Dean of the Faculty of Medicine, Harvard Medical School; Caroline Shields Walker Professor of Medicine, Beth Israel Deaconess Medical Center
Endocrinology
Dr. Jeff Flier, MD
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Jeff Flier works in the field of Endocrinology. He graduated from Icahn School of Medicine at Mount Sinai. Icahn School of Medicine at Mount Sinai is ranked 20 in research and 62 in primary care medicine Jeff Flier, MD is a published doctor and has 98 publications published. The lastest was: 'Mice lacking melanin-concentrating hormone are hypophagic and lean.'
Publications
- alpha-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors.
- Creating a Nobel culture.
- Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21.
- FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
- Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice.
- Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice.
- Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.
- Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism.
- Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the ...
- Obesity is a fibroblast growth factor 21 (FGF21)-resistant state.
- Lasker lauds leptin.
- Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.
- Gut check: testing a role for the intestinal microbiome in human obesity.
- Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine.
- Health care reform: without a correct diagnosis, there is no cure.
- Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling.
- Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.
- Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B.
- Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.
- Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.
- PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.
- Evidence for constitutive neural cell proliferation in the adult murine hypothalamus.
- What fuels fat.
- Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.
- Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.
- Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.
- The adipocyte as an active participant in energy balance and metabolism.
- Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.
- TLR4 links innate immunity and fatty acid-induced insulin resistance.
- Attenuation of leptin and insulin signaling by SOCS proteins.
- Leptin regulation of the mesoaccumbens dopamine pathway.
- Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.
- Neuroscience. Regulating energy balance: the substrate strikes back.
- Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells.
- Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance.
- AgRP in energy balance: Will the real AgRP please stand up?
- Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin.
- Neurogenesis in the hypothalamus of adult mice: potential role in energy balance.
- Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.
- The gut and energy balance: visceral allies in the obesity wars.
- A good night's sleep: future antidote to the obesity epidemic?
- Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.
- Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes.
- Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.
- Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.
- Neuroscience. The fat-brain axis enters a new dimension.
- Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain.
- Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
- Obesity wars: molecular progress confronts an expanding epidemic.
- Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic ...
- Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.
- Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.
- Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.
- Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.
- Physiology: is brain sympathetic to bone?
- The stomach speaks--ghrelin and weight regulation.
- Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity.
- Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha.
- Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity.
- A transgenic model of visceral obesity and the metabolic syndrome.
- Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regu...
- Divergent roles of SHP-2 in ERK activation by leptin receptors.
- Cell biology. Chewing the fat--ACC and energy balance.
- Obesity and the regulation of energy balance.
- Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance.
- Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling.
- Diabetes. The missing link with obesity?
- SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.
- Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways.
- Editorial: leptin as a therapeutic agent--trials and tribulations.
- Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice.
- Obesity and insulin resistance.
- Leptin.
- Leptin regulation of neuroendocrine systems.
- Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity.
- In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin.
- Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells.
- Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring.
- Leptin, nutrition, and reproduction: timing is everything.
- Pushing the envelope on lipodystrophy.
- ADD-1 provides major new insight into the mechanism of insulin action.
- Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity.
- Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia.
- The role of SOCS-3 in leptin signaling and leptin resistance.
- Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.
- Big deal about a little insulin.
- Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.
- Regulation of neuronal and glial proteins by leptin: implications for brain development.
- Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor.
- Unraveling the central nervous system pathways underlying responses to leptin.
- Mice lacking melanin-concentrating hormone are hypophagic and lean.
- Sex differences in circulating human leptin pulse amplitude: clinical implications.
- Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven...
- Lowered leptin slims immune response.
- Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids.
- Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus.
- Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat.
Schools
Mount Sinai School of Medicine
Mt Sinai
National Institute Of Health
Doctors Specialties
- Endocrinology
Accepted Insurances
Education
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National Institutes of Health Clinical Center -
Mount Sinai School of Medicine -
Icahn School of Medicine at Mount Sinai
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