Associate Professor, Pathology and Laboratory Medicine, Emory University School of Medicine
Pathology
Dr. James C. Zimring, MD
Doctor James C. Zimring, MD is an expert in the field of Pathology. He went to medical school at Emory University School of Medicine. Emory University School of Medicine is ranked 23/42 in Research/PrimaryCare. He received 1 awards: "Elected Member". James Zimring has written publications. He has 68 publications published with PubMed. The lastest paper is: 'Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription.'
Publications
- Erythrophagocytosis by plasmacytoid dendritic cells and monocytes is enhanced during inflammation.
- Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models.
- Macrophages clear refrigerator storage-damaged red blood cells and subsequently secrete cytokines in vivo, but not in vitro, in a murine model.
- Antigen Modulation Confers Protection to Red Blood Cells from Antibody through Fcγ Receptor Ligation.
- Transfusion-Induced Bone Marrow Transplant Rejection Due to Minor Histocompatibility Antigens.
- Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks.
- A novel role for C3 in antibody-induced red blood cell clearance and antigen modulation.
- Transfusion of murine red blood cells expressing the human KEL glycoprotein induces clinically significant alloantibodies.
- Frequency of glucose-6-phosphate dehydrogenase-deficient red blood cell units in a metropolitan transfusion service.
- On the appropriate use and interpretation of animal models in transfusion medicine research.
- Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization.
- Initiation and Regulation of Complement during Hemolytic Transfusion Reactions.
- Biphasic clearance of incompatible red blood cells through a novel mechanism requiring neither complement nor Fcγ receptors in a murine model.
- Generation of transgenic mice with antithetical KEL1 and KEL2 human blood group antigens on red blood cells.
- Transfusion in the absence of inflammation induces antigen specific tolerance to murine RBCs.
- Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.
- Alloimmunization to transfused platelets requires priming of CD4+ T cells in the splenic microenvironment in a murine model.
- Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease.
- Transfusion of fresh murine red blood cells reverses adverse effects of older stored red blood cells.
- Rapid clearance of transfused murine red blood cells is associated with recipient cytokine storm and enhanced alloimmunogenicity.
- Recent developments and future directions of alloimmunization to transfused blood products.
- Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.
- Regulation of primary alloantibody response through antecedent exposure to a microbial T-cell epitope.
- Storage of murine red blood cells enhances alloantibody responses to an erythroid-specific model antigen.
- Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model.
- To RBC or not to RBC: the role of suicidal death in hemolytic transfusion reactions.
- Transfusion of minor histocompatibility antigen-mismatched platelets induces rejection of bone marrow transplants in mice.
- The spleen plays a central role in primary humoral alloimmunization to transfused mHEL red blood cells.
- A novel mouse model of red blood cell storage and posttransfusion in vivo survival.
- Antigen loss from antibody-coated red blood cells.
- Does a febrile reaction to platelets predispose recipients to red blood cell alloimmunization?
- An autoanti-Kp b immunoglobulin M that simulates antigen suppression.
- Hypothesis: hemolytic transfusion reactions represent an alternative type of anaphylaxis.
- The role of inflammation in alloimmunization to antigens on transfused red blood cells.
- Lessons learned from mouse models of hemolytic transfusion reactions.
- Discrete Toll-like receptor agonists have differential effects on alloimmunization to transfused red blood cells.
- Cytokine storm in a mouse model of IgG-mediated hemolytic transfusion reactions.
- Blood donation and blood transfusion: special considerations for African Americans.
- Transfusion-induced autoantibodies and differential immunogenicity of blood group antigens: a novel hypothesis.
- Inflammation enhances consumption and presentation of transfused RBC antigens by dendritic cells.
- Nonhemolytic antigen loss from red blood cells requires cooperative binding of multiple antibodies recognizing different epitopes.
- Ovalbumin serves as a neo-transplantation antigen in retinal pigment epithelial cells.
- Transfusion-transmitted cytomegalovirus: lessons from a murine model.
- Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells.
- Performance characteristics of two real-time PCR assays for the quantification of Epstein-Barr virus DNA.
- Rapamycin prolongs susceptibility of responding T cells to tolerance induction by CD8+ veto cells.
- Immunization to minor histocompatibility antigens on transfused RBCs through crosspriming into recipient MHC class I pathways.
- Nonhemolytic antibody-induced loss of erythrocyte surface antigen.
- Effect of mediators of innate immunity and inflammation on CD8+ veto cells.
- Appropriate use of recombinant factor VIIa: an expanding and unanswered question.
- Short duration of elevated vIRF-1 expression during lytic replication of human herpesvirus 8 limits its ability to block antiviral responses induced by alpha interfero...
- Identification and characterization of CD8+ suppressor T cells.
- Pathobiology of transfusion reactions.
- Current problems and future directions of transfusion-induced alloimmunization: summary of an NHLBI working group.
- Alloimmunization against RBC or PLT antigens is independent of TRIM21 expression in a murine model.
- Analysis of CD8+ T cell-mediated anti-viral responses in mice with targeted deletions of the M1 or M5 muscarinic cholinergic receptors.
- Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway.
- CD75s is a marker of murine CD8(+) suppressor T cells.
- Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription.
- CD40 ligation induced phenotypic and functional expression of CD80 by human cardiac microvascular endothelial cells.
- Transcriptional activation by the human herpesvirus-8-encoded interferon regulatory factor.
- Cross-linking induces non-haemolytic antigen-loss from transfused red blood cells: a potential role for rheumatoid factor.
- Use of mouse models to study the mechanisms and consequences of RBC clearance.
- MHC II on transfused murine blood is not required for alloimmunization against MHC I.
- Minor antigens on transfused RBCs crossprime CD8 T cells but do not induce full effector function.
- Prevention of transfusion-transmitted cytomegalovirus in low-birth weight infants (≤1500 g) using cytomegalovirus-seronegative and leukoreduced t...
- Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells.
Schools
Emory University
Emory University School Of Med
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Awards
- Elected Member
Education
-
Emory University -
Emory University School of Medicine
Hospital
-
Emory University Hospital
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