Dean of Medicine and Biologic Sciences; Frank L. Day Professor of Biology; Professor of Medicine; Professor of Molecular Microbiology and Immunology; Professor of Molecular Biology, Cell Biology and Biochemistry; Brown University; Warren Alpert Medi
Pulmonology
Dr. Jack A. Elias, MD
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Jack A. Elias, MD practices Pulmonology. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. He received awards:"Councilor", "Member", "President" and "Elected Member". Jack Elias is a published MD. He published 101 publications, including: 'Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9.'
Publications
- Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9.
- Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection.
- Role of chitinase 3-like-1 and semaphorin 7a in Pulmonary melanoma metastasis.
- Chitinase 3-like-1 Regulates both Visceral Fat Accumulation and Asthma-like Th2 Inflammation.
- Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis.
- Modifiers of TGF-β1 effector function as novel therapeutic targets of Pulmonary fibrosis.
- Chitinase 3-like 1 Synergistically Activates IL6-mediated STAT3 Phosphorylation in Intestinal Epithelial Cells in Murine Models of Infectious Colitis.
- MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury.
- VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis.
- Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling.
- Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2.
- Fatty Acid Binding Protein 4 Regulates VEGF-Induced Airway Angiogenesis and Inflammation in a Transgenic Mouse Model: Implications for Asthma.
- Chitinase-Like Protein Brp-39/YKL-40 Modulates the Renal Response to Ischemic Injury and Predicts Delayed Allograft Function.
- Semaphorin 7a+ Regulatory T Cells Are Associated with Progressive Idiopathic Pulmonary Fibrosis and Are Implicated in Transforming Growth Factor-?1-induced Pulmonary F...
- IL-13 receptor ?2-arginase 2 pathway mediates IL-13-induced Pulmonary hypertension.
- Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis.
- Chitinase 3-like-1 Promotes Streptococcus pneumoniae Killing and Augments Host Tolerance to Lung Antibacterial Responses.
- IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13.
- Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2.
- Studies of vascular endothelial growth factor in asthma and chronic obstructive Pulmonary disease.
- Modern concepts on the role of inflammation in Pulmonary fibrosis.
- Local apoptosis promotes collagen production by monocyte-derived cells in transforming growth factor β1-induced lung fibrosis.
- IL-13 in Asthma: The Successful Integration of Lessons from Mice and Humans.
- Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.
- Rig-Like Helicase Innate Immunity Inhibits VEGF Tissue Responses via A Type I Interferon-Dependent Mechanism.
- Chitin particles are multifaceted immune adjuvants.
- Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.
- The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury.
- Getting from genes to function in lung disease: a National Heart, Lung, and Blood Institute workshop report.
- Role of Breast Regression Protein (BRP)-39 in the Pathogenesis of Cigarette Smoke-Induced Inflammation and Emphysema.
- Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.
- Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.
- Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.
- Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism.
- Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis.
- Chitin is a size-dependent regulator of macrophage TNF and IL-10 production.
- Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy.
- Novel biomarkers in asthma: chemokines and chitinase-like proteins.
- Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.
- Acidic mammalian chitinase is secreted via an ADAM17/epidermal growth factor receptor-dependent pathway and stimulates chemokine production by Pulmonary epithelial cells.
- Developmental regulation of NO-mediated VEGF-induced effects in the lung.
- TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
- Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis.
- Cigarette smoke selectively enhances viral PAMP- and virus-induced Pulmonary innate immune and remodeling responses in mice.
- Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
- P21 regulates TGF-beta1-induced Pulmonary responses via a TNF-alpha-signaling pathway.
- IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
- A chitinase-like protein in the lung and circulation of patients with severe asthma.
- Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
- Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia.
- Semaphorin 7A plays a critical role in TGF-beta1-induced Pulmonary fibrosis.
- The role of angiopoietin 2 in hyperoxia-induced acute lung injury.
- VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo.
- Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice.
- Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge.
- Transforming growth factor (TGF)-beta1 stimulates Pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase...
- IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced Pulmonary emphysema and inflammation.
- Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.
- Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in Pulmonary fibroblasts.
- Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation.
- IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema.
- Role of 5-lipoxygenase in IL-13-induced Pulmonary inflammation and remodeling.
- State of the art. Mechanistic heterogeneity in chronic obstructive Pulmonary disease: insights from transgenic mice.
- Genetic control of transforming growth factor-beta1-induced emphysema and fibrosis in the murine lung.
- Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.
- Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung.
- Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling.
- Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis.
- Role of CCR5 in the pathogenesis of IL-13-induced inflammation and remodeling.
- Association between genetic variations of vascular endothelial growth factor receptor 2 and atopy in the Korean population.
- Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.
- Partially adenosine deaminase-deficient mice develop Pulmonary fibrosis in association with adenosine elevations.
- ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
- Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent.
- Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.
- Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma.
- Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability.
- Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and Pulmonary emphysema.
- Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response.
- Lipid let loose in Pulmonary emphysema.
- Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury.
- IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.
- Airway remodeling in asthma: therapeutic implications of mechanisms.
- Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchoPulmonary dysplasia?
- Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways.
- Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.
- Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced Pulmonary fibrosis.
- Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness.
- Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.
- The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling.
- Asthma: mechanisms of disease persistence and progression.
- Interleukin-11 and interleukin-6 protect cultured human endothelial cells from H2O2-induced cell death.
- Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia.
- Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway.
- Apoptosis and emphysema: the missing link.
- Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions.
- Interleukin-13 and leukotrienes: an intersection of pathogenetic schema.
- Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro.
- Transgenic modeling of interleukin-13 in the lung.
- Interleukin-13 induces surfactant function abnormality in the murine lung.
Schools
Perelman School of Medicine University of Pennsylvania
Tufts New England Med Center
Hospital Of The University Of Pennsylvania
Conditions Treated
- Pulmonary Hypertension
- Sarcoidosis
- Sleep Apnea
- Systemic Sclerosis
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Doctors Specialties
- Critical Care Medicine
- Pulmonology
Accepted Insurances
Awards
- Councilor
- Member
- President
- Elected Member
Education
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University of Pennsylvania Health System -
Tufts Medical Center -
Perelman School of Medicine at the University of Pennsylvania
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