Physician

Cardiology

Doctor James A. Schafer, MD is an expert in the field of Cardiology. He attended University of Michigan Medical School. He has 3 awards "Meaningful Use Stage 1 Certification", "Elected Member" and "Fellow (FACC)". James Schafer is a published doctor as well. He has 40 publications published. The latest was: Dopamine D4 receptor isoform mRNA and protein are expressed in the rat cortical collecting duct.

Publications

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• Endogenous ATP release inhibits electrogenic Na⁺ absorption and stimulates Cl⁻ secretion in MDCK cells.
• Experimental validation of the countercurrent model of urinary concentration.
• Inhibition of ENaC by intracellular Cl- in an MDCK clone with high ENaC expression.
• Renal water reabsorption: a physiologic retrospective in a molecular era.
• Abnormal regulation of ENaC: Syndromes of salt retention and salt wasting by the collecting duct.
• cAMP increases density of ENaC subunits in the apical membrane of MDCK cells in direct proportion to amiloride-sensitive Na(+) transport.
• Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium.
• Interaction of modeling and experimental approaches to understanding renal salt and water balance.
• Fluid absorption and active and passive ion flows in the rabbit superficial pars recta.
• The collecting duct, dopamine and vasopressin-dependent Hypertension.
• Dopamine D4 receptor isoform mRNA and protein are expressed in the rat cortical collecting duct.
• Expression of multiple alpha-adrenoceptor isoforms in rat CCD.
• Dopamine inhibits vasopressin-dependent cAMP production in the rat cortical collecting duct.
• Low Na+ diet inhibits Na+ and water transport response to vasopressin in rat cortical collecting duct.
• Microtubule disruption inhibits AVT-stimulated Cl- secretion but not Na+ reabsorption in A6 cells.
• A simplified method for isolation of large numbers of defined nephron segments.
• Effects of sodium nitroprusside in the rat cortical collecting duct are independent of the NO pathway.
• cGMP-activating peptides do not regulate electrogenic electrolyte transport in principal cells of rat CCD.
• AVP and aldosterone at physiological concentrations have synergistic effects on Na+ transport in rat CCD.
• Dopamine inhibits AVP-dependent Na+ transport and water permeability in rat CCD via a D4-like receptor.
• Differential expression of PKC isoforms in fresh and cultured rabbit CCD.
• Sodium and water transport in cortical collecting duct of Dahl salt-resistant rat.
• 1993 Homer W. Smith Award. Salt and water homeostasis--is it just a matter of good bookkeeping?
• Intracellular Ca2+ and PKC activation do not inhibit Na+ and water transport in rat CCD.
• Inhibition by epinephrine of AVP- and cAMP-stimulated Na+ and water transport in Dahl rat CCD.
• Clonidine, but not bradykinin or ANP, inhibits Na+ and water transport in Dahl SS rat CCD.
• AVP stimulates Na+ transport in primary cultures of rabbit cortical collecting duct cells.
• Regulation of Na+ channels in the cortical collecting duct by AVP and mineralocorticoids.
• Clonidine and PGE2 have different effects on Na+ and water transport in rat and rabbit CCD.
• Effects of AVP and deoxycorticosterone on Na+ and water transport in the Dahl salt-sensitive rat CCD.
• Na+ transport in isolated rat CCD: effects of bradykinin, ANP, clonidine, and hydrochlorothiazide.
• cAMP mediates the increase in apical membrane Na+ conductance produced in rat CCD by vasopressin.
• Differences in synergistic actions of vasopressin and deoxycorticosterone in rat and rabbit CCD.
• Measurement of transmural water flow in isolated perfused tubule segments.
• Vasopressin and mineralocorticoid increase apical membrane driving force for K+ secretion in rat CCD.
• Transepithelial osmolality differences, hydraulic conductivities, and volume absorption in the proximal tubule.
• Stimulation of sodium transport by aldosterone and arginine vasotocin in A6 cells.
• Cortical interstitium as a site for solute polarization during tubular absorption.
• Electrophysiological studies in principal cells of rat cortical collecting tubules. ADH increases the apical membrane Na+-conductance.

Schools

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• University of Mi Med Sch

• University Tex Sw

• University Tex Sw Affil Hosps

• William Beaumont Hospital

Procedures Preformed

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• Ablation for Treatment of Cardiac Arrhythmias
• Cardiac Catheterization (incl. Coronary Angiography)
• Cardiac Imaging
• Cardiac Myocardial Perfusion Imaging
• View All

Conditions Treated

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• Aneurysm and Dissection of Heart
• Angina and Acute Coronary Syndrome
• Aortic Aneurysm
• Aortic Dissection
• View All

Doctors Specialties

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• Cardiology

Accepted Insurances

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Awards

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• Meaningful Use Stage 1 Certification
• Elected Member
• Fellow (FACC)

Education

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• William Beaumont Hospital
• University of Michigan Medical School

Hospital

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• McLaren Greater Lansing

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