Professor, Medicine, UCSF School of Medicine
Infectious Disease
Dr. Joseph M. McCune III, MD
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Joseph McCune practices Infectious Disease. He attended Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University has a rank of 18 in research and a 49 in primary care He over the years received 1 awards: "Elected Member". Joseph McCune is also published. He has 96 publications published. The lastest publication: "Eye examination for early diagnosis of disseminated tuberculosis in patients with AIDS.'
Publications
- Eye examination for early diagnosis of disseminated tuberculosis in patients with AIDS.
- Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.
- Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Di...
- Immune mechanisms at the maternal-fetal interface: perspectives and challenges.
- Gut epithelial barrier and systemic inflammation during chronic HIV infection.
- HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increas...
- Myeloid-Lymphoid Ontogeny in the Rhesus Monkey (Macaca mulatta).
- Programmed death 1 expression on CD4+ and CD8+ T cells in treated and untreated HIV disease.
- Distinct functional programming of human fetal and adult monocytes.
- The Kynurenine Pathway of Tryptophan Catabolism, CD4+ T Cell Recovery and Mortality in HIV-infected Ugandans Initiating ART.
- Low Proportions of CD28- CD8+ T cells Expressing CD57 Can Be Reversed by Early ART Initiation and Predict Mortality in Treated HIV Infection.
- Analysis of maternal microchimerism in rhesus monkeys (Macaca mulatta) using real-time quantitative PCR amplification of MHC polymorphisms.
- Composition and Function of T Cell Subpopulations Are Slow to Change Despite Effective Antiretroviral Treatment of HIV Disease.
- Monocyte activation by interferon-α is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.
- Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection.
- Discordance between peripheral and colonic markers of inflammation during suppressive ART.
- Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers.
- Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism.
- Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.
- IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
- Preclinical Evaluation of HIV Eradication Strategies in the Simian Immunodeficiency Virus-Infected Rhesus Macaque: A Pilot Study Testing Inhibition of Indoleamine 2,3-...
- Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.
- From academia to biotechnology - and back.
- Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice.
- A functional variant in FCRl3 is associated with higher FC receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.
- Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythemato...
- Immunosenescence and HIV.
- SIV Replication in the Infected Rhesus Macaque Is Limited by the Size of the Preexisting TH17 Cell Compartment.
- Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists.
- Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase.
- Breaking free of sample size dogma to perform innovative translational research.
- Th17 cells and regulatory T cells in elite control over HIV and SIV.
- Design, construction, and validation of a modular library of sequence diversity standards for polymerase chain reaction.
- A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response.
- At the crossroads between tolerance and aggression: Revisiting the "layered immune system" hypothesis.
- HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers.
- HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells.
- The human fetal immune response to hepatitis C virus exposure in utero.
- Immune Activation, Cd4+ T Cell Counts, and Viremia Exhibit Oscillatory Patterns over Time in Patients with Highly Resistant HIV Infection.
- A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers.
- Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans.
- IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient.
- Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin.
- The role of transplacental microtransfusions of maternal lymphocytes in in utero HIV transmission.
- Can HIV be cured with stem cell therapy?
- Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
- Correlating cellular and molecular signatures of mucosal immunity that distinguish HIV controllers from noncontrollers.
- Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.
- Th17 and regulatory T cells: implications for AIDS pathogenesis.
- IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo.
- Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease.
- Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome.
- Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells.
- Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys.
- Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
- Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization.
- Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy.
- Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero.
- Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.
- Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
- Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.
- HIV-induced changes in T cell signaling pathways.
- Growth hormone enhances thymic function in HIV-1-infected adults.
- Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy.
- Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression.
- Antiviral antibodies are necessary for control of simian immunodeficiency virus replication.
- Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study.
- A plea for justice for jailed medical workers.
- Direct measurement of T-cell receptor repertoire diversity with AmpliCot.
- Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia.
- Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
- Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constr...
- Regulation of T cell responses in the developing human fetus.
- HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruption.
- Increased circulating interleukin-7 levels in HIV-1-infected women.
- Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without anti...
- Enhanced replication of R5 HIV-1 over X4 HIV-1 in CD4(+)CCR5(+)CXCR4(+) T cells.
- Growth hormone-induced stimulation of multilineage human hematopoiesis.
- Multiparameter evaluation of human thymic function: interpretations and caveats.
- Public health. A sound rationale needed for phase III HIV-1 vaccine trials.
- Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunode...
- Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection.
- Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial.
- Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice.
- Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis.
- Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients.
- Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus.
- HIV tropism and CD4+ T-cell depletion.
- CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based ther...
- IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus.
- Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production.
- Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging.
- Higher CD27(+)CD8(+) T Cells Percentages during Suppressive Antiretroviral Therapy Predict Greater Subsequent CD4(+) T Cell Recovery in Treated HIV Infection.
- The Immunologic Effects of Mesalamine in Treated HIV-Infected Individuals with Incomplete CD4+ T Cell Recovery: A Randomized Crossover Trial.
- Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4(+) T cell recovery after the initiation of antiretroviral therapy for HIV disease.
Schools
Weill Cornell Medical College
Doctors Specialties
- Internal Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
Education
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Stanford University -
UCSF -
Weill Cornell Medical College of Cornell University
Hospital
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UCSF Medical Center
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