Physician
Infectious Disease
Dr. Frederick P. Heinzel, MD
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Frederick P. Heinzel, MD is an expert in the field of Infectious Disease. He researched medicine at University of California Irvine School of Medicine. University of California Irvine School of Medicine is ranked 45/62 in Research/PrimaryCare. Frederick Heinzel is also published. He has 56 publications published. The lastest publication: "Increased levels of soluble interleukin-4 receptor in the sera of patients with visceral leishmaniasis.'
Publications
- Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell funct...
- Accessory cell dependent NK cell mediated PBMC IFN-gamma production is defective in HIV infection.
- CpG-induced IFNgamma expands TLR4-specific IL-18 responses in vivo.
- In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN.
- Fms-like tyrosine kinase 3-based immunoprophylaxis against infection is improved by adjuvant treatment with anti-interleukin-10 antibody.
- Interleukin 12 and interferon-gamma synthetic deficiency is associated with dendritic cell cytopenia after cardiac surgery.
- Distinct phases in recovery of reconstituted innate cellular-mediated immunity after murine syngeneic bone marrow transplantation.
- Selective impairments in dendritic cell-associated function distinguish hepatitis C virus and HIV infection.
- Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-gamma synthesis.
- Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis.
- Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis.
- Immunoenhancement combined with amphotericin B as treatment for experimental visceral leishmaniasis.
- Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4.
- Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent.
- [IE and IgG antibodies against flavonoids following therapy with flavonoid-containing drugs].
- Recombinant IL-4 inhibits IL-6 synthesis by adherent peripheral blood cells in vitro.
- Deactivation of the innate cellular immune response following endotoxic and surgical injury.
- Pretreatment with recombinant Flt3 ligand partially protects against progressive cutaneous leishmaniasis in susceptible BALB/c mice.
- IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs.
- Interleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA4 antibody.
- Cure of progressive murine leishmaniasis: interleukin 4 dominance is abolished by transient CD4(+) T cell depletion and T helper cell type 1-selective cytokine therapy.
- Adjuvant-guided type-1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response.
- Endotoxin fails to induce IFN-gamma in endotoxin-tolerant mice: deficiencies in both IL-12 heterodimer production and IL-12 responsiveness.
- Increased levels of soluble interleukin-4 receptor in the sera of patients with visceral leishmaniasis.
- Increased capacity for interleukin-2 synthesis parallels disease progression in mice infected with Leishmania major.
- Underproduction of interleukin-12 in susceptible mice during progressive leishmaniasis is due to decreased CD40 activity.
- In vivo production and function of IL-12 p40 homodimers.
- IFN-gamma-independent production of IL-12 during murine endotoxemia.
- Immunoregulation of murine leishmaniasis by interleukin-12.
- IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.
- Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmani...
- Recombinant interleukin 12 cures mice infected with Leishmania major.
- Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon.
- IL-12 modulation of T helper responses to the filarial helminth, Brugia malayi.
- Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.
- Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells.
- Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo.
- Leishmania major: analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice.
- Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells.
- Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets.
- Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote.
- Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T ce...
- Infections in patients with humoral immunodeficiency.
- The role of IFN-gamma in the pathology of experimental endotoxemia.
- Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.
- Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.
- Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.
- Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection.
- Proteinase-resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity.
- Interleukin 12 and the regulation of CD4+ T-cell subset responses during murine Leishmaniasis.
- Filaria/Wolbachia activation of dendritic cells and development of Th1-associated responses is dependent on Toll-like receptor 2 in a mouse model of ocular onchocercia...
- CD40 and tumour necrosis factor-α co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages.
- T cells primed by Leishmania major infection cross-react with alloantigens and alter the course of allograft rejection.
- Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and toll-like receptor 4.
- Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation.
Schools
University of California At Irvine California College of Medicine amp Surgery
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
- Aetna
- Blue Cross Blue Shield
- Humana
- Medicaid
- Medicare MCR
- Tricare
- Neighborhood Health Partnership
- United Healthcare
Education
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University of Washington -
University of California Irvine School of Medicine
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