Professor, Medicine, University of Colorado School of Medicine

Pulmonology

James Crapo, MD is an expert in the field of Pulmonology. He went to University of Rochester School of Medicine and Dentistry. He over the years received 1 awards: "Elected Member". James Crapo is a published doctor. He published 94 publications, including: 'A genome-wide analysis of the response to inhaled 2-agonists in chronic obstructive pulmonary disease.'

Publications

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• A genome-wide analysis of the response to inhaled β2-agonists in Chronic obstructive pulmonary disease.
• β-Blockers are associated with a reduction in COPD exacerbations.
• The beneficial effects of exercise on cartilage are lost in mice with reduced levels of ECSOD in tissues.
• Comparison between an Alternative and the Classic Definition of Chronic Bronchitis in COPDGene.
• Reduced Bone Density and Vertebral Fractures in Smokers: Men and COPD Patients at Increased Risk.
• Smoking Associated Site Specific Differential Methylation in Buccal Mucosa in the COPDGene Study.
• Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study.
• Association between Occupational Exposure and Lung Function, Respiratory Symptoms, and High-Resolution Computed Tomography Imaging in COPDGene.
• Childhood-onset asthma in smokers: Association between CT measures of airway size, lung function and Chronic airflow obstruction.
• Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene.
• Genome-Wide Association Identifies Regulatory Loci Associated with Distinct Local Histogram Emphysema Patterns.
• Common Genetic Variants Associated with Resting Oxygenation in Chronic Obstructive Pulmonary Disease.
• The clinical and genetic features of COPD-asthma overlap syndrome.
• Cardiovascular Disease is Associated with COPD Severity and Reduced Functional Status and Quality of Life.
• Chronic Obstructive Pulmonary Disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases.
• Risk loci for Chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
• Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema.
• Genome-wide Study of Percent Emphysema on CT in the General Population: The MESA Lung/SHARe Study.
• The clinical impact of non-obstructive Chronic bronchitis in current and former smokers.
• Pulmonary Function Reduction in Diabetes Mellitus with and without Chronic Obstructive Pulmonary Disease.
• Distinct Quantitative CT Emphysema Patterns are Associated with Physiology and Function in Smokers.
• The COPD Biomarker Qualification Consortium (CBQC).
• Computed Tomographic Measures of Pulmonary Vascular Morphology in Smokers and their Clinical Implications.
• Genome-wide association study identifies multiple susceptibility loci for Pulmonary fibrosis.
• GOLD 2011 disease severity classification in COPDGene: a prospective cohort study.
• Racial Differences in CT Phenotypes in COPD.
• Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.
• Chronic Obstructive Pulmonary Disease: Lobe-based Visual Assessment of Volumetric CT by Using Standard Images--Comparison with Quantitative CT and Pulmonary Function T...
• The Antioxidant, MnTE-2-PyP, Prevents Side-Effects Incurred by Prostate Cancer Irradiation.
• The clinical features of the overlap between COPD and asthma.
• Elastase Inhibitory Activity of Airway ?1-Antitrypsin is Protected by Treatment with a Catalytic Antioxidant in a Baboon Model of Severe BronchoPulmonary Dysplasia.
• Extracellular superoxide dismutase in macrophages augments bacterial killing by promoting phagocytosis.
• Smoking and COPD increase sputum levels of extracellular superoxide dismutase.
• Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPDGene study.
• An oxidative environment promotes growth of Mycobacterium abscessus.
• Genome-Wide Association Analysis of Body Mass in Chronic Obstructive Pulmonary Disease.
• The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis.
• Extracellular superoxide dismutase protects against Pulmonary emphysema by attenuating oxidative fragmentation of ECM.
• Redox modulation protects islets from transplant-related injury.
• Preclinical vascular disease identifies smokers at risk for COPD.
• A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model.
• Variants in FAM13A are associated with Chronic obstructive pulmonary disease.
• Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.
• The antioxidant mimetic, MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus.
• Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells.
• Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchoPulmonary dysplasia.
• Extracellular superoxide dismutase haplotypes are associated with acute Lung injury and mortality.
• Superoxide dismutase 3 polymorphism associated with reduced Lung function in two large populations.
• Decreased Pulmonary extracellular superoxide dismutase during systemic inflammation.
• The folding of human active and inactive extracellular superoxide dismutases is an intracellular event.
• Bombesin-like peptides modulate alveolarization and angiogenesis in bronchoPulmonary dysplasia.
• N-acetylcysteine and exacerbations of Chronic obstructive pulmonary disease.
• Improved lung growth and function through hypoxia-inducible factor in primate Chronic lung disease of prematurity.
• The burden of tobacco on life and health and the voice of the Journal of COPD.
• Induction of antioxidant gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species.
• Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species ...
• The mysterious Pulmonary brush cell: a cell in search of a function.
• Memory decline of aging reduced by extracellular superoxide dismutase overexpression.
• Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal Chronic lung disease.
• Lung inflation with direct injection of agarose: a technique for simultaneous molecular and morphometric measurements.
• The structure of rabbit extracellular superoxide dismutase differs from the human protein.
• Colocalization of eNOS and the catalytic subunit of PKA in endothelial cell junctions: a clue for regulated NO production.
• The intracellular proteolytic processing of extracellular superoxide dismutase (EC-SOD) is a two-step event.
• Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation.
• Editorial: the Journal of COPD--new directions in disease understanding and management.
• Superoxide dismutases in malignant cells and human tumors.
• The role of oxidative stress in Chronic obstructive pulmonary disease.
• The dual nature of human extracellular superoxide dismutase: one sequence and two structures.
• Redox active agents in inflammatory Lung injury.
• Superoxide dismutases in the lung and human lung Diseases.
• Preischemic and postischemic administration of AEOL10113 reduces infarct size in a rat model of myocardial ischemia and reperfusion.
• Clinical research in Chronic obstructive pulmonary disease: needs and opportunities.
• Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced Lung injury.
• Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species.
• Inhibition of airway inflammation and hyperreactivity by a catalytic antioxidant.
• Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure.
• A catalytic antioxidant attenuates alveolar structural remodeling in bronchoPulmonary dysplasia.
• Oxidative stress in airways: is there a role for extracellular superoxide dismutase?
• Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity.
• Regulation of the brain's vascular responses to oxygen.
• A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.
• Inhibition of tobacco smoke-induced Lung inflammation by a catalytic antioxidant.
• Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia.
• Oxidative stress in allergic respiratory Diseases.
• Inhibition of airway inflammation and hyperreactivity by an antioxidant mimetic.
• Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase.
• Role of extracellular superoxide dismutase in bleomycin-induced Pulmonary fibrosis.
• Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice.
• Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans.
• Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and Chronic proctitis following focal proton irradiation of the rat rectum.
• Impact of self-reported Gastroesophageal reflux disease in subjects from COPDGene cohort.
• A Simplified Score to Quantify Comorbidity in COPD.
• Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD.

Schools

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• University Of Rochester School Of Medicine and Dentistry

• Harbor Hospital Center Program

• Duke University Hospital Program

Conditions Treated

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• COPD (Chronic Obstructive Pulmonary Disease)
• Lung Nodule

Doctors Specialties

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• Pulmonology

Accepted Insurances

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• Aetna HMO
• Choice Plus POS II

Awards

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• Elected Member

Education

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• Duke University Hospital
• Harbor - UCLA Medical Center
• University of Rochester School of Medicine and Dentistry

Hospital

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• National Jewish Health
• Duke University Hospital

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