gene and alcoholism.
• Neuropsychological consequences of posttreatment drinking behavior in male alcoholics.
• Lack of association between alcohol-dependence and D3 dopamine receptor gene in three independent samples.
• No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis.
• Personality characteristics of alcoholic fathers and their sons.
• Ethanol attenuation of ganglioside sialylation and neuritogenesis.
• The DRD2A?allele: a behavioural genetic risk factor in hepatitis C infection of persistent drug abusers.
• Stability of neuronal and glial marker enzymes in post-mortem rat brain.
• Recent developments in alcoholism:molecular biology and behavior.
• Ethanol exposure alters K+- but not bradykinin-induced dopamine release in PC12 cells.
• An atypical neurocognitive profile in alcoholic fathers and their sons.
• Isolation of nuclear proteins from human brains.
• Prenatal ethanol exposure reduces the effects of excitatory amino acids in the rat hippocampus.
• Regulation of phosphoinositide hydrolysis in cultured astrocytes by sphingosine and psychosine.
• The Sidney Cohen lectureship in drug abuse medicine. Alcohol, brain, and society.
• The D2 dopamine receptor gene: a review of association studies in alcoholism.
• Allelic association of human dopamine D2 receptor gene in alcoholism.
• Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism.
• Polymorphisms of the D2 dopamine receptor gene and alcoholism and other substance use disorders.
• Alcohol-induced alterations in phosphoinositide hydrolysis in astrocytes.
• Familial alcoholism and ERPs: differences in probability sensitivity?
• The DRD2 gene in psychiatric and neurological disorders and its phenotypes.
• Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele.
• Neuropsychological differences between sons of active alcoholic and non-alcoholic fathers.
• Event-related potentials in alcoholic fathers and their sons.
• Creativity in alcoholic and nonalcoholic families.
• D2 dopamine receptor TaqI A alleles in medically ill alcoholic and nonalcoholic patients.
• Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism.
• Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review.
• D2 dopamine receptor gene and obesity.
• The D2 dopamine receptor gene: a review of association studies in alcoholism and phenotypes.
• Genetic predisposition in alcoholism: association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics.
• The D(2) dopamine receptor A(1) allele and opioid dependence: association with heroin use and response to methadone treatment.
• D2 dopamine receptor polymorphism and brain regional glucose metabolism.
• Prolonged P300 latency in children with the D2 dopamine receptor A1 allele.
• Association of D2 dopamine receptor and alcohol dehydrogenase 2 genes with Polynesian alcoholics.
• The D2 dopamine receptor (DRD2) gene and family stress; interactive effects on cognitive functions in children.
• [3H]naloxone binding in the human brain: alcoholism and the TaqI A D2 dopamine receptor polymorphism.
• GABA(A) receptor beta 3 subunit gene and psychiatric morbidity in a post-traumatic stress disorder population.
• Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele.
• Haplotypes at the DRD2 locus and severe alcoholism.
• Reduced visuospatial performance in children with the D2 dopamine receptor A1 allele.
• D2 dopamine receptor gene and cigarette smoking: a reward gene?
• D2 and D4 dopamine receptor polymorphisms and personality.
• D2 dopamine receptor A1 allele in Alzheimer disease and aging.
• Association of the D2 dopamine receptor A1 allele with alcoholism: medical severity of alcoholism and type of controls.
• P3 in young boys as a predictor of adolescent substance use.
• Neuropsychological functioning in sons of active alcoholic, recovering alcoholic, and social drinking fathers.
• Allelic association of the D2 dopamine receptor gene with cocaine dependence.
• Extraversion. Interaction between D2 dopamine receptor polymorphisms and parental alcoholism.
• D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism.
• D(2) dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence.
• Advances in molecular genetics and the prevention and treatment of substance misuse: Implications of association studies of the A1 allele of the D2 dopamine receptor g...
• ANKK1/DRD2 locus variants are associated with rimonabant efficacy in aiding smoking cessation: pilot data.
• Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism.
• Smoking and schizophrenia: is symptom profile related to smoking and which antipsychotic medication is of benefit in reducing cigarette use?
• The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder.
• P300 development during adolescence: effects of DRD2 genotype.
• DRD2 genotypes and substance use in adolescent children of alcoholics.
• PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake.
• Effect of the TaqIA polymorphism on ethanol response in the brain.
• Genetic, personality, and environmental predictors of drug use in adolescents.

Schools

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• Case Western Reserve University School of Medicine

• Stanford University Hospital

Doctors Specialties

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• Other
• Psychiatry

Accepted Insurances

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Awards

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• Whos Who in Medicine and Healthcare

Education

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• Stanford University
• Case Western Reserve University School of Medicine

Hospital

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• Ronald Reagan UCLA Medical Center

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