Physician
Psychiatry
Dr. Georgette F. Somjen, MD
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Georgette F. Somjen is an expert in the field of Psychiatry. He graduated from University of North Carolina at Chapel Hill School of Medicine. University of North Carolina at Chapel Hill School of Medicine is a top medical college. University of North Carolina at Chapel Hill School of Medicine has a rank of 22 in research and a 2 in primary care Dr. Georgette F. Somjen is also a published physician. He has 101 paper published. The most recent paper is: Inhibition of major cationic inward currents prevents spreading depression-like hypoxic depolarization in rat hippocampal tissue slices. He accepts Medicare payments and is listed with Medicare.gov.
Publications
- Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation.
- The effects of convulsant doses of penicillin on primary afferents, dorsal root ganglion cells, and on ''presynaptic'' inhibition in the spinal cord.
- Influence of potassium and neuroglia in the generation of seizures and their treatment.
- Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse.
- Glutamine can enhance synaptic transmission in hippocampal slices.
- Oxidative metabolism, extracellular potassium and sustained potential shifts in cat spinal cord in situ.
- Stimulus-evoked and seizure-related responses of extracellular calcium activity in spinal cord compared to those in cerebral cortex.
- Seizure-like afterdischarges simulated in a model neuron.
- Neuron-glia interactions.
- Extracellular potassium in the mammalian central nervous system.
- Channel shutdown: a response of hippocampal neurons to adverse environments.
- Extracellular calcium and action potentials of soma and dendrites of hippocampal pyramidal cells.
- Nervenkitt: notes on the history of the concept of neuroglia.
- Changes in extracellular calcium and magnesium and synaptic transmission in isolated mouse spinal cord.
- Spontaneous activity induced in isolated mouse spinal cord by high extracellular calcium and by low extracellular magnesium.
- Pathophysiology of the spinal cord studied in vitro.
- Spinal dorsal horn neurons in elevated extracellular calcium: cell properties and spontaneous discharges.
- Reversible effects of hypoxia on neurons in mouse dorsal root ganglia in vitro.
- Postischemic synaptic physiology of CA1 hippocampal pyramidal cells.
- Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils.
- Report of the worldwide survey on teaching physiology.
- Effects of strongly anisosmotic and NaCl deficient solutions on muscimol- and glutamate evoked whole-cell currents in freshly dissociated hippocampal neurons.
- Calcium dependence of synaptic transmission in the hippocampal slice.
- Aristides Leão's discovery of cortical spreading depression.
- Spreading depression of Leão: 50 years since a seminal discovery.
- The effect of depressing glial function in rat brain in situ on ion homeostasis, synaptic transmission, and neuron survival.
- The effect of graded hypoxia on the hippocampal slice: an in vitro model of the ischemic penumbra.
- Role of neuronal synchronizing mechanisms in the propagation of spreading depression in the in vivo hippocampus.
- Chlorpromazine protects brain tissue in hypoxia by delaying spreading depression-mediated calcium influx.
- Hyperexcitability following moderate hypoxia in hippocampal tissue slices.
- The effects of temperature on synaptic transmission in hippocampal tissue slices.
- Current source density of sustained potential shifts associated with electrographic seizures and with spreading depression in rat hippocampus.
- Acidification of interstitial fluid in hippocampal formation caused by seizures and by spreading depression.
- Potassium and calcium concentrations in interstitial fluid of hippocampal formation during paroxysmal responses.
- Effects of transient forebrain ischemia in area CA1 of the gerbil hippocampus: an in vitro study.
- Osmotic-hypertensive opening of the blood-brain barrier in rats does not necessarily provide access for potassium to cerebral interstitial fluid.
- The effect of changing extracellular potassium concentration on synaptic transmission in isolated spinal cords.
- Hypoxic failure of synaptic transmission in the isolated spinal cord, and the effects of divalent cations.
- Pathophysiology of pH and Ca2+ in bloodstream and brain.
- Computer simulations of neuron-glia interactions mediated by ion flux.
- Interstitial ion concentrations and paroxysmal discharges in hippocampal formation and spinal cord.
- Interstitial potassium concentration, slow depolarization and focal potential responses in the dorsal horn of the rat spinal slice.
- Low external NaCl concentration and low osmolarity enhance voltage-gated Ca currents but depress K currents in freshly isolated rat hippocampal neurons.
- Postischemic synaptic physiology in area CA1 of the gerbil hippocampus studied in vitro.
- Enhancement of persistent sodium current by internal fluorescence in isolated hippocampal neurons.
- Effects of extracellular pH on voltage-gated Na+, K+ and Ca2+ currents in isolated rat CA1 neurons.
- Effects of prolonged elevation of potassium on hippocampus of anesthetized rats.
- An NMDA-mediated component of excitatory synaptic input to dentate granule cells in ''epileptic'' human hippocampus studied in vitro.
- Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations.
- Conditions for the triggering of spreading depression studied with computer simulations.
- Two mechanisms that raise free intracellular calcium in rat hippocampal neurons during hypoosmotic and low NaCl treatment.
- Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat.
- Suppression of presynaptic calcium currents by hypoxia in hippocampal tissue slices.
- Prolonged exposure to high potassium concentration results in irreversible loss of synaptic transmission in hippocampal tissue slices.
- The ionic and metabolic responses associated with neuronal depression of Leão's type in cerebral cortex and in hippocampal formation.
- Sustained potential shifts and paroxysmal discharges in hippocampal formation.
- The sources of extracellular potassium accumulation in the CA1 region of hippocampal slices.
- Analysis of potential shifts associated with recurrent spreading depression and prolonged unstable spreading depression induced by microdialysis of elevated K+ in hipp...
- The effects of moderate changes of extracellular K+ and Ca2+ on synaptic and neural function in the CA1 region of the hippocampal slice.
- Differential sensitivity to intracellular pH among high- and low-threshold Ca2+ currents in isolated rat CA1 neurons.
- Propagation of spreading depression among dendrites and somata of the same cell population.
- Calcium sensitive non-selective cation current promotes seizure-like discharges and spreading depression in a model neuron.
- Mechanisms of spreading depression and hypoxic spreading depression-like depolarization.
- NMDA antagonists: lack of protective effect against hypoxic damage in CA1 region of hippocampal slices.
- Membrane currents in CA1 pyramidal cells during spreading depression (SD) and SD-like hypoxic depolarization.
- The effect of graded hypertonia on interstitial volume, tissue resistance and synaptic transmission in rat hippocampal tissue slices.
- Potassium-induced enhancement of persistent inward current in hippocampal neurons in isolation and in tissue slices.
- Effects of hypertonia on voltage-gated ion currents in freshly isolated hippocampal neurons, and on synaptic currents in neurons in hippocampal slices.
- Calcium, magnesium, and long-term recovery from hypoxia in hippocampal tissue slices.
- Extracellular ions, hypoxic irreversible loss of function and delayed postischemic neuron degeneration studied in vitro.
- Cellular physiology of hypoxia of the mammalian central nervous system.
- Mechanism of spreading depression: a review of recent findings and a hypothesis.
- Correlation between function and structure in "epileptic" human hippocampal tissue maintained in vitro.
- Inhibition of major cationic inward currents prevents spreading depression-like hypoxic depolarization in rat hippocampal tissue slices.
- Volume changes induced by osmotic stress in freshly isolated rat hippocampal neurons.
- Lasting neuron depression induced by high potassium and its prevention by low calcium and NMDA receptor blockade.
- Enhancement of whole cell synaptic currents by low osmolarity and by low [NaCl] in rat hippocampal slices.
- Na(+) and K(+) concentrations, extra- and intracellular voltages, and the effect of TTX in hypoxic rat hippocampal slices.
- Spreading depression-like depolarization and selective vulnerability of neurons. A brief review.
- Heptanol but not fluoroacetate prevents the propagation of spreading depression in rat hippocampal slices.
- Na(+) dependence and the role of glutamate receptors and Na(+) channels in ion fluxes during hypoxia of rat hippocampal slices.
- Optical mapping of translucence changes in rat hippocampal slices during hypoxia.
- Spreading depression-like hypoxic depolarization in CA1 and fascia dentata of hippocampal slices: relationship to selective vulnerability.
- Ion channel involvement in hypoxia-induced spreading depression in hippocampal slices.
- Whole-cell membrane current and membrane resistance during hypoxic spreading depression.
- Hypotonic exposure enhances synaptic transmission and triggers spreading depression in rat hippocampal tissue slices.
- The extent and mechanism of the loss of function caused by strongly hypotonic solutions in rat hippocampal slices.
- Interstitial space, electrical resistance and ion concentrations during hypotonia of rat hippocampal slices.
- Role of calcium channels in spreading depression in rat hippocampal slices.
- Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically.
- Intrinsic optical signals in rat hippocampal slices during hypoxia-induced spreading depression-like depolarization.
- Use of intrinsic optical signals to monitor physiological changes in brain tissue slices.
- Hypertonic environment prevents depolarization and improves functional recovery from hypoxia in hippocampal slices.
- Interstitial volume changes during spreading depression (SD) and SD-like hypoxic depolarization in hippocampal tissue slices.
- Mitochondrial and intrinsic optical signals imaged during hypoxia and spreading depression in rat hippocampal slices.
- Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utiliz...
- Differences in O2 availability resolve the apparent discrepancies in metabolic intrinsic optical signals in vivo and in vitro.
- Is spreading depression bad for you? Focus on "repetitive normoxic spreading depression-like events result in cell damage in juvenile hippocampal slice cultures".
- Ion regulation in the brain: implications for pathophysiology.
- Two different mechanisms underlie reversible, intrinsic optical signals in rat hippocampal slices.
Schools
University of North Carolina At Chapel Hill
Doctors Specialties
- Family Medicine
- Psychiatry
Accepted Insurances
- Blue Card PPO
- Great West Healthcare-Cigna PPO
- Commercial Insurance Company
- Medicare Advantage PFFS
- Choice Care PPO
- Medicare MCR
- United Healthcare
Education
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Case Western Reserve University - University Hospitals -
Wake Forest University -
University of North Carolina at Chapel Hill School of Medicine
Drug Facts
| NPI NUMBER | 1821004078 | |
| NPPES Provider LastName | SOMJEN | |
| NPPES Provider FirstName | GEORGETTE | |
| NPPES Provider ZIPCode | 700016717 | |
| NPPES Provider State | LA | |
| Specialty Description | Addiction Medicine | |
| Total Claim Count | 2188.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1821004078 |
| Last Name Of The Provider | SOMJEN |
| First Name Of The Provider | GEORGETTE |
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