Professor, Medicine, Perelman School of Medicine
Oncology
Dr. James A. Hoxie, MD
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James Hoxie is an expert in the field of Oncology. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. He has 2 awards "Elected Member" and "Whos Who in Medicine and Healthcare". Dr. James A. Hoxie is a published physician. He has 51 papers published. The most current publication "Elite control, gut CD4 T cell sparing, and enhanced mucosal T cell responses in Macaca nemestrina infected by an SIV lacking a gp41 trafficking motif."
Publications
- Elite control, gut CD4 T cell sparing, and enhanced mucosal T cell responses in Macaca nemestrina infected by an SIV lacking a gp41 trafficking motif.
- Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques.
- Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer.
- Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor.
- Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques.
- Quantification of Entry Phenotypes of Macrophage-Tropic HIV-1 across a Wide Range of CD4 Densities.
- A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T-cells.
- CD4+ T Cells Support Production of Simian Immunodeficiency Virus Env Antibodies That Enforce CD4-Dependent Entry and Shape Tropism In Vivo.
- Translating social and behavioral science research to the AIDS epidemic: a center for AIDS research perspective.
- Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent Disease pro...
- Novel Cell and Gene Therapies for HIV.
- Blockade of lymphocyte chemotaxis in visceral Graft-versus-host disease.
- 3D structures of sCD4-bound States of trimeric SIV envelope glycoproteins determined using cryo-electron tomography.
- Structure-Based Identification and Neutralization Mechanism of Tyrosine Sulfate Mimetics That Inhibit HIV-1 Entry.
- High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.
- A HIV-1 gp120 Envelope Human Monoclonal Antibody that Recognizes a C1 Conformational Epitope Mediates Potent ADCC Activity and Defines a Common ADCC Epitope in Human H...
- Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases.
- Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5.
- Distinct molecular pathways to X4 tropism for a V3-truncated human immunodeficiency virus type 1 lead to differential coreceptor interactions and sensitivity to a CXCR...
- Toward an antibody-based HIV-1 vaccine.
- Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure.
- Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.
- Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.
- Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain.
- Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor.
- Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma.
- Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization.
- HIV vaccine research: the way forward.
- Effects of partial deletions within the human immunodeficiency virus type 1 V3 loop on coreceptor tropism and sensitivity to entry inhibitors.
- Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.
- V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies.
- Tuberculosis and HIV coinfection: genesis of the supplement and sponsors' contribution.
- Vaccine-delivered HIV envelope inhibits CD4(+) T-cell activation, a mechanism for poor HIV vaccine responses.
- A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.
- A plea for justice for jailed medical workers.
- DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets.
- Simian immunodeficiency virus (SIV)/immunoglobulin G Immune complexes in SIV-infected macaques block detection of CD16 but not cytolytic activity of natural killer cells.
- Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail.
- Characterization of neutralizing antibodies to West Nile virus.
- Antigenic conservation and immunogenicity of the HIV coreceptor binding site.
- Vaccination with an inactivated virulent feline immunodeficiency virus engineered to express high levels of Env.
- Public health. A sound rationale needed for phase III HIV-1 vaccine trials.
- CCR5 mimicry by sulfated human anti-HIV-1 antibodies.
- Identification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.
- Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.
- Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficie...
- Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex.
- Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope protein.
- Trophoblasts are productively infected by CD4-independent isolate of HIV type 1.
- Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions.
Schools
University Of Pennsylvania School Of Medicine
Rhode Island Hospital Lifespan
University Of Pa Health System
Procedures Preformed
- HPC Transplantation (Stem Cell Transplant)
Conditions Treated
- Acute Leukemia
- Anemia
- Chronic Myeloid Leukemia (CML)
- Graft vs Host Disease
- View All
Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
Education
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University of Pennsylvania Health System -
Brown University -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Hospital of the University of Pennsylvania -
Penn Presbyterian Medical Center
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