Physician
Allergy & Immunology
Dr. Jay A. Berzofsky, MD
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Jay A. Berzofsky practices Allergy & Immunology. He has 2 awards "Elected Member" and "Whos Who in Medicine and Healthcare". Berzofsky is a published physician. He has 101 papers published. The most current publication "Mutant KRAS conversion of conventional T cells into regulatory T cells."
Publications
- Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008).
- Tumor-induced CD11b(+) Gr-1(+) myeloid-derived suppressor cells exacerbate immune-mediated hepatitis in mice in a CD40-dependent manner.
- CD47 in the Tumor Microenvironment Limits Cooperation between Antitumor T-cell Immunity and Radiotherapy.
- Selective Inhibition of Regulatory T Cells by Targeting the PI3K-Akt Pathway.
- Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques.
- Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses.
- Episomal expression of a truncated listeriolysin O in LmddA-LLO-E7 vaccine enhances anti-tumor efficacy by preferentially inducing CD4+FoxP3- T cell and CD8+ T cell ex...
- The immunoregulatory role of type I and type II NKT cells in cancer and other diseases.
- Immune targeting of PD-1(hi) expressing cells during and after antiretroviral therapy in SIV-infected rhesus macaques.
- Cancer vaccines: 21st century approaches to harnessing an ancient modality to fight cancer.
- β-Mannosylceramide Activates Type I Natural Killer T Cells to Induce Tumor Immunity without Inducing Long-Term Functional Anergy.
- Delicate Balance among Three Types of T Cells in Concurrent Regulation of Tumor Immunity.
- Large intestine-targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection.
- Strategies to use immune modulators in therapeutic vaccines against cancer.
- A push-pull vaccine strategy using Toll-like receptor ligands, IL-15, and blockade of negative regulation to improve the quality and quantity of T cell immune responses.
- A Novel Combination Immunotherapy for Cancer by IL-13R?2-Targeted DNA Vaccine and Immunotoxin in Murine Tumor Models.
- TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4⺠memory T cell loss in SIVmac251-challenged rhesus macaques.
- Lack Of IL-7 And IL-15 Signaling Affects Interferon-gamma Production by, More than Survival of, Small Intestinal Intraepithelial Memory CD8(+) T Cells.
- A gynecologic oncology group phase II trial of two p53 peptide vaccine approaches: subcutaneous injection and intravenous pulsed dendritic cells in high recurrence ris...
- KLF13 sustains thymic memory-like CD8+ T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.
- IL-15 ex vivo overcomes CD4+ T cell deficiency for the induction of human antigen-specific CD8+ T cell responses.
- Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity.
- Multiple antigen peptide vaccines against Plasmodium falciparum malaria.
- Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques.
- Blockade of TGF-beta enhances tumor vaccine efficacy mediated by CD8(+) T cells.
- Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice.
- Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody.
- Unsung hero Robert C. Gallo.
- Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice.
- The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation.
- Generation of functionally active HIV-1 specific CD8+ CTL in intestinal mucosa following mucosal, systemic or mixed prime-boost immunization.
- Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines.
- Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses.
- A pilot study of consolidative immunotherapy in patients with high-risk pediatric sarcomas.
- IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells.
- Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17.
- An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.
- Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2.
- IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis.
- NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis.
- Enhanced cell surface expression, immunogenicity and genetic stability resulting from a spontaneous truncation of HIV Env expressed by a recombinant MVA.
- Therapy of advanced established murine breast cancer with a recombinant adenoviral ErbB-2/neu vaccine.
- The role of NKT cells in tumor immunity.
- Cross-regulation between type I and type II NKT cells in regulating tumor immunity: a new immunoregulatory axis.
- Development of smallpox vaccine candidates with integrated interleukin-15 that demonstrate superior immunogenicity, efficacy, and safety in mice.
- Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination.
- A novel functional CTL avidity/activity compartmentalization to the site of mucosal immunization contributes to protection of macaques against simian/human immunodefic...
- Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women.
- Enhancement of CD8+ T cell immunity in the lung by CpG oligodeoxynucleotides increases protective efficacy of a modified vaccinia Ankara vaccine against lethal poxviru...
- Possible therapeutic vaccine strategy against human immunodeficiency virus escape from reverse transcriptase inhibitors studied in HLA-A2 transgenic mice.
- Cellular immune responses to HPV-18, -31, and -53 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles.
- Protective immunity provided by HLA-A2 epitopes for fusion and hemagglutinin proteins of measles virus.
- Intratumoral therapy with IL13-PE38 results in effective CTL-mediated suppression of IL-13Ralpha2-expressing contralateral tumors.
- Combined prophylactic and therapeutic cancer vaccine: enhancing CTL responses to HPV16 E2 using a chimeric VLP in HLA-A2 mice.
- The NS2 protein of human respiratory syncytial virus suppresses the cytotoxic T-cell response as a consequence of suppressing the type I interferon response.
- Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa.
- Characterization of a novel human tumor antigen interleukin-13 receptor alpha2 chain.
- Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-hu...
- CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcriptio...
- Epitope enhancement of a CD4 HIV epitope toward the development of the next generation HIV vaccine.
- Identification and epitope enhancement of a PAX-FKHR fusion protein breakpoint epitope in alveolar rhabdomyosarcoma cells created by a tumorigenic chromosomal transloc...
- Identification of H-2Db-specific CD8+ T-cell epitopes from mouse VEGFR2 that can inhibit angiogenesis and tumor growth.
- A nonclassical non-Valpha14Jalpha18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance.
- Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells.
- Expression of interleukin-4 by recombinant respiratory syncytial virus is associated with accelerated inflammation and a nonfunctional cytotoxic T-lymphocyte response ...
- Immunization with mutant p53- and K-ras-derived peptides in cancer patients: immune response and clinical outcome.
- Early role of CD4+ Th1 cells and antibodies in HER-2 adenovirus vaccine protection against autochthonous mammary carcinomas.
- Unmasking immunosurveillance against a syngeneic colon cancer by elimination of CD4+ NKT regulatory cells and IL-13.
- Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.
- Fixation and cryopreservation of whole blood and isolated mononuclear cells: Influence of different procedures on lymphocyte subset analysis by flow cytometry.
- Peptide vaccines against cancer.
- From genome to vaccine--new immunoinformatics tools for vaccine design.
- Vaccination by genetically modified dendritic cells expressing a truncated neu oncogene prevents development of breast cancer in transgenic mice.
- IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.
- Non-Hodgkin's lymphoma among asthmatics exposed to pesticides.
- Progress on new vaccine strategies against chronic viral infections.
- Protection against lethal vaccinia virus challenge in HLA-A2 transgenic mice by immunization with a single CD8+ T-cell peptide epitope of vaccinia and variola viruses.
- Progress on new vaccine strategies for the immunotherapy and prevention of cancer.
- Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells.
- Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cells.
- Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines.
- Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumo...
- Dendritic cell-induced activation of adaptive and innate antitumor immunity.
- Modeling a safer smallpox vaccination regimen, for human immunodeficiency virus type 1-infected patients, in immunocompromised macaques.
- Epitope-enhanced conserved HIV-1 peptide protects HLA-A2-transgenic mice against virus expressing HIV-1 antigen.
- Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses.
- Cellular immune responses to human papillomavirus (HPV)-16 L1 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles.
- Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity.
- Selective induction of high avidity CTL by altering the balance of signals from APC.
- Rapid induction of apoptosis in CD8+ HIV-1 envelope-specific murine CTLs by short exposure to antigenic peptide.
- Resistance to metastatic disease in STAT6-deficient mice requires hemopoietic and nonhemopoietic cells and is IFN-gamma dependent.
- A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating ...
- Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.
- DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses.
- Pilot trial of tumor-specific peptide vaccination and continuous infusion interleukin-2 in patients with recurrent Ewing sarcoma and alveolar rhabdomyosarcoma: an inte...
- Vaginal type-II mucosa is an inductive site for primary CD8⺠T-cell mucosal immunity.
- Nonhuman Primate Models for HIV/AIDS Vaccine Development.
- Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal C...
- Pre-immature dendritic cells (PIDC) pulsed with HPV16 E6 or E7 peptide are capable of eliciting specific immune response in patients with advanced cervical cancer.
- Mutant KRAS conversion of conventional T cells into regulatory T cells.
Schools
Albert Einstein College of Medicine of Yeshiva University
Doctors Specialties
- Internal Medicine
- Allergy
- Immunology
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
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