Professor, Medicine, UCSD School of Medicine
Infectious Disease
Dr. John C. Guatelli, MD
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Dr. John C. Guatelli works in the field of Infectious Disease. He attended University of California San Diego School of Medicine. University of California San Diego School of Medicine has a rank of 17 in research and a 19 in primary care Doctor John C. Guatelli, MD is a published doctor and has 74 publications published. The lastest was: 'Virological importance of the protease-cleavage site in human immunodeficiency virus type 1 Nef is independent of both intravirion processing and CD4 down-regulation.'
Publications
- Long-term Persistence of Zoster Vaccine Efficacy.
- Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace BST2 from Sites of Viral Assembly.
- Activities of Transmitted/Founder and Chronic Clade B HIV-1 Vpu and a C-terminal Polymorphism Specifically Affecting Virion Release.
- Effects of interferon-α treatment on anti-HIV-1 intrinsic immunity in vivo.
- Safety of Zoster Vaccine in Elderly Adults Following Documented Herpes Zoster.
- STIMULATION OF NF-κB ACTIVITY BY THE HIV RESTRICTION FACTOR BST2.
- Persistence of the efficacy of zoster vaccine in the shingles prevention study and the short-term persistence substudy.
- HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions.
- HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment.
- Upregulation of BST-2/Tetherin by HIV infection in vivo.
- Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens.
- BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action.
- Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.
- BST-2 mediated restriction of simian-human immunodeficiency virus.
- BST-2/tetherin: a new component of the innate immune response to enveloped viruses.
- Tetherin restricts productive HIV-1 cell-to-cell transmission.
- Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles.
- The Vpu protein: new concepts in virus release and CD4 down-modulation.
- How innate immunity can inhibit the release of HIV-1 from infected cells.
- An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex.
- BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.
- Interactions of viral protein U (Vpu) with cellular factors.
- Antiviral activity of the interferon-induced cellular protein BST-2/tetherin.
- Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking.
- Requirements of the membrane proximal tyrosine and dileucine-based sorting signals for efficient transport of the subtype C Vpu protein to the plasma membrane and in v...
- Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 Nef.
- The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein.
- HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.
- Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via it...
- Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1.
- Evidence against a direct antiviral activity of the proteasome during the early steps of HIV-1 replication.
- Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane.
- The effect of the membrane-proximal tyrosine-based sorting signal of HIV-1 gp41 on viral infectivity depends on sequences within gp120.
- A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay.
- Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif.
- HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment.
- The HIV-1 Nef protein as a target for antiretroviral therapy.
- A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.
- Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes.
- Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity.
- The membrane-proximal tyrosine-based sorting signal of human immunodeficiency virus type 1 gp41 is required for optimal viral infectivity.
- Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutations.
- HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes.
- Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to b...
- Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex.
- Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif.
- Analysis of the SH3-binding region of HIV-1 nef: partial functional defects introduced by mutations in the polyproline helix and the hydrophobic pocket.
- The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC.
- Virological importance of the protease-cleavage site in human immunodeficiency virus type 1 Nef is independent of both intravirion processing and CD4 down-regulation.
- Cell-associated viral RNA expression during acute infection with HIV type 1.
- Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.
- Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy.
- The positive influence of Nef on viral infectivity.
- Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.
- Production and characterization of high-titer stocks of rev-defective HIV-1.
- Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes.
- Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.
- Biological importance and cooperativity of HIV-1 regulatory gene splice acceptors.
- Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.
- The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.
- Tat-independent replication of human immunodeficiency viruses.
- Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro.
- Mechanisms for the inhibition of HIV replication by interferons-alpha, -beta, and -gamma in primary human macrophages.
- The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.
- Study on the dehydrating effect of the red cell Na+/K+-pump in nystatin-treated cells with varying Na+ and water contents.
- Influence of red cell water content on the morphology of sickling.
- Nucleic acid amplification in vitro: detection of sequences with low copy numbers and application to diagnosis of human immunodeficiency virus type 1 infection.
- Alternative splice acceptor utilization during human immunodeficiency virus type 1 infection of cultured cells.
- Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication.
- Use of self-sustained sequence replication amplification reaction to analyze and detect mutations in zidovudine-resistant human immunodeficiency virus.
- Detection of mutations associated with zidovudine resistance in human immunodeficiency virus by use of the polymerase chain reaction.
- Methodologies for in vitro nucleic acid amplification and their applications.
- Ordered appearance of human immunodeficiency virus type 1 nucleic acids following high multiplicity infection of macrophages.
Schools
University of California At San Diego
Ucsd Med Center
University Calif
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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University of California San Diego -
University of California San Diego School of Medicine
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