Professor of Medicine, Joslin Diabetes Center
Endocrinology
Dr. George L. King, MD
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George King practices Endocrinology. He graduated from Duke University School of Medicine. Duke University School of Medicine is a top medical university. Duke University School of Medicine is ranked 8 in research and 29 in primary care medicine He received 1 awards: "Elected Member". Dr. George L. King is a published doctor as well. He has 80 publications published. The latest was: PKC beta activation inhibits interleukin-18 binding protein causing endothelial dysfunction and diabetic atherosclerosis.
Publications
- PKC beta activation inhibits interleukin-18 binding protein causing endothelial dysfunction and diabetic atherosclerosis.
- Obesity-associated Gingival Vascular Inflammation and Insulin Resistance.
- Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C-β Isoform in the End...
- Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells.
- Vascular complications of Diabetes: mechanisms of injury and protective factors.
- Protective Effects of GLP-1 on Glomerular Endothelium and Its Inhibition by PKCβ Activation in Diabetes.
- Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy.
- Inhibition of insulin signaling in endothelial cells by protein kinase C induced phosphorylation of P85 subunit of PI3-kinase.
- Response to Comment on: Sun et al. Protection From Retinopathy and Other Complications in Patients With Type 1 Diabetes of Extreme Duration: The Joslin 50-Year Medalis...
- PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.
- A complex interplay of factors causes diabetic nephropathy.
- Protection from retinopathy and other complications in patients with type 1 Diabetes of extreme duration: the joslin 50-year medalist study.
- Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of Diabetes and obesity.
- Endothelium-dependent delivery of insulin to muscle interstitium.
- A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 Diabetes.
- Residual insulin production and pancreatic ß-cell turnover after 50 years of Diabetes: Joslin Medalist Study.
- Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice.
- Activation of protein kinase C isoforms and its impact on diabetic complications.
- Kidney complications: factors that protect the diabetic vasculature.
- Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
- Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
- Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.
- Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.
- The role of inflammatory cytokines in Diabetes and its complications.
- Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells.
- More sugar, less blood vessels: another piece in the puzzle of increased cardiovascular risk in Diabetes.
- Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.
- Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells.
- Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study.
- Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in Diabetes.
- Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.
- Summary statement IV: Obesity and Diabetes: opportunities for translation of basic research.
- Reduction of Diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.
- Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects.
- Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight ...
- Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and i...
- Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance.
- Identification of linguistic barriers to Diabetes knowledge and glycemic control in Chinese Americans with Diabetes.
- Can protein kinase C beta-selective inhibitor, ruboxistaurin, stop vascular complications in diabetic patients?
- Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.
- Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium.
- Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications.
- Proatherosclerotic mechanisms involving protein kinase C in Diabetes and insulin resistance.
- Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.
- The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in Type 1 and Type 2 diabetic patients.
- Oxidative stress and antioxidant treatment in Diabetes.
- Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 Diabetes.
- Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein.
- Protein kinase Cbeta isoform inhibitors: a new treatment for diabetic cardiovascular diseases.
- Microvascular complications of Diabetes.
- Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis.
- Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications.
- Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.
- The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.
- Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes.
- Characterization of retinal leukostasis and hemodynamics in insulin resistance and Diabetes: role of oxidants and protein kinase-C activation.
- Applications of inhibitors for protein kinase C and their isoforms.
- Molecular understanding of hyperglycemia's adverse effects for diabetic complications.
- Expression of connective tissue growth factor is increased in injured myocardium associated with protein kinase C beta2 activation and Diabetes.
- Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy.
- Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells.
- Differential effects of bactericidal/permeability-increasing protein (BPI) analogues on retinal neovascularization and retinal pericyte growth.
- Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired coll...
- Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proli...
- Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-i...
- Diabetes Mellitus and its Complications in Asian Americans.
- Improvement of insulin sensitivity by isoenergy high carbohydrate traditional asian diet: a randomized controlled pilot feasibility study.
- Mechanisms of Disease: endothelial dysfunction in insulin resistance and Diabetes.
- New perspectives on diabetic vascular complications: the loss of endogenous protective factors induced by hyperglycemia.
- Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice.
- Diabetes: Podocytes lose their footing.
- Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.
- The role of protein kinase C activation and the vascular complications of Diabetes.
- Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin.
- Hyperglycemia-induced oxidative stress in diabetic complications.
- Molecular targets of diabetic cardiovascular complications.
- Retinopathy in Diabetes.
- B-cell signaling: protein kinase Cdelta puts the brakes on.
- Characterization of factors affecting attainment of glycemic control in asian americans with Diabetes in a culturally specific program.
Schools
Duke University School Of Medicine
University Wash Hospital
National Institute Of Health
Conditions Treated
- Diabetes Type 1
- Diabetes Type 2
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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University of Washington -
Duke University Hospital -
Duke University School of Medicine
Hospital
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Beth Israel Deaconess Medical Center
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