Professor; Academic physician-scientist (basic research); Also Neurologist (Pediatric); Director, Center for Stem Cell and Regenerative Biology; Stem Cell Research Center and Core Facility
Neonat/Perinatology
Dr. Evan Y. Snyder, MD
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Doctor Evan Y. Snyder, MD is an expert in the field of Neonat/Perinatology. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. He received awards:"Whos Who in Medicine and Healthcare" and "Fellow (FAAP)". Evan Y. Snyder, MD is a published doctor and has 99 publications published. The lastest was: 'Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards.'
Publications
- Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards.
- Special issue on stem cells: "the end of the beginning".
- Aberrant production of tenascin-C in globoid cell leukodystrophy alters psychosine-induced microglial functions.
- Human Neural Stem Cells Survive Long Term in the Midbrain of Dopamine-Depleted Monkeys After GDNF Overexpression and Project Neurites Toward an Appropriate Target.
- Repair of Cartilage Defects in Arthritic Tissue with Differentiated Human Embryonic Stem Cells.
- Homing of Neural Stem Cells From the Venous Compartment Into a Brain Infarct Does Not Involve Conventional Interactions With Vascular Endothelium.
- Reparative effects of neural stem cells in neonatal rats with hypoxic-ischemic injury are not influenced by host gender.
- Two cells are better than one: Optimizing stem cell survival by co-grafting "helper" cells that offer regulated trophic support.
- Tissue plasminogen activator regulates Purkinje neuron development and survival.
- Identification of human embryonic progenitor cell targeting peptides using phage display.
- Deriving dopaminergic neurons for clinical use. A practical approach.
- MMP-3 mediates psychosine-induced globoid cell formation: Implications for leukodystrophy pathology.
- Three-dimensional scaffolding to investigate neuronal derivatives of human embryonic stem cells.
- A human embryonic stem cell-derived clonal progenitor cell line with chondrogenic potential and markers of craniofacial mesenchyme.
- Phosphoproteomic Analysis: An Emerging Role in Deciphering Cellular Signaling in Human Embryonic Stem Cells and Their Differentiated Derivatives.
- The intricate dance between repair and inflammation Introduction to special issue.
- Modeling complex neuropsychiatric disorders with human induced pluripotent stem cells.
- Overexpression of bHLH transcription factors enhances neuronal differentiation of foetal human neural progenitor cells in various ways.
- Self-renewal induced efficiently, safely, and effective therapeutically with one regulatable gene in a human somatic progenitor cell.
- The risk of putting something where it does not belong: Mesenchymal stem cells produce masses in the brain.
- Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury.
- Efficient derivation of human cardiac precursors and cardiomyocytes from pluripotent human embryonic stem cells with small molecule induction.
- Efficient derivation of human neuronal progenitors and neurons from pluripotent human embryonic stem cells with small molecule induction.
- Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling.
- Microarray-based transcriptional and epigenetic profiling of matrix metalloproteinases, collagens, and related genes in cancer.
- Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host.
- Derivation of vasculature from embryonic stem cells.
- Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency.
- Early acquisition of neural crest competence during hESCs neuralization.
- Culture and manipulation of neural stem cells.
- Cross-talk between stem cells and the dysfunctional brain is facilitated by manipulating the niche: evidence from an adhesion molecule.
- A safer stem cell: on guard against cancer.
- Neural stem cell transplantation benefits a monogenic neurometabolic disorder during the symptomatic phase of disease.
- Culture system for rodent and human oligodendrocyte specification, lineage progression, and maturation.
- Important precautions when deriving patient-specific neural elements from pluripotent cells.
- Phosphoproteomic analysis of human embryonic stem cells.
- The dynamics of long-term transgene expression in engrafted neural stem cells.
- Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors.
- Long-term multilayer adherent network (MAN) expansion, maintenance, and characterization, chemical and genetic manipulation, and transplantation of human fetal forebra...
- Neuroimaging as a basis for rational stem cell therapy.
- Neural stem/progenitor cells modulate immune responses by suppressing T lymphocytes with nitric oxide and prostaglandin E2.
- Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells.
- Neural precursor cell lines promote neurite branching.
- Maintaining and engineering neural stem cells for delivery of genetically encoded therapy to brain tumors.
- Neural stem cell delivery to the spinal cord in an ovine model of fetal surgery for spina bifida.
- Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease.
- Preparation of autogenic human feeder cells for growth of human embryonic stem cells.
- Genetic modification of neural stem cells.
- Brain tumor stem cells and the tumor microenvironmen.
- Stem cell-mediated regeneration of the intervertebral disc: cellular and molecular challenge.
- Neural stem cell transplantation in mouse brain.
- Quo vadis brain repair? A long axonal journey in the adult CNS.
- A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes.
- Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells.
- Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.
- Isolation of amniotic stem cell lines with potential for therapy.
- The leading edge of stem cell therapeutics.
- Neural stem cell transplant survival in brains of mice: assessing the effect of immunity and ischemia by using real-time bioluminescent imaging.
- Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins.
- Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells.
- Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology.
- Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets.
- Purkinje neuron degeneration in nervous (nr) mutant mice is mediated by a metabolic pathway involving excess tissue plasminogen activator.
- Human neurospheres derived from the fetal central nervous system are regionally and temporally specified but are not committed.
- Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-i...
- Acute injury directs the migration, proliferation, and differentiation of solid organ stem cells: evidence from the effect of hypoxia-ischemia in the CNS on clonal &qu...
- Special issue: the intersection of stem/progenitor cell biology and hypoxic-ischemic cerebral injury/stroke.
- Can science resolve the ethical impasse in stem cell research?
- Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents.
- Beyond fraud--stem-cell research continues.
- Exploring common ground in the stem cell ethical debate--a perspective for scientists: introduction to this special issue of stem cell reviews.
- A role for stem cell biology in the physiological and pathological aspects of aging.
- Expression profile of an operationally-defined neural stem cell clone.
- Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control me...
- Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway.
- Differentiation and tropic/trophic effects of exogenous neural precursors in the adult spinal cord.
- A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury.
- Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors.
- Neural stem/progenitor cells express costimulatory molecules that are differentially regulated by inflammatory and apoptotic stimuli.
- Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system.
- Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury.
- Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.
- Reality and immortality--neural stem cells for therapies.
- Constitutive EGFR signaling confers a motile phenotype to neural stem cells.
- Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis.
- Neural stem cell biology may be well suited for improving brain tumor therapies.
- Realistic prospects for stem cell therapeutics.
- The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue.
- Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons.
- Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury.
- Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat.
- Limitations in brain repair.
- Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus.
- Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells.
- Neural stem cells for CNS repair: state of the art and future directions.
- Generation, Expansion, and Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) Derived From the Umbilical Cords of Newborns.
- Implications and limitations of cellular reprogramming for psychiatric drug development.
- Laser-assisted generation of human induced pluripotent stem cells.
Schools
Perelman School of Medicine University of Pennsylvania
Boston Children39s Hospital
Children39s Hospital Boston
Harvard Longwood Program
Harvard Med School
Harvard Med School Joint Program
Procedures Preformed
- EEG (Electroencephalogram)
Conditions Treated
- Convulsions
- Epilepsy
Doctors Specialties
- Neonatal Medicine
- Neonat/Perinatology
Accepted Insurances
- Choice Plus POS II
- Blue Card PPO
- Advantage Preferred DirectAccess Plus PPO
- Blue Cross Blue Shield of California PPO
- Pathway X Direct Access PPO
- Pathway X Tiered Direct Access
- Cigna
- Covered California - Bronze PPO
- Employer Group HMO
- Health Net PPO
- Individual and Family PPO
- WholeCare Network HMO
- Medicaid
- Medicare MCR
- Molina
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- PacifiCare HMO
- United Healthcare
Awards
- Whos Who in Medicine and Healthcare
- Fellow (FAAP)
Education
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Boston Children's Hospital -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Rady Children's Hospital - San Diego
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