Associate Professor, Obstetrics and Gynecology, Indiana University School of Medicine
Obstetrics & Gynecology
Dr. Frank Gonzalez, MD
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Frank Gonzalez is an expert in the field of Obstetrics & Gynecology. He studied medicine at Temple University School of Medicine. He received awards:"Indianapolis Top Doctors", "Excellence in Teaching Award", "Fellow (FACS)", "Fellow (FACOG)", "National Hispanic Fund Award", "New York State Board of Education Chancellor's Award" and "Whos Who in Medicine and Healthcare". Frank Gonzalez, MD is a published doctor and has 100 publications published. The lastest was: 'Mass Spectrometry-based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-induced Cancer.'
Publications
- Hyperandrogenism induces a proinflammatory TNFα response to glucose ingestion in a receptor-dependent fashion.
- Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women.
- Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adults.
- Obese reproductive-age women exhibit a proatherogenic inflammatory response during hyperglycemia.
- Mass Spectrometry-based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-induced Cancer.
- HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.
- Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota.
- Altered tumor necrosis factor alpha release from mononuclear cells of obese reproductive-age women during hyperglycemia.
- Establishing the Role of PPARβ/δ in Carcinogenesis.
- New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases.
- Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms.
- Hyperandrogenism exerts an anti-inflammatory effect in obese women with Polycystic ovary syndrome.
- Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women.
- Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in Polycystic ovary syndrome.
- New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production.
- Modulation of Colon Cancer by Nutmeg.
- Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity.
- Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation.
- Evidence of proatherogenic inflammation in Polycystic ovary syndrome.
- Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet.
- Pancreatic β-cell dysfunction in Polycystic ovary syndrome: Role of hyperglycemia-induced nuclear factor-κB activation and systemic inflammation.
- The accuracy of self-reported drug ingestion histories in emergency department patients.
- Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in Polycystic ovary syndrome.
- Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer.
- The altered mononuclear cell-derived cytokine response to glucose ingestion is not regulated by excess adiposity in Polycystic ovary syndrome.
- N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.
- Induction of Hyperandrogenism in Lean Reproductive-Age Women Stimulates Proatherogenic Inflammation.
- PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.
- Improved drug therapy: triangulating phenomics with genomics and metabolomics.
- Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling.
- Decreased visfatin after exercise training correlates with improved glucose tolerance.
- Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet.
- The nuclear receptor PPARβ/δ promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress.
- Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer.
- HIF/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin leading to hypoxia-induced inflammation.
- Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice.
- Evidence of mononuclear cell preactivation in the fasting state in Polycystic ovary syndrome.
- Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat.
- Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.
- Metabolic profiling of praziquantel enantiomers.
- Loss of von Hippel-Lindau protein (VHL) increases systemic cholesterol levels through targeting hypoxia-inducible factor 2α and regulation of bile acid homeostasis.
- Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo.
- LC-MS-based metabolomics: an update.
- Lipidomics Reveals a Link between CYP1B1 and SCD1 in Promoting Obesity.
- Modulation of Fatty Acid and Bile Acid Metabolism By Peroxisome Proliferator-Activated Receptor α Protects Against Alcoholic Liver Disease.
- Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice.
- Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in keratinocytes.
- Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and its Role in Polycyclic Aromatic Hydrocarbon-Induced Mitochondrial Dysfunction.
- In vivo application of the pure aryl hydrocarbon receptor antagonist GNF-351 is limited to the gastrointestinal track.
- Activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits human breast cancer cell line tumorigenicity.
- Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans.
- Glucose-Stimulated Oxidative Stress in Mononuclear Cells Is Related to Pancreatic β-Cell Dysfunction in Polycystic Ovary Syndrome.
- MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse.
- PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling.
- Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
- The Med1 Subunit of the Mediator Complex Induces Liver Cell Proliferation and Is Phosphorylated by AMP Kinase.
- Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.
- Identification of 2-Piperidone as a Biomarker of CYP2E1 Activity Through Metabolomic Phenotyping.
- Hepatic oxidative stress activates the Gadd45b gene via degradation of the transcriptional repressor STAT3.
- Quercetin inhibits radiation-induced skin fibrosis.
- Metabolomics reveals that tumor xenografts induce liver dysfunction.
- Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.
- Metabolomics Reveals Aging-associated Attenuation of Noninvasive Radiation Biomarkers in Mice: Potential Role of Polyamine Catabolism and Incoherent DNA Damage-repair.
- Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.
- Potential role of CYP2D6 in the central nervous system.
- Metabolomics: an essential tool to understand the function of peroxisome proliferator-activated receptor alpha.
- Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator-Activated Receptor alpha.
- PXR/CYP3A4-Humanized Mice for Studying Drug-Drug Interactions Involving Intestinal P-Glycoprotein.
- Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.
- Stable Isotope- and Mass Spectrometry-based Metabolomics as Tools in Drug Metabolism: A Study Expanding Tempol Pharmacology.
- Hypoxia-Inducible Factor-1alpha (HIF-1alpha) Potentiates beta-Cell Survival After Islet Transplantation of Human and Mouse Islets.
- Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity.
- Hypoxia-inducible Factor 1alpha Regulates a SOCS3-STAT3-Adiponectin Signal Transduction Pathway in Adipocytes.
- Protective role of vascular smooth muscle cell PPARgamma in angiotensin II-induced vascular disease.
- Adrenal dysfunction in Polycystic ovary syndrome: has it been lost to follow-up?
- Glucose ingestion stimulates atherothrombotic inflammation in Polycystic ovary syndrome.
- Analysis of the peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) cistrome reveals novel co-regulatory role of ATF4.
- A species difference in the peroxisome proliferator-activated receptor alpha-dependent response to the developmental effects of perfluorooctanoic acid.
- Cytochrome P450 regulation by alpha-tocopherol in Pxr-null and PXR-humanized mice.
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances CCl4-induced hepatotoxicity in an aryl hydrocarbon receptor-dependent manner.
- CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid.
- Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4ñ as a Disease Modifier.
- Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in Polycystic ovary syndrome.
- Implication of intestinal VDR deficiency in inflammatory bowel disease.
- Hyperglycemia-induced oxidative stress is independent of excess abdominal adiposity in normal-weight women with Polycystic ovary syndrome.
- Cytochrome P450 1B1 gene disruption minimizes deoxycorticosterone acetate-salt-induced hypertension and associated cardiac dysfunction and renal damage in mice.
- Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.
- Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator...
- TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury.
- Inflammation in response to glucose ingestion is independent of excess abdominal adiposity in normal-weight women with Polycystic ovary syndrome.
- Metabolic map and bioactivation of the anti-tumour drug noscapine.
- Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-beta.
- Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics.
- Novel metabolites and roles for alpha-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics.
- Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis.
- Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.
- Stromal adipocyte PPARgamma protects against breast tumorigenesis.
- Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis.
- Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice.
Schools
Temple University
Rochester Genl HospStrong
University Hosps Cleveland Case West
Procedures Preformed
- Gynecologic Cancer Screening
- Hysteroscopy
Conditions Treated
- Endometriosis
- Menstrual Disorders (incl. Dysmenorrhea)
- Ovarian Cysts
- Polycystic Ovarian Syndrome
- View All
Doctors Specialties
- Obstetrics
- Gynecology
Accepted Insurances
- Choice Plus POS II
- Pathway X Bronze Direct CACA IN HIX
- Anthem Blue Cross Blue Shield HMO
- Anthem Blue Cross Blue Shield PPO
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Bluegrass Family Health
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- Emblem Health
- First Health (Coventry Health Care) PPO
- HealthSmart
- Choice Care PPO
- Medical Mutual of Ohio
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Sagamore Plus
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- Indianapolis Top Doctors
- Excellence in Teaching Award
- Fellow (FACS)
- Fellow (FACOG)
- National Hispanic Fund Award
- New York State Board of Education Chancellor's Award
- Whos Who in Medicine and Healthcare
Education
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Case Western Reserve University - University Hospitals -
Temple University School of Medicine -
Harvard College
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