Professor, Ophthalmology and Visual Sciences, University of Kentucky College of Medicine
Ophthalmology
Dr. Jayakrishna Ambati, MD
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Dr. Jayakrishna Ambati is an expert in the field of Ophthalmology. He attended State University of New York Downstate Medical Center College of Medicine. He over the years received 8 awards: "NIH Director's Pioneer Award", "Chanchlani Global Vision Research Award", "Elected Member", "Fellow", "Silver Fellow", "Roger Johnson, MD Memorial Award in Macular Degeneration", "Physician Scientist Award" and "Fellow (FAAO)". Jayakrishna Ambati is a published doctor. He has 64 publications published. The most current publication "Ice incubation step allows adherence of archival histological specimens on gelatin-coated slides for TUNEL staining." Jayakrishna Ambati accepts Medicare payments and is registered with Medicare.gov.
Publications
- Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice.
- IL-18 is not therapeutic for neovascular age-related Macular degeneration.
- DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related Macular degeneration.
- Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.
- Immunology of age-related Macular degeneration.
- Targeted Intraceptor Nanoparticle Therapy Reduces Angiogenesis and Fibrosis in Primate and Murine Macular Degeneration.
- Clocking in on diabetic retinopathy.
- Dual suppression of hemangiogenesis and lymphangiogenesis by splice-shifting morpholinos targeting vascular endothelial growth factor receptor 2 (KDR).
- ERK1/2 activation is a therapeutic target in age-related Macular degeneration.
- Engineered silica nanocarriers as a high-payload delivery vehicle for antioxidant enzymes.
- DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88.
- Human IgG1 antibodies suppress angiogenesis in a target-independent manner.
- Intravenous immune globulin suppresses angiogenesis in mice and humans.
- TLR-Independent and P2X7-Dependent Signaling Mediate Alu RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy.
- Ice incubation step allows adherence of archival histological specimens on gelatin-coated slides for TUNEL staining.
- Heterosexual transmission of HIV.
- Postoperative complications of scleral buckling surgery.
- Anterior uveitis associated with intravenous cidofovir use in patients with cytomegalovirus Retinitis.
- Do urinary levels of vascular endothelial growth factor predict proliferative retinopathy?
- Periorbital and orbital cellulitis before and after the advent of Haemophilus influenzae type B vaccination.
- Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the Vitreous of patients with proliferative diabetic retinopathy.
- Diffusion of high molecular weight compounds through sclera.
- Transscleral delivery of bioactive protein to the choroid and retina.
- A window to innate neuroimmunity: toll-like receptor-mediated cell responses in the retina.
- Short-interfering RNAs induce Retinal degeneration via TLR3 and IRF3.
- Age-related Macular degeneration and the other double helix. The Cogan Lecture.
- DICER1 deficit induces Alu RNA toxicity in age-related Macular degeneration.
- Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague.
- The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model.
- Soluble VEGFR-2: an antilymphangiogenic variant of VEGF receptors.
- The multifactorial nature of Retinal vascular disease.
- Triamcinolone crystal size.
- Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2.
- Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.
- CCR3 is a target for age-related Macular degeneration diagnosis and therapy.
- Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth.
- Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1.
- Toll-like receptor 3 and geographic atrophy in age-related Macular degeneration.
- Fifty years later: the disk goes to the prom.
- Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.
- Toward a higher fidelity model of AMD.
- Molecular docking and analysis of interactions between vascular endothelial growth factor (VEGF) and SPARC protein.
- Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization.
- Corneal avascularity is due to soluble VEGF receptor-1.
- CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates.
- Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.
- Drusen complement components C3a and C5a promote choroidal neovascularization.
- Eyelid disease.
- HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines.
- Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization.
- Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo.
- Aquaporin-1 expression is decreased in human and mouse corneal endothelial dysfunction.
- Retinoblastoma with Cataract and ectopia lentis.
- An animal model of age-related Macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice.
- VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced Retinal neovascularization.
- Macrophage depletion inhibits experimental choroidal neovascularization.
- Inhibition of corneal neovascularization by genetic ablation of CCR2.
- Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization.
- Age-related Macular degeneration: etiology, pathogenesis, and therapeutic strategies.
- Sustained inhibition of corneal neovascularization by genetic ablation of CCR5.
- Angiostatin inhibits and regresses corneal neovascularization.
- Age-related eye disease study caveats.
- Transscleral drug delivery to the retina and choroid.
Schools
Suny Downstate Medical Center
Strong Mem Hsp University Rochester
Procedures Preformed
- Cataract Removal Surgery
- Repair of Retinal Detachment or Retinal Tear
- Vitrectomy (incl. Macular Hole Repair)
Conditions Treated
- Cataract
- Drooping Eyelids (Ptosis)
- Drusen
- Floaters
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Doctors Specialties
- Ophthalmology
Accepted Insurances
Awards
- NIH Director's Pioneer Award
- Chanchlani Global Vision Research Award
- Elected Member
- Fellow
- Silver Fellow
- Roger Johnson, MD Memorial Award in Macular Degeneration
- Physician Scientist Award
- Fellow (FAAO)
Education
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Massachusetts Eye & Ear Infirmary -
University of Rochester -
North Shore-Long Island Jewish Health System -
State University of New York Downstate Medical Center College of Medicine
Hospital
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University of Kentucky Albert B. Chandler Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1295845154 |
| Last Name Of The Provider | AMBATI |
| First Name Of The Provider | JAYAKRISHNA |
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