Associate Professor, Pathology, University of California, Irvine College of Medicine
Pathology
Dr. Jefferson Y. Chan, MD
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Jefferson Y. Chan is an expert in the field of Pathology. He attended University of California San Francisco School of Medicine. University of California San Francisco School of Medicine is one of the top medical schools in the US. University of California San Francisco School of Medicine has a rank of 3 in research and a 3 in primary care Jefferson Chan is a published doctor as well. He has 55 publications published. The latest was: Increased energy expenditure, UCP1 expression and resistance to diet-induced obesity in mice lacking nuclear factor-erythroid-2 related transcription factor-2 (Nrf2).
Publications
- Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.
- Induction of Herpud1 expression by ER stress is regulated by Nrf1.
- Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas.
- Copper is an endogenous modulator of neural circuit spontaneous activity.
- Role of Nrf2 Dysfunction in Uremia-Associated Intestinal Inflammation and Epithelial Barrier Disruption.
- Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress.
- Making light of stress.
- Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin.
- Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation.
- Molecular Imaging of Labile Iron(II) Pools in Living Cells with a Turn-On Fluorescent Probe.
- Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in ...
- Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1.
- Emerging role of nrf2 in adipocytes and adipose biology.
- Reaction-based small-molecule fluorescent probes for chemoselective bioimaging.
- Characterization of nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes.
- Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability.
- Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein ? during adipogenesis.
- The Fbw7 tumor suppressor regulates nuclear factor E2 related factor 1 (Nrf1) transcription factor turnover through proteasome-mediated proteolysis.
- Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration.
- Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes.
- Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner.
- Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human ...
- Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.
- Role of Nrf1 in antioxidant response element-mediated gene expression and beyond.
- Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity.
- Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice.
- Nrf2 protects against As(III)-induced damage in mouse liver and bladder.
- Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes.
- Pharmacogenomic profile of soy isoflavone concentrate in the prostate of Nrf2 deficient and wild-type mice.
- Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.
- Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.
- Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.
- Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
- The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription.
- Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.
- Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.
- Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.
- Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function.
- Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin.
- Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.
- Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.
- Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
- Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia.
- Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress.
- Nrf1 is critical for redox balance and survival of liver cells during development.
- Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.
- Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.
- NADPH oxidase limits innate immune responses in the lungs in mice.
- NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
- Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.
- Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap ''n'' collar) basic leucine zipper transcription factor...
- Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray.
- Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.
- Increased energy expenditure, UCP1 expression and resistance to diet-induced obesity in mice lacking nuclear factor-erythroid-2 related transcription factor-2 (Nrf2).
Schools
University of California At San Francisco
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
- Blue Card PPO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Education
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UCSF -
University of California San Francisco School of Medicine
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