Professor of Medicine, Joslin Diabetes Center
Endocrinology
Dr. Gordon C. Weir, MD
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Gordon Weir works in the field of Endocrinology. He graduated from Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He has 3 awards "CMS Meaningful Use Stage 1 Certification", "Diabetes Recognition Program" and "Elected Member". Gordon Weir is a published doctor and has 105 publications published. The lastest was: 'Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus.'
Publications
- Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice.
- Reduced Ki67 staining in the postmortem state calls into question past conclusions about the lack of turnover of adult human beta cells.
- Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.
- Repurposing cAMP-Modulating Medications to Promote β-Cell Replication.
- Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies.
- β-cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment.
- β-cell dedifferentiation in Diabetes is important, but what is it?
- PDX1 in Ducts Is Not Required for Postnatal Formation of β-Cells but Is Necessary for Their Subsequent Maturation.
- Pancreatic duct ligation after almost complete beta-cell loss: Exocrine regeneration but no evidence of beta-cell regeneration.
- Genetic Disruption of SOD1 Gene Causes Glucose Intolerance and Impairs β-cell Function.
- Making β Cells from Adult Cells Within the Pancreas.
- Enhanced function of immuno-isolated islets in Diabetes therapy by co-encapsulation with an anti-inflammatory drug.
- Islet encapsulation: advances and obstacles.
- Islet ? cell mass in Diabetes and how it relates to function, birth, and death.
- Thyroid Hormone Promotes Postnatal Rat Pancreatic ?-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA.
- Core-Shell Hydrogel Microcapsules for Improved Islets Encapsulation.
- Cellular transplantation into lymph nodes may not be such a crazy idea.
- Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.
- Subpopulations of GFP-Marked Mouse Pancreatic β-Cells Differ in Size, Granularity, and Insulin Secretion.
- Concise review: pancreas regeneration: recent advances and perspectives.
- Stem cell approaches for Diabetes: towards beta cell replacement.
- Islets Transplanted in Immunoisolation Devices: A Review of the Progress and the Challenges that Remain.
- Finally! A human pancreatic ? cell line.
- Sleeping Islets and the Relationship Between {beta}-Cell Mass and Function.
- Quantitative assessment of islets of langerhans encapsulated in alginate.
- Quantitative analysis of cell composition and purity of human pancreatic islet preparations.
- Enumeration of islets by nuclei counting and light microscopic analysis.
- Beta-cell growth and regeneration: replication is only part of the story.
- Dreams for type 1 Diabetes: shutting off autoimmunity and stimulating beta-cell regeneration.
- Current status of islet cell replacement and regeneration therapy.
- Protective unfolded protein response in human pancreatic beta cells transplanted into mice.
- Ductal origin hypothesis of pancreatic regeneration under attack.
- Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 Diabetes.
- Lack of evidence for recipient precursor cells replenishing β-cells in transplanted islets.
- Control of inflammation with alpha1-antitrypsin: a potential treatment for islet transplantation and new-onset type 1 Diabetes.
- Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.
- Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.
- An appreciation of Robert Turner.
- Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 Diabetes and regulation of IL-1beta in human islets by...
- A model for diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse.
- Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.
- A stirred microchamber for oxygen consumption rate measurements with pancreatic islets.
- Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation.
- Differentiation of affinity-purified human pancreatic duct cells to beta-cells.
- Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in Diabetes.
- Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.
- A dominant role for glucose in beta cell compensation of insulin resistance.
- Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets.
- The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.
- Establishment of a diabetic mouse model with progressive diabetic nephropathy.
- New sources of pancreatic beta-cells.
- The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
- Islet transplantation: progress and challenge.
- Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formati...
- Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells.
- Long-term normoglycemia in rats receiving transplants with encapsulated islets.
- Five stages of evolving beta-cell dysfunction during progression to Diabetes.
- Beta-cell precursors--a work in progress.
- Exercise induces hypoglycemia in rats with islet transplantation.
- Importance of hyperglycemia on the primary function of allogeneic islet transplants.
- PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.
- Induction of Mad expression leads to augmentation of insulin gene transcription.
- Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated Diabetes.
- Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice.
- Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression.
- Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and Diabetes.
- Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation.
- Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.
- Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.
- Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells.
- Islet transplantation under the kidney capsule corrects the defects in glycogen metabolism in both liver and muscle of streptozocin-diabetic rats.
- Intra-islet insulin-glucagon-somatostatin relationships.
- Pancreatic islets of variable size--insulin secretion and glucose utilization.
- Glucose utilization in islets of hyperglycemic rat models with impaired glucose-induced insulin secretion.
- The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment.
- Sustained oscillations of insulin, glucagon, and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration.
- Clonal analysis of insulin and somatostatin secretion and L-dopa decarboxylase expression by a rat islet cell tumor.
- Glucagon-like peptide-1 (GLP-1): a piece of the incretin puzzle.
- Unresponsiveness to glucose in a streptozocin model of Diabetes. Inappropriate insulin and glucagon responses to a reduction of glucose concentration.
- Somatostatin neutralization stimulates glucagon and insulin secretion from the avian pancreas.
- Impaired insulin secretion associated with near normoglycemia. Study in normal rats with 96-h in vivo glucose infusions.
- Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions.
- Glucagon secretion from the perfused rat pancreas. Studies with glucose and catecholamines.
- Somatostatin and pancreatic polypeptide secretion: effects of glucagon, insulin, and arginine.
- Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulat...
- Pancreatic islet cell toxicity of amylin associated with type-2 Diabetes mellitus.
- Acetylcholine stimulates insulin, glucagon, and somatostatin release in the perfused chicken pancreas.
- Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.
- Glucagon secretion from the perfused pancreas of streptozotocin-treated rats.
- [Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis.
- Hormone release by islet B cell-enriched and A and D cell-enriched populations prepared by flow cytometry.
- Nucleotide and nucleoside stimulation of glucagon secretion.
- Somatostatin inhibition of epinephrine-induced glucagon secretion.
- Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.
- p38 MAPK is a major regulator of MafA protein stability under oxidative stress.
- High-density culture of human islets on top of silicone rubber membranes.
- Pancreatic somatostatin.
- Limited B cell regeneration in a B cell deficient rat model: studies with dexamethasone.
- Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas.
- Nerve growth factor and pancreatic APUD cells.
- The Hypoglycemic PhenoType is Islet Cell-Autonomous in Short-chain Hydroxyacyl-CoA Dehydrogenase (SCHAD) Deficient Mice.
- Dynamic development of the pancreas from birth to adulthood.
- Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement.
- Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes.
Schools
Harvard Medical School
University Hosps
Massachusetts General Hospital
Conditions Treated
- Diabetes Type 1
- Hyperlipidemia
Doctors Specialties
- Endocrinology
Accepted Insurances
- Cigna
- Commercial Insurance Company
- Fallon Community Health Plan
- Medicare MCR
- Neighborhood Health Plan
Awards
- CMS Meaningful Use Stage 1 Certification
- Diabetes Recognition Program
- Elected Member
Education
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Massachusetts General Hospital -
Case Western Reserve University - University Hospitals -
Harvard Medical School
Hospital
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Beth Israel Deaconess Medical Center
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