Physician
Urology
Dr. George L. Stark, MD
George Stark works in the field of Urology. He researched medicine at University of Colorado Denver School of Medicine. University of Colorado Denver School of Medicine is a top medical university. University of Colorado Denver School of Medicine is ranked 35 in research and 8 in primary care medicine He received 2 awards: "Elected Member" and "Fellow (FACS)". George Stark has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Photofrin II sensitized modifications of ion transport across the plasma membrane of an epithelial cell line: I. Electrical measurements at the whole-cell level.'
Publications
- Pharmacological targeting of the histone chaperone complex FACT preferentially eliminates glioblastoma stem cells and prolongs survival in preclinical models.
- Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness.
- Quinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, NF-κB, and Cell-Cycle Progression in Non-Small Cell Lung Cancer.
- Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB-mediated mechanism.
- IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage.
- Role of lysine methylation of NF-κB in differential gene regulation.
- PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB.
- Using Sequential Immunoprecipitation and Mass Spectrometry to Identify Methylation of NF-κB.
- Vascular endothelial growth factor expression in patients suffering from thrombangitis obliterans.
- Coinheritance of factor V Leiden (F5 1691A) and prothrombin 20210 A (F2 20210A) in an Austrian family as cause for early onset of venous thromboembolism.
- [Simultaneous radiochemotherapy of locally advanced stage T4 breast cancer].
- Photodynamic inactivation of the Na,K-ATPase occurs via different pathways.
- Photofrin II sensitized modifications of ion transport across the plasma membrane of an epithelial cell line: I. Electrical measurements at the whole-cell level.
- An update on chronic myeloid leukaemia.
- Preparation, characterization, and use of an antiserum specific for 2',5'-oligoadenylates.
- An improved method for purifying 2',5'-oligoadenylate synthetases.
- Charomids: cosmid vectors for efficient cloning and mapping of large or small restriction fragments.
- Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure.
- Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.
- Nd:YAG laser with sapphire tip combined with balloon angioplasty in peripheral arterial occlusions. Long-term results.
- Interferon pretreatment inhibits simian virus 40 infections by blocking the onset of early transcription.
- DNA amplification in drug resistant cells and in tumours.
- Comparison of acute effects of anthracyclines on cardiac electrophysiological parameters of isolated guinea-pig hearts.
- Glucocorticoids regulate the expression of the stressprotein alpha B-crystallin.
- Induction of human mRNAs by interferon.
- Viral proteins and RNAs in BHK cells persistently infected by lymphocytic choriomeningitis virus.
- Persistent infection of some standard cell lines by lymphocytic choriomeningitis virus: transmission of infection by an intracellular agent.
- Separation and properties of two kinds of simian virus 40 late transcription complexes.
- Effects of genome position and the DNA damage checkpoint on the structure and frequency of sod2 gene amplification in fission yeast.
- Design and use of potent, specific enzyme inhibitors.
- Excess antisense RNA from infectious recombinant SV40 fails to inhibit expression of a transfected, interferon-inducible gene.
- The control of interferon-inducible gene expression.
- Abundant nuclear ribonucleoprotein form of CAD RNA.
- Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells.
- Molecular analysis of a human interferon-inducible gene family.
- Interferon response element of the human gene 6-16.
- Defective keratocyte apoptosis in response to epithelial injury in stat 1 null mice.
- Structure of DNA formed in the first step of CAD gene amplification.
- Hamster cells with increased rates of DNA amplification, a new phenotype.
- Regulation and mechanisms of mammalian gene amplification.
- A strategy for quickly identifying all unique two-hybrid or library plasmids within a pool of yeast transformants.
- Regulation and mechanisms of gene amplification.
- Mechanisms of sod2 gene amplification in Schizosaccharomyces pombe.
- Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.
- Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription.
- A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells.
- Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons.
- T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis.
- Specific association of simian virus 40 tumor antigen with simian virus 40 chromatin.
- Transcription factors induced by interferons alpha and gamma.
- Two deletions within genes for simian virus 40 structural proteins VP2 and VP3 lead to formation of abnormal transcriptional complexes.
- Coordinate overproduction of orotate phosphoribosyltransferase and orotidine-5''-phosphate decarboxylase in hamster cells resistant to pyrazofurin and 6-azauridine.
- Regulation of carbamoyl phosphate synthetase-aspartate transcarbamoylase-dihydroorotase gene expression in growing and arrested cells.
- DNA amplification is rare in normal human cells.
- Preferential amplification of rearranged sequences near amplified adenylate deaminase genes.
- High frequency of double drug resistance in the B16 melanoma cell line.
- Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells.
- Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.
- N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthe...
- Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells.
- Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells.
- alpha-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences.
- The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression.
- Properties of dispersed, highly repeated DNA within and near the hamster CAD gene.
- Interferon-dependent signaling pathways: DNA elements, transcription factors, mutations, and effects of viral proteins.
- Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.
- Construction of a cDNA to the hamster CAD gene and its application toward defining the domain for aspartate transcarbamylase.
- Differential response of the human 6-16 and 9-27 genes to alpha and gamma interferons.
- Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes.
- Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.
- Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.
- Deficient T cell fate specification in mice with an induced inactivation of Notch1.
- Expression of the terminal protein of hepatitis B virus is associated with failure to respond to interferon therapy.
- Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles.
- Evolution and stability of chromosomal DNA coamplified with the CAD gene.
- General method for cloning amplified DNA by differential screening with genomic probes.
- Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.
- Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.
- A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
- Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
- Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway.
- Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes.
- Induction of gene amplification by 5-aza-2''-deoxycytidine.
- Association of STATs with relatives and friends.
- Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo.
- Simian virus 40-infected, interferon-treated cells contain 2',5'-oligoadenylates which do not activate cleavage of RNA.
- A single DNA response element can confer inducibility by both alpha- and gamma-interferons.
- Tumor necrosis factor-alpha affects LTR-controlled oncogene expression in transformed mouse fibroblasts at the post-transcriptional level.
- Regulation of simian virus 40 transcription: sensitive analysis of the RNA species present early in infections by virus or viral DNA.
- High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.
- Mutant human cells defective in induction of major histocompatibility complex class II genes by interferon gamma.
- Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.
- Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (...
- Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction.
- Interferon-induced gene expression in wild-type and interferon-resistant human lymphoblastoid (Daudi) cells.
- Molecular cloning of a gene selectively induced by gamma interferon from human macrophage cell line U937.
- The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors.
- Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene.
- Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.
- Simian virus 40 large tumor antigen alone or two cooperating oncogenes convert REF52 cells to a state permissive for gene amplification.
Schools
Univ Of Co Sch Of Med
University Nm
Doctors Specialties
- Urology
Accepted Insurances
Awards
- Elected Member
- Fellow (FACS)
Education
-
University of New Mexico -
University of Colorado Denver School of Medicine
Hospital
-
Cleveland Clinic
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