Professor of Laboratory Medicine and Medicine
Infectious Disease
Dr. John M. Griffiss, MD
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John M. Griffiss, MD practices Infectious Disease. He graduated from Yale University School of Medicine. Yale University School of Medicine is a top medical college. Yale University School of Medicine is ranked 7/57 in Research/PrimaryCare. John Griffiss is a published doctor as well. He has 101 publications published. The latest was: Characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae strain F62: instability of transposon Tn1545 delta3 in gonococci and evidence that mu...
Publications
- Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals.
- Urethral exudates of men with Neisseria gonorrhoeae infections select a restricted lipooligosaccharide phenotype during transmission.
- Experimental gonococcal urethritis and reinfection with homologous gonococci in male volunteers.
- CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells.
- Pigment gallstone pathogenesis: slime production by biliary bacteria is more important than beta-glucuronidase production.
- Functional activities and immunoglobulin variable regions of human and murine monoclonal antibodies specific for the P1.7 PorA protein loop of Neisseria meningitidis.
- Neisseria gonorrhoeae coordinately uses Pili and Opa to activate HEC-1-B cell microvilli, which causes engulfment of the gonococci.
- Characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae strain F62: instability of transposon Tn1545 delta3 in gonococci and evidence that mu...
- Neisseria gonorrhoeae that infect men have lipooligosaccharides with terminal N-acetyllactosamine repeats.
- Sialylation of Neisseria meningitidis lipooligosaccharide inhibits serum bactericidal activity by masking lacto-N-neotetraose.
- Immunoprophylaxis against klebsiella and pseudomonas aeruginosa infections. The Federal Hyperimmune Immunoglobulin Trial Study Group.
- Bacterial enzymes can add galactose alpha 1,3 to human erythrocytes and creates a senescence-associated epitope.
- Structural studies of the lipooligosaccharides from Haemophilus influenzae type b strain A2.
- Does ozone alleviate AIDS diarrhea?
- Investigation of the structural heterogeneity of lipooligosaccharides from pathogenic Haemophilus and Neisseria species and of R-type lipopolysaccharides from Salmonel...
- Neuraminic acid is alpha 2-->3 linked in the lipooligosaccharide of Neisseria meningitidis serogroup B strain 6275.
- Distribution of a lipooligosaccharide-specific sialyltransferase in pathogenic and non-pathogenic Neisseria.
- Detection and some properties of the sialyltransferase implicated in the sialylation of lipopolysaccharide of Neisseria gonorrhoeae.
- Isolation and characterization of lipopolysaccharides, lipooligosaccharides, and lipid A.
- The structure of lipooligosaccharide produced by Neisseria gonorrhoeae, strain 15253, isolated from a patient with disseminated infection. Evidence for a new glycosyla...
- Differences in outer membrane characteristics between gallstone-associated bacteria and normal bacterial flora.
- Anti-alpha-galactosyl immunoglobulin A (IgA), IgG, and IgM in human secretions.
- HLA expression by benign and malignant prostatic epithelium: augmentation by interferon-gamma.
- The immune response of children to meningococcal lipooligosaccharides during disseminated disease is directed primarily against two monoclonal antibody-defined epitopes.
- Anti-Gal binds to pili of Neisseria meningitidis: the immunoglobulin A isotype blocks complement-mediated killing.
- Meningococcal group A lipooligosaccharides (LOS): preliminary structural studies and characterization of serotype-associated and conserved LOS epitopes.
- IgA blocks IgM and IgG-initiated immune lysis by separate molecular mechanisms.
- A bactericidal microassay for testing serum sensitivity of Neisseria gonorrhoeae.
- Serum IgA: modulation of complement activation and induction of susceptibility to bacterial dissemination.
- Epidemiological value of lipopolysaccharide and heat-modifiable outer-membrane protein serotyping of group-A strains of Neisseria meningitidis.
- Human immune response to various doses of group Y and W135 meningococcal polysaccharide vaccines.
- Immunological basis of serum resistance of Neisseria gonorrhoeae.
- Epidemic meningococcal disease: synthesis of a hypothetical immunoepidemiologic model.
- Safety and immunogenicity of group Y and group W135 meningococcal capsular polysaccharide vaccines in adults.
- Elaboration of both the group W135 and group Y capsular polysccharides by a single strain of Neisseria meningitidis.
- Antibody-dependent mononuclear cell-mediated antimeningococcal activity. Comparison of the effects of convalescent and postimmunization immunoglobulins G, M, and A.
- Heterogeneity of molecular size and antigenic expression within lipooligosaccharides of individual strains of Neisseria gonorrhoeae and Neisseria meningitidis.
- Immune response of infants and children to disseminated infections with Neisseria meningitidis.
- Influence of age on serogroup distribution of endemic meningococcal disease.
- Vaccination against meningococcal disease.
- Immunological relationship between the capsular polysaccharides of Neisseria meningitidis serogroups Z and 29E.
- Safety and immunogenicity of a group 29E meningococcal capsular polysaccharide vaccine in adults.
- Biologic function of the serum IgA system: modulation of complement-mediated effector mechanisms and conservation of antigenic mass.
- Group A meningococcal disease in the U.S. Pacific Northwest: epidemiology, clinical features, and effect of a vaccination control program.
- Group A meningococcal disease in skid rows: epidemiology and implications for control.
- Immunological cross-reaction between a naturally occurring galactan, agarose, and an LPS locus for immune lysis of Neisseria meningitidis by human sera.
- IgA-dependent, monocyte-mediated, antibacterial activity.
- Adult meningoencephalitis caused by herpesvirus hominis type 2.
- Recurrent meningococcal infection with an antigenically identical strain.
- Relationship of dose to the reactogenicity and immunogenicity of meningococcal polysaccharide vaccines in adults.
- Elaboration of a 3.6-kilodalton lipooligosaccharide, antibody against which is absent from human sera, is associated with serum resistance of Neisseria gonorrhoeae.
- Risk of group A meningococcal disease: bacterial interference and cross-reactive bacteria among mucosal flora.
- Vaccines against encapsulated bacteria: a global agenda.
- IgA deficiency with and without mucosal infections.
- Interaction of serum IgA with complement components: the molecular basis of IgA blockade.
- Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora.
- Instability of expression of lipooligosaccharides and their epitopes in Neisseria gonorrhoeae.
- Use of transformation to construct Neisseria gonorrhoeae strains with altered lipooligosaccharides.
- Results of vaccination in patients with IgA deficiency and/or IgG subclass deficiencies.
- Mucosal and serum immunity following commensal enteric colonization.
- Physical heterogeneity of neisserial lipooligosaccharides reflects oligosaccharides that differ in apparent molecular weight, chemical composition, and antigenic expre...
- Familial properdin deficiency and fatal meningococcemia. Correction of the bactericidal defect by vaccination.
- Bactericidal antibody response of normal human serum to the lipooligosaccharide of Neisseria gonorrhoeae.
- Structure and heterogeneity of the oligosaccharides from the lipopolysaccharides of a pyocin-resistant Neisseria gonorrhoeae.
- Human IgA1 initiates complement-mediated killing of Neisseria meningitidis.
- In vitro differentiation of human-derived Pneumocystis carinii.
- Neisseria lactamica and Neisseria meningitidis share lipooligosaccharide epitopes but lack common capsular and class 1, 2, and 3 protein epitopes.
- Lipooligosaccharides: the principal glycolipids of the neisserial outer membrane.
- Epitope expression of gonococcal lipooligosaccharide (LOS). Importance of the lipoidal moiety for expression of an epitope that exists in the oligosaccharide moiety of...
- Electromorphic characterization and description of conserved epitopes of the lipooligosaccharides of group A Neisseria meningitidis.
- Lipooligosaccharides (LOS) of Neisseria gonorrhoeae and Neisseria meningitidis have components that are immunochemically similar to precursors of human blood group ant...
- Pneumocystis carinii in sputum. Comparable efficacy of screening stains and determination of cyst density.
- The immunochemistry of neisserial LOS.
- Phenotypic variation in epitope expression of the Neisseria gonorrhoeae lipooligosaccharide.
- Stability of expression of Neisseria gonorrhoeae lipooligosaccharides.
- Antigenic and physical diversity of Neisseria gonorrhoeae lipooligosaccharides.
- Immunophysical characterization of human isolates of Serratia marcescens.
- Localization of host immunoglobulin G to the surface of Pneumocystis carinii.
- Structural models for the cell surface lipooligosaccharides of Neisseria gonorrhoeae and Haemophilus influenzae.
- Structural determination of oligosaccharides derived from lipooligosaccharide of Neisseria gonorrhoeae F62 by chemical, enzymatic, and two-dimensional NMR methods.
- The structural basis for pyocin resistance in Neisseria gonorrhoeae lipooligosaccharides.
- Human IgA1 blockade of IgG-initiated lysis of Neisseria meningitidis is a function of antigen-binding fragment binding to the polysaccharide capsule.
- In vitro aggregation of macrophages around human-derived Pneumocystis carinii.
- Expression of paragloboside-like lipooligosaccharides may be a necessary component of gonococcal pathogenesis in men.
- Meningococcal molecular mimicry and the search for an ideal vaccine.
- Lysis of Neisseria gonorrhoeae initiated by binding of normal human IgM to a hexosamine-containing lipooligosaccharide epitope(s) is augmented by strain-specific, prop...
- Endogenous sialylation of the lipooligosaccharides of Neisseria meningitidis.
- Modification by sialic acid of Neisseria gonorrhoeae lipooligosaccharide epitope expression in human urethral exudates: an immunoelectron microscopic analysis.
- Measurement of the human immune response to meningococcal lipooligosaccharide antigens by using serum to inhibit monoclonal antibody binding to purified lipooligosacch...
- In vitro and in vivo modification of Neisseria gonorrhoeae lipooligosaccharide epitope structure by sialylation.
- Correlation of Pneumocystis carinii cyst density with mortality in patients with acquired immunodeficiency syndrome and pneumocystis pneumonia.
- Structural characterization of the cell surface lipooligosaccharides from a nontypable strain of Haemophilus influenzae.
- Detection of antibodies to Pneumocystis carinii in bronchoalveolar lavage fluid by immunoreactivity to Pneumocystis carinii within alveoli, granulomas, and disseminate...
- Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces.
- Ability of gonococcal and meningococcal lipooligosaccharides to clot Limulus amebocyte lysate.
- Sialylation and human neutrophil killing of group C Neisseria meningitidis.
- Effect of exogenous sialylation of the lipooligosaccharide of Neisseria gonorrhoeae on opsonophagocytosis.
- Immunoepidemiology of meningococcal disease in military recruits. II. Blocking of serum bactericidal activity by circulating IgA early in the course of invasive disease.
- The ecology of the genus Neisseria.
- Clinical correlation of strain differentiation of Neisseria gonorrhoeae.
Schools
Yale University
King Co Hospital
University Wash Hospital
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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University of Washington -
Harborview Medical Center -
Yale University School of Medicine
Hospital
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San Francisco VA Medical Center
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