Physician
Oncology
Dr. Jonathan G. Drachman, MD
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Jonathan Drachman works in the field of Oncology. Jonathan Drachman is a published MD. He published 49 publications, including: 'Structure and function of the cytokine receptor superfamily.'
Publications
- Dacetuzumab plus rituximab, ifosfamide, carboplatin and etoposide as salvage therapy for patients with diffuse large B-cell lymphoma relapsing after rituximab, cycloph...
- Pilot study of dacetuzumab in combination with rituximab and gemcitabine for relapsed or refractory diffuse large B-cell lymphoma.
- Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma.
- A novel strategy for generating platelet-like fragments from megakaryocytic cell lines and human progenitor cells.
- Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to Acute myelogenous leukemia and a novel AML1 mutation.
- Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656.
- Role of splenectomy in inherited thrombocytopenias.
- Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors.
- Inherited thrombocytopenia: when a low platelet count does not mean ITP.
- Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs.
- Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation.
- A phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors.
- Guanosine nucleotides regulate hormone binding of insulin receptors.
- Reexamining financial incentives in organ donation: a broad perspective.
- Epidemic hypotension in a dialysis center caused by sodium azide.
- Options for increasing organ donation: the potential role of financial incentives, standardized hospital procedures, and public education to promote family discussion.
- Cord blood units collected at a remote site: a collaborative endeavor to collect umbilical cord blood through the Hawaii Cord Blood Bank and store the units at the Pug...
- Proapoptotic signaling activity of the anti-CD40 monoclonal antibody dacetuzumab circumvents multiple oncogenic transformation events and chemosensitizes NHL cells.
- Increased megakaryocytopoiesis in Lyn-deficient mice.
- Prevention of immunization to D+ red blood cells with red blood cell exchange and intravenous Rh immune globulin.
- X-linked thrombocytopenia caused by a novel mutation of GATA-1.
- Membrane localization is not required for Mpl function in normal hematopoietic cells.
- A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl.
- Autosomal dominant thrombocytopenia: incomplete megakaryocyte differentiation and linkage to human chromosome 10.
- CDP/Cut DNA binding activity is down-modulated in granulocytes, macrophages and erythrocytes but remains elevated in differentiating megakaryocytes.
- Role of thrombopoietin in hematopoietic stem cell and progenitor regulation.
- Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis.
- Thrombopoietin signal transduction requires functional JAK2, not TYK2.
- Thrombopoietin signal transduction: studies from cell lines and primary cells.
- Structure and function of the cytokine receptor superfamily.
- Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.
- A proliferation switch for genetically modified cells.
- Thrombopoietin signal transduction in purified murine megakaryocytes.
- The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.
- Mandatory reporting of occupational Diseases by clinicians.
- The alpha beta monomer of the insulin receptor has hormone-responsive tyrosine kinase activity.
- Increased erythrocyte sedimentation rate and a splenic mass.
- Complete remissions observed in Acute myeloid leukemia following prolonged exposure to lintuzumab: a phase 1 trial.
- In vivo inactivation of MASTL kinase results in thrombocytopenia.
- A randomized, multicenter study to determine the safety and efficacy of the immunoconjugate SGN-15 plus docetaxel for the treatment of non-small cell lung carcinoma.
- X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP).
- The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production.
- FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10.
- Identification and activation of Src family kinases in primary megakaryocytes.
- Gene expression profile of primary human CD34+CD38lo cells differentiating along the megakaryocyte lineage.
- Congenital amegakaryocytic thrombocytopenia in three siblings: molecular analysis of atypical clinical presentation.
- A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma.
- A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic Leukemia.
Schools
Harvard Medical School
University Wa Med Center
Conditions Treated
- Acute Leukemia
- Graft vs Host Disease
- Myelodysplastic Syndromes
- Myeloproliferative Disorders
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Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
- Medicare MCR
Education
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University of Washington
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