Professor, Internal Medicine, University of Iowa College of Medicine
Cardiology
Dr. Francis J. Miller Jr., MD
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Francis Miller works in the field of Cardiology. He studied medicine at University of Iowa Carver College of Medicine. University of Iowa Carver College of Medicine is ranked 29 in research and 16 in primary care medicine He received awards:"Nominated, Distinguished Mentor Award", "Nominated, Faculty Teacher of the Year for Internal Medicine Residents" and "Fellow". Francis Miller is also published. He has 74 publications published. The lastest publication: "Pharmacologic activation of the human coronary microcirculation in vitro: endothelium-dependent dilation and differential responses to acetylcholine.' Francis J. Miller Jr. accepts Medicare.
Publications
- Nox1 in cardiovascular Diseases: regulation and pathophysiology.
- Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout.
- Phosphorylation of Nox1 Regulates Association with NoxA1 Activation Domain.
- NOX2 protects against prolonged inflammation, lung injury, and mortality following systemic insults.
- NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells.
- Extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction.
- The multifunctional Ca(2)(+)/calmodulin-dependent kinase IIdelta (CaMKIIdelta) regulates arteriogenesis in a mouse model of flow-mediated remodeling.
- CaMKII is essential for the proasthmatic effects of oxidation.
- Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular Disease.
- Hydrogen Peroxide Promotes Aging-Related Platelet Hyperactivation and Thrombosis.
- Increased epidermal growth factor-like ligands are associated with elevated vascular nicotinamide adenine dinucleotide phosphate oxidase in a primate model of atherosc...
- Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection.
- Reactive oxygen species: from health to Disease.
- β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following Myocardial infarction.
- Increased Expression of Nox1 in Neointimal Smooth Muscle Cells Promotes Activation of Matrix Metalloproteinase-9.
- Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration.
- Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A.
- Statin therapy reduces growth of abdominal Aortic aneurysms.
- Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells.
- Role for Nox1 NADPH oxidase in atherosclerosis.
- Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.
- Was the role of statins in slowing the progression of abdominal Aortic aneurysms underestimated?
- Any questions? A concise guide to navigating the Q&A session after a presentation.
- A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation.
- An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor ac...
- Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production.
- A differential role for endocytosis in receptor-mediated activation of Nox1.
- Electrophysiology of reactive oxygen production in signaling endosomes.
- NADPH oxidase 4: walking the walk with Poldip2.
- Free radical scavenger specifically prevents ischemic focal ventricular tachycardia.
- Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury.
- Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy.
- Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone.
- Endothelial superoxide production is altered in sheep programmed by early gestation dexamethasone exposure.
- Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3.
- Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid...
- Deletion of p47phox attenuates angiotensin II-induced abdominal Aortic aneurysm formation in apolipoprotein E-deficient mice.
- Vitamin E inhibits abdominal Aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice.
- Early gestation dexamethasone programs enhanced postnatal ovine Coronary artery vascular reactivity.
- Regulation of endotoxin-induced proinflammatory activation in human Coronary artery cells: expression of functional membrane-bound CD14 by human Coronary artery smooth...
- The nitric oxide synthase inhibitor N(G)-nitro-L-arginine decreases deFibrillation-induced free radical generation.
- The nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) increases free radical generation and degrades left ventricular function after Myocardial ischemia-reperf...
- Reactive oxygen species mediate arachidonic acid-induced dilation in porcine Coronary microvessels.
- Gp91phox contributes to NADPH oxidase activity in Aortic fibroblasts but not smooth muscle cells.
- Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins.
- Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity.
- Aortic aneurysms: It's all about the stress.
- Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys.
- Functional evaluation of nonphagocytic NAD(P)H oxidases.
- The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.
- Oxidative stress in human abdominal Aortic aneurysms: a potential mediator of aneurysmal remodeling.
- Regression of atherosclerosis in monkeys reduces vascular superoxide levels.
- Using a peptide inhibitor of the glycoprotein IIb/IIIa platelet receptor: initial experience in patients with Acute peripheral arterial occlusions.
- Antioxidant therapy for atherosclerotic vascular Disease: the promise and the pitfalls.
- Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta.
- Nitric oxide synthase inhibitors decrease Coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model.
- H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury.
- Adventitial fibroblasts: backstage journeymen.
- AIF-1 in the activated smooth muscle cell : spectator or participant?
- Enhanced H(2)O(2)-induced cytotoxicity in "epithelioid" smooth muscle cells: implications for neointimal regression.
- Gene transfer of endothelial nitric oxide synthase improves relaxation of Carotid arteries from diabetic rabbits.
- Gene transfer of endothelial nitric oxide synthase reduces angiotensin II-induced endothelial dysfunction.
- Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells.
- Pharmacologic activation of the human Coronary microcirculation in vitro: endothelium-dependent dilation and differential responses to acetylcholine.
- Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis.
- Myogenic constriction of human Coronary arterioles.
- Percutaneous nephrostomy for nonoperative management of fungal urinary tract infections.
- Activation in the region of parabrachial nucleus elicits neurogenically mediated Coronary vasoconstriction.
- Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.
- The epidermal growth factor receptor and its ligands in cardiovascular Disease.
- Cell-Internalization SELEX: Method for Identifying Cell-Internalizing RNA Aptamers for Delivering siRNAs to Target Cells.
- Role of NADPH Oxidase and Xanthine Oxidase in Mediating Inducible VT/VF and Triggered Activity in a Canine Model of Myocardial Ischemia.
- Endothelial dysfunction in chronic inflammatory Diseases.
Schools
University of Ia Roy J amp L Carver Com
University Tex Sw Med Br
University Iowa Hospital Clins
Procedures Preformed
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
- Cardioverter-Defibrillator or Pacemaker Insertion, Removal or Repair
- Coronary Angioplasty, Atherectomy and Stent
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Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
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Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Nominated, Distinguished Mentor Award
- Nominated, Faculty Teacher of the Year for Internal Medicine Residents
- Fellow
Education
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University of Iowa Hospitals and Clinics -
University of Iowa Carver College of Medicine -
University of Iowa
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