Ph.D., M.D. Professor of Pathology and Molecular, Cellular and Developmental Biology
Pathology
Dr. Joseph A. Madri, MD
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Joseph A. Madri is an expert in the field of Pathology. He researched medicine at Indiana University School of Medicine. Indiana University School of Medicine is ranked 45/47 in Research/PrimaryCare. He over the years received 1 awards: "Chugai Award for Meritorious Mentorship & Scholarship from the Amer. Soc. Invest. Pathol.". Joseph Madri is a published doctor as well. He has 67 publications published. The latest was: CD44 Influences Fibroblast Behaviors Via Modulation of Cell-Cell and Cell-Matrix Interactions, Affecting Survivin and Hippo Pathways.
Publications
- CD44 Influences Fibroblast Behaviors Via Modulation of Cell-Cell and Cell-Matrix Interactions, Affecting Survivin and Hippo Pathways.
- Disturbed shear stress reduces Klf2 expression in arterial-venous fistulae in vivo.
- Temporal regulation of venous extracellular matrix components during arteriovenous fistula maturation.
- Adhesion Molecule-Mediated Hippo Pathway Modulates Hemangioendothelioma Cell Behavior.
- Stratified control of IGF-I expression by hypoxia and stress hormones in osteoblasts.
- CD44 Regulation of Endothelial Cell Proliferation and Apoptosis via Modulation of CD31 and VE-cadherin Expression.
- CD44 regulates vascular endothelial barrier integrity via a PECAM-1 dependent mechanism.
- CD44 Deficiency Contributes to Enhanced Experimental Autoimmune Encephalomyelitis: A Role in Immune Cells and Vascular Cells of the Blood-Brain Barrier.
- Short term interactions with long term consequences: modulation of chimeric vessels by neural progenitors.
- Brain regional angiogenic potential at the neurovascular unit during normal aging.
- Characterization of the Natural History of Extracellular Matrix Production in Tissue-Engineered Vascular Grafts during Neovessel Formation.
- Varying Effects of Hemodynamic Forces on Tissue Factor RNA Expression in Human Endothelial Cells.
- Pulsatile to-fro flow induces greater and sustained expression of tissue factor RNA in HUVEC than unidirectional laminar flow.
- Laminar shear, but not orbital shear, has a synergistic effect with thrombin stimulation on tissue factor expression in human umbilical vein endothelial cells.
- GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions.
- Myometrial wound healing post-Cesarean delivery in the MRL/MpJ mouse model of uterine scarring.
- An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice.
- Strain differences in behavioral and cellular responses to perinatal hypoxia and relationships to neural stem cell survival and self-renewal: Modeling the neurovascula...
- VEGF-A and Semaphorin3A: modulators of vascular sympathetic innervation.
- Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury.
- Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future.
- Bone marrow monocyte PECAM-1 deficiency elicits increased osteoclastogenesis resulting in trabecular bone loss.
- Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects.
- Fibroblast-type reticular stromal cells regulate the lymph node vasculature.
- Matrix metalloproteinase 9 facilitates West Nile virus entry into the brain.
- Modeling the neurovascular niche: murine strain differences mimic the range of responses to chronic hypoxia in the premature newborn.
- Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction.
- Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades.
- TNF-alpha induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration.
- Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein kinase Czeta modulates membrane type 1-matrix metalloproteinase in endothelial...
- PECAM-1: a multifaceted regulator of megakaryocytopoiesis.
- MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization.
- PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells.
- Modeling the neurovascular niche: VEGF- and BDNF-mediated cross-talk between neural stem cells and endothelial cells: an in vitro study.
- Gamma delta T cells facilitate adaptive immunity against West Nile virus infection in mice.
- PECAM-1 affects GSK-3beta-mediated beta-catenin phosphorylation and degradation.
- The roles of nitric oxide in murine cardiovascular development.
- Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response.
- A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo.
- Neutrophils lacking platelet-endothelial cell adhesion molecule-1 exhibit loss of directionality and motility in CXCR2-mediated chemotaxis.
- Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia.
- Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response.
- Identification of the regions of PECAM-1 involved in beta- and gamma-catenin associations.
- MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells.
- Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice.
- MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity.
- Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells.
- Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction.
- Histamine inhibits conducted vasodilation through endothelium-derived NO production in arterioles of mouse skeletal muscle.
- Transcriptional up-regulation of endothelial cell matrix metalloproteinase-2 in response to extracellular cues involves GATA-2.
- PECAM-1: old friend, new partners.
- Abolition of arteriolar dilation but not constriction to histamine in cremaster muscle of eNOS-/- mice.
- Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.
- Vascular endothelial growth factor expression, beta-catenin tyrosine phosphorylation, and endothelial proliferative behavior: a pathway for transformation?
- Maternal diabetes: effects on embryonic vascular development--a vascular endothelial growth factor-A-mediated process.
- PECAM-1 promotes beta-catenin accumulation and stimulates endothelial cell proliferation.
- Lack of platelet endothelial cell adhesion molecule-1 attenuates foreign body inflammation because of decreased angiogenesis.
- Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2.
- Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif.
- The evolving roles of cell surface proteases in health and disease: implications for developmental, adaptive, inflammatory, and neoplastic processes.
- Disrupted synaptic development in the hypoxic newborn brain.
- Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium.
- Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium.
- Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system.
- Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice.
- Modeling the neurovascular niche: unbiased transcriptome analysis of the murine subventricular zone in response to hypoxic insult.
Schools
Indiana University School of Medicine
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Awards
- Chugai Award for Meritorious Mentorship & Scholarship from the Amer. Soc. Invest. Pathol.
Education
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Indiana University School of Medicine
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