Professor, Pediatrics, Perelman School of Medicine
Pediatric Hematology & Oncology
Dr. Garrett M. Brodeur, MD
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Garrett M. Brodeur is an expert in the field of Pediatric Hematology & Oncology. He went to Washington University School of Medicine in St. Louis. He has 3 awards "Pediatric Oncologist Award", "Elected Member" and "Fellow". Garrett Brodeur is a published doctor and has 35 publications published. The lastest was: 'Role of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas.'
Publications
- Identification of patient subgroups with markedly disparate rates of MYCN amplification in neuroblastoma: A report from the International Neuroblastoma Risk Group proj...
- Role of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas.
- Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy.
- Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma.
- TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts.
- Mechanisms of neuroblastoma regression.
- Mutations in NTRK3 Suggest a Novel Signaling Pathway in Human Congenital Heart Disease.
- Role of CHD5 in Human Cancers: 10 Years Later.
- Rotary bioreactor culture can discern specific behavior phenotypes in Trk-null and Trk-expressing neuroblastoma cell lines.
- Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal Cancer stages.
- Therapeutic targets for neuroblastomas.
- CHD5 is required for spermiogenesis and chromatin condensation.
- Network-based analysis of multivariate gene expression data.
- Clinical significance of NTRK family gene expression in neuroblastomas.
- Knowing Your ABCCs: Novel Functions of ABCC Transporters.
- Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma.
- Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study.
- Getting into the AKT.
- Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma.
- Trk receptor expression and inhibition in neuroblastomas.
- The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report.
- CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas.
- A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene.
- Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group.
- Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number.
- Outcomes of children with intermediate-risk neuroblastoma after treatment stratified by MYCN status and tumor cell ploidy.
- Proliferation of human neuroblastomas mediated by the epidermal growth factor receptor.
- Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study.
- Resistance to chemotherapy mediated by TrkB in neuroblastomas.
- Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13.
- No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3.
- Commentary on Kaneko et al.: Intensified chemotherapy increases the survival rates in patients with stage 4 neuroblastoma with MYCN amplification.
- Expression of the neurotrophin receptor TrkA down-regulates expression and function of angiogenic stimulators in SH-SY5Y neuroblastoma cells.
- Significance of intratumoral genetic heterogeneity in neuroblastomas.
Schools
Washington Center School of Medicine
Chldns Hospital
St Jude Chldns Rsch Hospital
Conditions Treated
- Adrenal Gland Cancer
- Anemia
- Deep Vein Thrombosis (DVT)
- ENT Cancer
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Pediatric Oncologist Award
- Elected Member
- Fellow
Education
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Washington University School of Medicine in St. Louis
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