Associate Clinical Professor of Pathology, Massachusetts General Hospital
Pathology
Dr. James T. Kurnick, MD
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James T. Kurnick is an expert in the field of Pathology. He attended Tufts University School of Medicine. Tufts University School of Medicine is ranked 49 in research and 52 in primary care medicine Doctor James T. Kurnick, MD is a published MD. He published 88 publications, including: 'PHA-induced activation of suppressor cells in normal human peripheral blood lymphocytes.'
Publications
- A Screening Assay to Identify Agents That Enhance T Cell Recognition of Human Melanomas.
- Enhancement of human melanoma antigen expression by IFN-beta.
- Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expression.
- Induction of "antigen silencing" in melanomas by oncostatin M: down-modulation of melanocyte antigen expression.
- Skewed T-cell receptor repertoire: more than a marker of malignancy, a tool to dissect the immunopathology of inflammatory diseases.
- Studies on the mode of action of diphtheria toxin. VII. Toxin-stimulated hydrolysis of nicotinamide adenine dinucleotide in mammalian cell extracts.
- Strategies to overcome obstacles to successful immunotherapy of melanoma.
- Long-term maintenance of HLA-D restricted T cells specific for soluble antigens.
- Studies of the mechanism of cytolysis by tumour-infiltrating lymphocytes.
- Melanoma antigen recognition by tumour-infiltrating T lymphocytes (TIL): effect of differential expression of melan-A/MART-1.
- Release of gram-negative outer-membrane proteins into human serum and septic rat blood and their interactions with immunoglobulin in antiserum to Escherichia coli J5.
- Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum.
- A novel autocrine pathway of tumor escape from immune recognition: melanoma cell lines produce a soluble protein that diminishes expression of the gene encoding the me...
- Lymphocyte activation antigens. I. A monoclonal antibody, anti-Act I, defines a new late lymphocyte activation antigen.
- Different expression of Lyt differentiation antigens and cell surface glycoproteins by a murine T lymphoma line and its highly metastatic variant.
- Helper and suppressor-inducer activity of human T cells and their cloned progeny maintained in long-term culture.
- Modulation of surface antigens of a human monocyte cell line, U937, during incubation with T lymphocyte-conditioned medium: detection of T4 antigen and its presence on...
- T-cell subsets in human lymphocytes maintained in IL-2 medium after PHA or mixed lymphocyte reaction activation.
- Biochemical comparison of HLA-DR molecules derived from autologous human T and B lymphoblasts.
- Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells.
- Separation of mitogen-induced suppressor cells of human antibody-producing cells.
- 1 alpha,25-dihydroxyvitamin D3 induces maturation of the human monocyte cell line U937, and, in association with a factor from human T lymphocytes, augments production...
- T cell growth factor-enhanced PHA response of human thymus cells: requirement for T3+ cells.
- Modulation of synovial cell products by a factor from a human cell line: T lymphocyte induction of a mononuclear cell factor.
- Responses of human T cells to dominant discrete protein antigens of Escherichia coli and Pseudomonas aeruginosa.
- T cell receptors in rheumatoid arthritis.
- Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR reper...
- Phenotypic characteristics of lymphocyte populations isolated from middle gestation human placenta.
- Phenotypic characteristics of lymphoid populations of middle gestation human fetal liver, spleen and thymus.
- T cell receptor gene rearrangements and cytotoxic activities of clones isolated from tumour-infiltrating lymphocytes (TIL) from melanoma patients.
- T-cell receptor V-gene usage in synovial fluid lymphocytes of patients with chronic arthritis.
- T lymphocyte responses to antigens of gram-negative bacteria in pyelonephritis.
- Fibroblast-derived factors preserve viability in vitro of mononuclear cells isolated from subjects with HIV-1 infection.
- Escherichia coli and Pseudomonas aeruginosa induce expansion of V delta 2 cells in adult peripheral blood, but of V delta 1 cells in cord blood.
- In vivo accumulation of the same anti-melanoma T cell clone in two different metastatic sites.
- T cell receptor usage by HLA-DR3-specific T cell clones isolated from a renal allograft.
- Antiserum against Escherichia coli J5 contains antibodies reactive with outer membrane proteins of heterologous gram-negative bacteria.
- Oligoclonality of Vdelta1 and Vdelta2 cells in human peripheral blood mononuclear cells: TCR selection is not altered by stimulation with gram-negative bacteria.
- Long term growth in vitro of human T cell blasts with maintenance of specificity and function.
- Propagation of antigen-specific T cell helper function in vitro.
- A rapid method for the separation of functional lymphoid cell populations of human and animal origin on PVP-silica (Percoll) density gradients.
- Rosette formation with goat erythrocytes. A marker for human T lymphocytes.
- In vivo generation of mouse natural killer cells: role of the spleen and thymus.
- Mitogen activation of human chronic lymphatic leukemia cells. I. Synthesis and secretion of immunoglobulin.
- PHA-induced activation of suppressor cells in normal human peripheral blood lymphocytes.
- Relationship between immunoglobulin-bearing lymphocytes and cells reactive with sensitized human erythrocytes.
- Dominant rearrangements among human tumor-infiltrating lymphocytes. Analysis of T-cells derived from 32 patients with melanoma, lung, and renal cell carcinoma.
- T cell heterogeneity in patients with common variable immunodeficiency as assessed by abnormalities of T cell subpopulations and T cell receptor gene analysis.
- Cytotoxic activity of graft-infiltrating lymphocytes correlates with cellular rejection in cardiac transplant patients.
- Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor-infiltrating lymphocytes.
- Adoptive immunotherapy with recombinant interleukin 2, LAK and TIL.
- Expression of HLA-A2 antigen in human melanoma cell lines and its role in T-cell recognition.
- Clonal analysis of graft-infiltrating lymphocytes from renal and cardiac biopsies. Dominant rearrangements of TcR beta genes and persistence of dominant rearrangements...
- Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells.
- Alterations in pulmonary function in cancer patients receiving adoptive immunotherapy with tumor-infiltrating lymphocytes and interleukin-2.
- Clonal dominance among synovial tissue-infiltrating lymphocytes in arthritis.
- Immunotherapy of human cancers with tumor-infiltrating lymphocytes and systemic infusions of interleukin-2.
- Escherichia coli-specific T lymphocytes in experimental pyelonephritis.
- Characterization of the CD4+ and CD8+ tumor infiltrating lymphocytes propagated with bispecific monoclonal antibodies.
- Adoptive immunotherapy of murine pulmonary metastases with interleukin 2 and interferon-gamma.
- Tumour-infiltrating lymphocytes and interleukin-2 in treatment of advanced cancer.
- Interleukin 1 production by the human monocyte cell line U937 requires a lymphokine induction signal distinct from interleukin 2 or interferons.
- Characteristics of lymphocytes cultured from murine viral myocarditis specimens: a preliminary and technical report.
- Adoptive immunotherapy with IL-2 results in the loss of delayed-type hypersensitivity responses and the development of immediate hypersensitivity to recall antigens.
- Factor XIII A is synthesized and expressed on the surface of U937 cells and alveolar macrophages.
- Clonal dominance among T-lymphocyte infiltrates in arthritis.
- T lymphocyte infiltrates in inflammatory synovia are oligoclonal.
- T lymphocytes in synovia of patients with rheumatoid arthritis.
- Functional characterization of T lymphocytes propagated from human lung carcinomas.
- Two-color flow cytometry and functional analysis of lymphocytes cultured from human renal allografts: identification of a Leu-2+3+ subpopulation.
- Characterization of in vivo-activated allospecific T lymphocytes propagated from human renal allograft biopsies undergoing rejection.
- Adoptive immunotherapy of cancer with activated lymphocytes and interleukin-2.
- Tumor-derived interleukin-2-dependent lymphocytes in adoptive immunotherapy of lung cancer.
- Functional analysis of T cell subsets and clones in human renal allograft rejection.
- The poor accessory cell function of macrophages in the rat may reflect their inability to form clusters with T cells.
- Leu-M2 (Mac-120) is a platelet antigen and is not constitutively expressed by macrophages.
- Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes.
- Topoisomerase inhibitors modulate expression of melanocytic antigens and enhance T cell recognition of tumor cells.
- Treatment of patients with advanced cancer using tumor-infiltrating lymphocytes and interleukin 2.
- Immunological effects of adoptive immunotherapy with IL-2: an overview.
- Adoptive immunotherapy with interleukin-2 (IL-2) results in diminished IL-2 production by stimulated peripheral blood lymphocytes.
- Newborn T cell suppression: early appearance, maintenance in culture, and lack of growth factor suppression.
- Conditions for induction of specific and polyclonal antibody production by Cowan 1 bacteria and by pokeweed mitogen.
- The isolation and functional activity of polymorphonuclear leukocytes and lymphocytes separated from whole blood on a single percoll density gradient.
- Hereditary haemorrhagic telangiectasia: aggravation by oral contraceptives?
- Presence of a myeloproliferative factor in patients with polycythemia vera and agnogenic myeloid metaplasia. I. Expansion of the erythropoietin-responsive stem cell co...
- Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells.
Schools
Tufts University
University Colorado Med Center
Uppsala University Sweden
Doctors Specialties
- Immunology
- Pathology
Accepted Insurances
Education
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University of Colorado -
Tufts University School of Medicine
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