Professor, Pediatrics, University of Iowa College of Medicine
Neonat/Perinatology
Dr. John A. Widness, MD
|
|
Give Review
John Widness is an expert in the field of Neonat/Perinatology. He studied medicine at Duke University School of Medicine. Duke University School of Medicine is one of the top medical schools in the US. Duke University School of Medicine is ranked 8/29 in Research/PrimaryCare. John A. Widness, MD is also published. He has 101 publications published. The lastest publication: "Correction of hemorrhage-induced anemia with intra-amniotic iron in the ovine fetus.'
Publications
- Iron is prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs.
- A Mass Balance-Based Semiparametric Approach to Evaluate Neonatal Erythropoiesis.
- Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates.
- One size will never fit all: the future of research in pediatric transfusion medicine.
- High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria.
- Mean remaining life span: a new clinically relevant parameter to assess the quality of transfused red blood cells.
- Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants.
- Tracking donor RBC survival in premature infants: agreement of multiple populations of biotin-labeled RBCs with Kidd antigen-mismatched RBCs.
- Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion.
- Population pharmacodynamic analysis of erythropoiesis in preterm infants for determining the anemia treatment potential of erythropoietin.
- Multidose optimization simulation of erythropoietin treatment in preterm infants.
- Comparison of red blood cell survival in sheep determined using red blood cells labeled with either biotin at multiple densities or [(14) C]cyanate: validation of a mo...
- Accelerated removal of antibody-coated red blood cells from the circulation is accurately tracked by a biotin label.
- Autologous or Allogeneic: Cord Blood Red Blood Cells Still Are Investigational.
- Receptor-based dosing optimization of erythropoietin in juvenile sheep after phlebotomy.
- Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities.
- Long-term Outcome of Brain Structure in Premature Infants: Effects of Liberal vs Restricted Red Blood Cell Transfusions.
- Pharmacokinetic analysis of continuous erythropoietin receptor activator disposition in adult sheep using a target-mediated, physiologic recirculation model and a trac...
- Pharmacodynamic analysis of stress erythropoiesis: change in erythropoietin receptor pool size following double phlebotomies in sheep.
- Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin.
- Red blood cell (RBC) volume can be independently determined in vivo in the sheep using ovine RBCs labeled at different densities of biotin.
- Acute physiological effects of packed red blood cell transfusion in preterm infants with different degrees of anaemia.
- Evidence of receptor-mediated elimination of erythropoietin by analysis of erythropoietin receptor mRNA expression in bone marrow and erythropoietin clearance during a...
- Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity?
- Erythropoietic response to endogenous erythropoietin in premature very low birth weight infants.
- Red blood cell volume can be independently determined in vitro using sheep and human red blood cells labeled at different densities of biotin.
- Comparison of the Bactec 9240 and BacT/Alert blood culture systems for evaluation of placental cord blood for transfusion in neonates.
- Red cell volume can be accurately determined in sheep using a nonradioactive biotin label.
- Treatment and Prevention of Neonatal Anemia.
- Pathophysiology of Anemia During the Neonatal Period, Including Anemia of Prematurity.
- How fast is too fast? a practice change in umbilical arterial catheter blood sampling using the Iowa Model for Evidence-Based Practice.
- Increased erythropoietin elimination in fetal sheep following chronic phlebotomy.
- Erythrocyte iron incorporation but not absorption is increased by intravenous iron administration in erythropoietin-treated premature infants.
- Long-term neurodevelopmental outcome and brain volume after treatment for hydrops fetalis by in utero intravascular transfusion.
- Sources of amniotic fluid erythropoietin during normoxia and hypoxia in fetal sheep.
- Erythrocyte zinc protoporphyrin is elevated with prematurity and fetal hypoxemia.
- Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants.
- Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitor.
- Reduction in red blood cell transfusions using a bedside analyzer in extremely low birth weight infants.
- Association of single nucleotide polymorphisms in the thrombopoietin-receptor gene, but not the thrombopoietin gene, with differences in platelet count.
- Posttransfusion recovery of stored red blood cells in very low birth weight infants using a hemoglobin balance model.
- Posttransfusion 24-hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants.
- Endogenous and recombinant erythropoietin levels decline in human amniotic fluid and fetal plasma in vitro at 37 degrees C.
- RBCs labeled at two biotin densities permit simultaneous and repeated measurements of circulating RBC volume.
- Renal and placental secretion of erythropoietin during anemia or hypoxia in the ovine fetus.
- Effect of maternal exercise and fetoplacental growth rate on serum erythropoietin concentrations.
- Sequence-based polymorphisms in members of the apoptosis Bcl-2 gene family and their association with hematocrit level.
- Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products.
- Clinical performance of an in-line, ex vivo point-of-care monitor: a multicenter study.
- Cost analysis of a neonatal point-of-care monitor.
- Temporal response of plasma erythropoietin to hemorrhage in the ovine fetus.
- Red cell mass responses to daily erythropoietin and iron injections in the ovine fetus.
- Hematocrit correlates well with circulating red blood cell volume in very low birth weight infants.
- Erythropoietin responses to progressive blood loss over 10 days in the ovine fetus.
- Changes in erythropoietin pharmacokinetics following busulfan-induced bone marrow ablation in sheep: evidence for bone marrow as a major erythropoietin elimination pat...
- Expanded Möbius syndrome.
- Etiology of differences in hematocrit between males and females: sequence-based polymorphisms in erythropoietin and its receptor.
- Receptor-based model accounts for phlebotomy-induced changes in erythropoietin pharmacokinetics.
- Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants.
- A pharmacodynamic analysis of erythropoietin-stimulated reticulocyte response in phlebotomized sheep.
- Clinical performance of an in-line point-of-care monitor in neonates.
- Association of fetal and maternal carboxyhemoglobin levels in normal and Rh-alloimmune pregnancies.
- Phlebotomy overdraw in the neonatal intensive care nursery.
- Adaptive responses during anemia and its correction in lambs.
- Cost-effectiveness of a limited-donor blood program for neonatal red cell transfusions.
- A comparison of nonlinear pharmacokinetics of erythropoietin in sheep and humans.
- Antepartum fetal and maternal carboxyhemoglobin and cotinine levels among cigarette smokers.
- Measurement of red cell survival using biotin-labeled red cells: validation against 51Cr-labeled red cells.
- Measurement of circulating red cell volume using biotin-labeled red cells: validation against 51Cr-labeled red cells.
- Correction of hemorrhage-induced anemia with intra-amniotic iron in the ovine fetus.
- Correction for non-ideal tracer pharmacokinetic disposition by disposition decomposition analysis (DDA).
- Plasma transferrin receptor levels and indices of erythropoiesis and iron status in healthy term infants.
- A tracer interaction method for nonlinear pharmacokinetics analysis: application to evaluation of nonlinear elimination.
- Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity in infants with bronchopulmonary dysplasia.
- Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs.
- Fetal plasma iron and restoration of red blood cell mass after hemorrhage of the ovine fetus.
- Hydroxyl radical generation in oxygen-treated infants.
- The life span of erythrocytes transfused to preterm infants.
- Increased plasma erythropoietin levels in lambs treated with parenteral iron.
- Rhesus isoimmunization: increased hemolysis during early infancy.
- Erythrocyte incorporation and absorption of 58Fe in premature infants treated with erythropoietin.
- Effect of chronic erythropoietin administration on plasma iron in newborn lambs.
- Comment: Epoetin alfa loss with NaCl 0.9% dilution.
- In vivo 125I-erythropoietin pharmacokinetics are unchanged after anesthesia, nephrectomy and hepatectomy in sheep.
- Changing patterns of red blood cell transfusion in very low birth weight infants.
- Maternal smoking and fetal carboxyhaemoglobin and blood gas levels.
- Erythropoietin pharmacokinetics in premature infants: developmental, nonlinearity, and treatment effects.
- Serum erythropoietin levels during infancy: associations with erythropoiesis.
- Decreased fetal erythropoiesis and hemolysis in Kell hemolytic anemia.
- A cost analysis comparing erythropoietin and red cell transfusions in the treatment of anemia of prematurity.
- The hematologic and plasma iron responses to severe fetal hemorrhage in the ovine fetus.
- Effect of intravenous beta-sympathomimetic tocolysis on human fetal serum erythropoietin levels.
- A system approach to pharmacodynamics. Plasma iron mobilization by endogenous erythropoietin in the sheep fetus; evidence of threshold response in spontaneous hypoxemia.
- Erythropoietin in human fetuses with immune hemolytic anemia and hydrops fetalis.
- Restoration of fetal red blood cells and plasma proteins after a moderately severe hemorrhage in the ovine fetus.
- Recombinant human erythropoietin vs transfusions in the treatment of anemia of prematurity. A cost-benefit analysis.
- The relationship between fetal arterial oxygen saturation and heart and skeletal muscle myoglobin concentrations in the ovine fetus.
- Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity.
- Elevated erythropoietin levels in cord blood of newborns with Down''s syndrome.
- Direct relationship of fetal carboxyhemoglobin with hemolysis in alloimmunized pregnancies.
Schools
Duke University
Presby University Hospital
University Hosps
Women Infants Hospital Brown University
Doctors Specialties
- Neonatal Medicine
- Neonat/Perinatology
Accepted Insurances
Education
-
Case Western Reserve University - University Hospitals -
University of Pittsburgh Medical Center -
Duke University School of Medicine
Helpful Reviews
Similar Doctors
|
|
Dr. Ekhard E. Ziegler, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Robert D. Roghair, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Frank H. Morriss Jr., MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. John M. Dagle, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Kara J. Stirling, MD |
|
|
Dr. Herman A. Hein, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Michael J. Acarregui, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Olajide O. Dolapo, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Ashraf A. Baeshu, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Michelle N. Kompare, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Jonathan M. Klein, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Edward F. Bell, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Tarah T. Colaizy, MD
This Doctor is OpenDoctor Recommended.
|