Physician

Ophthalmology

John H. McVey practices Ophthalmology. He graduated from University of Mississippi School of Medicine. He has 1 awards "Fellow (FAAO)". Doctor John H. McVey, MD is also published. He has 100 publications published. The lastest publication: "Fluid shear stress induction of the tissue factor promoter in vitro and in vivo is mediated by Egr-1.'

Publications

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• AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous haemorrhage.
• Inhibition of Thrombin Receptor Signaling on ?-Smooth Muscle Actin+ CD34+ Progenitors Leads to Repair After Murine Immune Vascular Injury.
• A cluster of basic amino acids in the factor X serine protease mediate surface attachment of adenovirus:FX complexes.
• Nomenclature of genetic variants in hemostasis.
• Codon optimization of human factor VIII cDNAs leads to high-level expression.
• Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors.
• O tissue factor, where art thou?
• Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors.
• Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer.
• Temporal expression of alternatively spliced forms of tissue factor pathway inhibitor in mice.
• FVIIa gene delivery: potential treatment for hemophilia?
• Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting.
• Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer.
• In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46.
• Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells.
• Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.
• Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors.
• Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions.
• Adenovirus serotype 5 hexon mediates liver gene transfer.
• Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p.
• Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.
• The influence of blood on in vivo adenovirus bio-distribution and transduction.
• Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop.
• Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.
• The interface between coagulation and immunity.
• The importance of tissue factor source in the management of Factor VII deficiency.
• Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes.
• Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion...
• Tissue factor initiated blood coagulation.
• Inhibition of coagulation by macromolecular complexes.
• A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.
• Characterisation of blood coagulation factor XI T475I.
• The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products.
• Tissue factor in the myocardium: evidence of roles in haemostasis and inflammation.
• Generation of a polyclonal rabbit anti-mouse tissue factor antibody by nucleic acid immunisation.
• Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.
• The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes.
• Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium.
• Two novel mutations in severe factor VII deficiency.
• Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis.
• Characterisation of lymphocyte responses to Ca2+ in Scott syndrome.
• Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.
• Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.
• 450 million years of hemostasis.
• Your bleeding heart: lessons from low tissue factor expression in mice.
• Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.
• Molecular evolution of the vertebrate blood coagulation network.
• Analysis of the consequences of premature termination codons within factor VIII coding sequences.
• A Tyr346-->Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy.
• The relevance of lowered personal control for patients who have stoma surgery to treat cancer.
• Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins.
• Interferon-gamma modulates prolactin and tissue factor expression in differentiating human endometrial stromal cells.
• Cloning and functional analysis of a phosphopantetheinyl transferase superfamily gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230.
• Stable recombinant expression and characterization of the two haemophilic factor VIII variants C329S (CRM(-)) and G1948D (CRM(r)).
• Domains of invasion organelle proteins from apicomplexan parasites are homologous with the Apple domains of blood coagulation factor XI and plasma pre-kallikrein and a...
• Factor VII deficiency and the FVII mutation database.
• Molecular genetic analysis of factor XI deficiency: identification of five novel gene alterations and the origin of type II mutation in Portuguese families.
• Molecular analysis of the genotype-phenotype relationship in factor VII deficiency.
• An alloantibody recognizing the FVIII A1 domain in a patient with CRM reduced haemophilia A due to deletion of a large portion of the A1 domain DNA sequence.
• Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis.
• Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins.
• Tissue factor pathway.
• Molecular analysis of the ERGIC-53 gene in 35 families with combined factor V-factor VIII deficiency.
• Inhibition of tissue factor-dependent and -independent coagulation by cell surface expression of novel anticoagulant fusion proteins.
• Fluid shear stress induction of the tissue factor promoter in vitro and in vivo is mediated by Egr-1.
• Molecular Analysis in Factor XI Deficiency.
• Expression of hirudin fusion proteins in mammalian cells: a strategy for prevention of intravascular thrombosis.
• Analysis of the F8 gene in individuals with high plasma factor VIII: C levels and associated venous thrombosis.
• Exclusion of the first EGF domain of factor VII by a splice site mutation causes lethal factor VII deficiency.
• The genetic basis of inhibitor development in haemophilia A.
• Coagulation factor VII Gln100 --> Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor bin...
• Characterization of a recent retroposon insertion on mouse chromosome 2 and localization of the cognate parental gene to chromosome 11.
• Human tissue factor pathway inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface.
• Factor VIII gene analysis in Japanese CRM-positive and CRM-reduced haemophilia A patients by single-strand conformation polymorphism.
• Identification of two novel mutations in non-Jewish factor XI deficiency.
• Factor VIIShinjo: a dysfunctional factor VII variant homozygous for the substitution Gln for Arg at position 79.
• Six point mutations that cause factor XI deficiency.
• Surface plasmon resonance studies of the interaction between factor VII and tissue factor. Demonstration of defective tissue factor binding in a variant FVII molecule ...
• Efficient gene transfer into human umbilical vein endothelial cells allows functional analysis of the human tissue factor gene promoter.
• Haemophilia A diagnosis by automated fluorescent DNA detection of ten factor VIII intron 13 dinucleotide repeat alleles.
• Haemophilia A diagnosis by simultaneous analysis of two variable dinucleotide tandem repeats within the factor VIII gene.
• High-level production of human blood coagulation factors VII and XI using a new mammalian expression vector.
• Staden Plus.
• A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site.
• Prolongation of canine intestinal allograft survival with RS-61443, cyclosporine, and prednisone.
• A G-->A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP).
• The chromatin structure of the mouse beta-2-microglobulin locus.
• Haemophilia A diagnosis by analysis of a hypervariable dinucleotide repeat within the factor VIII gene.
• Purification and characterization of factor VII 304-Gln: a variant molecule with reduced activity isolated from a clinically unaffected male.
• Detection and characterisation of two missense mutations at a cleavage site in the factor VIII light chain.
• The molecular genetic analysis of hemophilia A: a directed search strategy for the detection of point mutations in the human factor VIII gene.
• The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester.
• CRM+ haemophilia A due to a missense mutation (372----Cys) at the internal heavy chain thrombin cleavage site.
• Differential regulation by cytokines of constitutive and stimulated secretion of von Willebrand factor from endothelial cells.
• Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse sparc (osteonectin) gene.
• Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene.
• Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region.
• In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.
• Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1.

Schools

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• University Of Mississippi School Of Medicine

• University Med Center

• Chldns Hospital Los Angeles Usc

Procedures Preformed

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• Cataract Removal Surgery
• Dacryocystorhinostomy
• Dacryocystostomy or Dacryocystotomy
• Extraocular Muscle Surgery
• View All

Doctors Specialties

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• Ophthalmology

Accepted Insurances

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Awards

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• Fellow (FAAO)

Education

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• University of Mississippi Medical Center
• University of Mississippi School of Medicine

Drug Facts

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NPI NUMBER		1669477329
NPPES Provider LastName		MCVEY
NPPES Provider FirstName		JOHN
NPPES Provider ZIPCode		392022413
NPPES Provider State		MS
Specialty Description		Ophthalmology
Total Claim Count		406.0
Distinct Opioid Count		1.0
Opioid Claim Count		24.0
Percent Opioid Claims		5.91

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1669477329
Last Name Of The Provider	MCVEY
First Name Of The Provider	JOHN
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