Professor, Psychiatry, UCLA School of Medicine
Neurology
Dr. Harley I. Kornblum, MD
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Doctor Harley I. Kornblum, MD works in the field of Neurology. He graduated from University of California Irvine School of Medicine. University of California Irvine School of Medicine is ranked 45/62 in Research/PrimaryCare. He has 2 awards "CMS Meaningful Use Stage 1 Certification" and "Super Doctor". Doctor Harley I. Kornblum, MD is also a published MD. He has 101 publication published. The most recent publication is: Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy.
Publications
- Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells.
- Neuronal ceroid lipofuscinosis genes, CLN2, CLN3 and CLN5 are spatially and temporally co-expressed in a developing mouse brain.
- Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation.
- Maternal Embryonic Leucine Zipper Kinase: Key Kinase for Stem Cell Phenotype in Glioma and Other Cancers.
- Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone.
- Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.
- MELK-dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells.
- Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas.
- Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy.
- Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells.
- A molecular screening approach to identify and characterize inhibitors of glioblastoma multiforme stem cells.
- Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.
- Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.
- CD44v6 Regulates Growth of Brain Tumor Stem Cells Partially through the AKT-Mediated Pathway.
- MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.
- Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation.
- Hydrogel matrix to support stem cell survival after brain transplantation in stroke.
- A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens.
- A multipronged approach to the identification and study of an important oncogene in GBM.
- Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors.
- Endogenous Wnt signaling maintains neural progenitor cell potency.
- Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.
- Neurosphere formation is an independent predictor of clinical outcome in malignant glioma.
- Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.
- Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells.
- Methods for analysis of brain tumor stem cell and neural stem cell self-renewal.
- Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice.
- Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells.
- BMPing off glioma stem cells.
- Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation.
- Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006.
- Introduction to neural stem cells.
- Detection of a microRNA signal in an in vivo expression set of mRNAs.
- Brain tumor stem cells.
- Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non...
- Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion.
- PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.
- Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.
- Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions.
- Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily.
- Evolution of diaschisis in a focal stroke model.
- Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in proge...
- Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
- Cancerous stem cells can arise from pediatric brain tumors.
- Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks.
- Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain.
- The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP.
- The RAS effector RIN1 modulates the formation of aversive memories.
- Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNA.
- Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition.
- Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis again...
- Roles of insulin and transferrin in neural progenitor survival and proliferation.
- Measures of psychopathology in children with complex partial seizures and primary generalized Epilepsy with absence.
- Global brain dysfunction in an infant with pyridoxine dependency: evaluation with EEG, evoked potentials, MRI, and PET.
- Social communication in children with Epilepsy.
- The use of representational difference analysis and cDNA microarrays in neural repair research.
- Molecular markers in CNS stem cell research: hitting a moving target.
- Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
- Cerebral hemidecortication alters expression of transforming growth factor alpha mRNA in the neostriatum of developing rats.
- Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA.
- Expression of EGF receptor mRNA in rat nigrostriatal system.
- Effects of morphine on DNA synthesis in neonatal rat brain.
- Trophic stimulation of cultured neurons from neonatal rat brain by epidermal growth factor.
- Postnatal development of opioid systems in rat brain.
- Postnatal development of multiple opioid receptors in rat brain.
- Selective labeling of sensory hair cells and neurons in auditory, vestibular, and lateral line systems by a monoclonal antibody.
- Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping population of neocortical neurons in vitro.
- Neurotrophic factors in the CNS: biosynthetic processing and functional responses.
- Transient appearance of beta-endorphin immunoreactive cells within the germinal zone of neonatal rat forebrain.
- The use of microPET for the development of neural repair therapeutics: studies in Epilepsy and lesion models.
- Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development.
- From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs.
- Conversational repair in pediatric Epilepsy.
- OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes.
- Cysteine string proteins are associated with cortical granules of Xenopus laevis oocytes.
- A genetic analysis of neural progenitor differentiation.
- Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
- Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells.
- In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET).
- Developmental expression of OSP/claudin-11.
- Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption.
- Expression of the EGF receptor family members ErbB2, ErbB3, and ErbB4 in germinal zones of the developing brain and in neurosphere cultures containing CNS stem cells.
- Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system.
- Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe Epilepsy patients.
- Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic Epilepsy.
- Altered hippocampal kainate-receptor mRNA levels in temporal lobe Epilepsy patients.
- Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe Epilepsy patients and a rodent model of chronic mesial limbic Epilepsy.
- Electrical and optical monitoring of alpha-latrotoxin action at Drosophila neuromuscular junctions.
- Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor.
- A Xenopus cysteine string protein with a cysteine residue in the J domain.
- Human hippocampal AMPA and NMDA mRNA levels in temporal lobe Epilepsy patients.
- Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain.
- Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain.
- A subpopulation of striatal gabaergic neurons expresses the epidermal growth factor receptor.
- Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target.
- PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase.
- Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures.
- Metabolic correlates of lesion-specific plasticity: an in vivo imaging study.
- [Cancer stem cells in pediatric brain tumors].
- Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones--implications for stem cell biology.
Schools
University of California At Irvine California College of Medicine amp Surgery
UCLA Med CtrUCLA D Geffen School
Procedures Preformed
- EEG (Electroencephalogram)
Conditions Treated
- Convulsions
- Epilepsy
- Headache
- Migraine
Doctors Specialties
- Pediatric Neurology
- Neurology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- CaliforniaCare HMO
- Advantage Preferred DirectAccess Plus PPO
- Blue Cross Blue Shield of California PPO
- Pathway X Direct Access PPO
- Pathway X Tiered Direct Access
- Select Plus HMO
- Select PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- CoreSource
- First Health (Coventry Health Care) PPO
- Blue & Gold HMO
- Covered California - Bronze PPO
- Employer Group HMO
- Health Net PPO
- Individual and Family PPO
- Medicaid
- Medicare MCR
- Kaiser PHCS Network PPO
- MultiPlan PPO
- PHCS Network PPO
- Heritage Signature
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- PacifiCare HMO
- United Healthcare
Awards
- CMS Meaningful Use Stage 1 Certification
- Super Doctor
Education
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UCLA Medical Center -
University of California Irvine School of Medicine
Hospital
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Mattel Children's Hospital UCLA -
Ronald Reagan UCLA Medical Center
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