Physician
Cardiology
Dr. Joe A. Ware, MD
Ware is an expert in the field of Cardiology. He studied medicine at Baylor College of Medicine. He over the years received 2 awards: "Elected Member" and "Fellow (FACC)". Ware is a published doctor as well. He has 101 publications published. The latest was: Myb-dependent regulation of thrombospondin 2 expression. Role of mRNA stability.
Publications
- Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance.
- Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug.
- Endothelial cell activation in patients with decompensated heart failure.
- Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration.
- Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)be...
- Inhibition of tumor necrosis factor alpha-mediated NFkappaB activation and leukocyte adhesion, with enhanced endothelial apoptosis, by G protein-linked receptor (TP) l...
- Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein.
- Protein kinase C (PKC) delta regulates PKCalpha activity in a Syndecan-4-dependent manner.
- Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo.
- Biopsy coupled to quantitative immunofluorescence: a new method to study the human vascular endothelium.
- Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration.
- Too many vessels? Not enough? The wrong kind? The VEGF debate continues.
- The thromboxane A2 receptor activates mitogen-activated protein kinase via protein kinase C-dependent Gi coupling and Src-dependent phosphorylation of the epidermal gr...
- Reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of AKT phosphorylation in endothelial cells by thromboxane A(2).
- A pair of ACEs, for openers?
- Endothelial proliferation, migration, and differentiation are blunted by conditionally expressed protein kinase C pseudosubstrate peptides.
- Therapeutic angiogenesis for ischemic heart disease.
- Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2).
- Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein.
- Downregulation of protein kinase cdelta activity enhances endothelial cell adaptation to hypoxia.
- Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo-co...
- Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity.
- Cyclooxygenase inhibitors increase Na-K-2Cl cotransporter abundance in thick ascending limb of Henle's loop.
- Protein kinase Cdelta inhibition of S-phase transition in capillary endothelial cells involves the cyclin-dependent kinase inhibitor p27(Kip1).
- Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors bloc...
- Myb-dependent regulation of thrombospondin 2 expression. Role of mRNA stability.
- Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions.
- c-Myb function in fibroblasts.
- Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cells.
- Differential desensitization of thromboxane A2 receptor subtypes.
- Enhancement of migration by protein kinase Calpha and inhibition of proliferation and cell cycle progression by protein kinase Cdelta in capillary endothelial cells.
- Angiogenesis in ischemic heart disease.
- Comparison of fluorescence polarization immunoassay with liquid chromatography for quantification of procainamide and N-acetylprocainamide in urine.
- Food for starving hearts.
- Mitogen-activated protein kinase and proliferation of human vascular smooth muscle cells.
- Disposition of procainamide in patients with chronic congestive heart failure receiving medical therapy.
- Selective inhibition of thrombin receptor-mediated Ca2+ entry by protein kinase C beta.
- Inhibition of N-acetylation of procainamide and renal clearance of N-acetylprocainamide by para-aminobenzoic acid in humans.
- Diversity of the protein kinase C gene family Implications for cardiovascular disease.
- Requirement for protein kinase C activation in basic fibroblast growth factor-induced human endothelial cell proliferation.
- Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.
- Intravenous cocaine induces platelet activation in the conscious dog.
- Comparison of acetyl coenzyme A:arylamine N-acetyltransferase activity in the liver, kidney, and intestine of male and female rats from three strains.
- Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells.
- Cytoplasmic localization of aequorin loaded into human platelets by a new method.
- Concurrent measurement of platelet ionized calcium concentration and aggregation: studies with the lumiaggregometer.
- The septin CDCrel-1 is dispensable for normal development and neurotransmitter release.
- A solid phase extraction-liquid chromatographic-tandem mass spectrometry method for determination of concentrations of GDC-0941, a small molecule class I phosphatidyli...
- Inhibition of platelet aggregation by verapamil: quantification by in vivo and in vitro techniques.
- Changes in von Willebrand factor during cardiac surgery: effect of desmopressin acetate.
- Synergism of platelet-aggregating agents. Role of elevation of cytoplasmic calcium.
- Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model.
- The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion.
- Measurement of platelet cytoplasmic ionized calcium concentration with aequorin and fluorescent indicators.
- Ionized calcium as an intracellular messenger in blood platelets.
- Measurement of platelet ionized calcium.
- Role of fibrinogen in activation of platelets by artificial surfaces.
- Platelet protein phosphorylation, elevation of cytosolic calcium, and inositol phospholipid breakdown in platelet activation induced by plasmin.
- Measurement of ionized calcium in blood platelets with the photoprotein aequorin. Comparison with Quin 2.
- Platelet-mediated thrombosis in stenosed canine coronary arteries: inhibition by nicergoline, a platelet-active alpha-adrenergic antagonist.
- Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome.
- Adventures in hemostasis. Desmopressin in cardiac surgery.
- Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol.
- Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.
- A prototypic platelet septin and its participation in secretion.
- Cocaine and coronary artery thrombosis.
- Ionized calcium in blood platelets.
- The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice.
- GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.
- Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation.
- Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial.
- A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removal.
- Abnormalities of cytoplasmic Ca2+ in platelets from patients with uremia.
- Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3.
- The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.
- Comparison of the absorption and effect on platelet function of a single dose of n-3 fatty acids given as fish or fish oil.
- Seminars in medicine of the Beth Israel Hospital, Boston. Platelet-endothelium interactions.
- Inhibition of platelet aggregation by oral digoxin and reversal with nifedipine.
- Aequorin detects increased cytoplasmic calcium in platelets stimulated with phorbol ester or diacylglycerol.
- The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source.
- Inhibition of human platelet aggregation and cytoplasmic calcium response by calcium antagonists: studies with aequorin and quin2.
- Dysfunctional platelet membrane receptors: from humans to mice.
- Measurement of intracellular platelet calcium with aequorin and Quin 2.
- Effect of digoxin on ejection fraction in elderly patients with congestive heart failure.
- Bleeding time prolongation with streptokinase and its reduction with 1-desamino-8-D-arginine vasopressin.
- Thrombolytic therapy causes an increase in vascular permeability that is reversed by 1-deamino-8-D-vasopressin.
- Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
- Platelet activation by a synthetic hydrophobic polymer, polymethylmethacrylate.
- Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Ibalpha.
- Cytoplasmic Mg2+ concentration in platelets: implications for determination of Ca2+ with aequorin.
- Correlation of circulating von Willebrand factor levels with cardiovascular hemodynamics.
- Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.
- Mechanistic studies on human platelet isoprenylated protein methyltransferase: farnesylcysteine analogs block platelet aggregation without inhibiting the methyltransfe...
- Platelet activation and subsequent inhibition by plasmin and recombinant tissue-type plasminogen activator.
- Effect of hydralazine on the elimination of antipyrine in the rat.
- Dextromethorphan pretreatment induces antipyrine clearance in the rat.
- Calcium mobilization and glycoprotein IIb-IIIa complex ligands in epinephrine-stimulated platelets.
- Activation of protein kinase C in platelets by epinephrine and A23187: correlation with fibrinogen binding.
- Quasi-simultaneous measurement of ionized calcium and alpha-granule release in individual platelets.
- Response of aequorin-loaded platelets to activators of protein kinase C.
Schools
University of Kansas School of Medicine
Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Elected Member
- Fellow (FACC)
Education
-
Baylor College of Medicine -
University of Texas MD Anderson Cancer Center -
University of Kansas School of Medicine
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