Astrazeneca Professor, Respiratory and Inflammatory Diseases, Brigham and Women's Hospital

Rheumatology

Austen practices Rheumatology. He went to medical school at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He over the years received 1 awards: "Elected Member". Doctor K F. Austen, MD is also published. He has 101 publications published. The lastest publication: "Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice.'

Publications

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• Licensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis.
• Maturation of mast cell progenitors to mucosal mast cells during allergic pulmonary inflammation in mice.
• B Cells Regulate CD4+ T Cell Responses to Papain following B Cell Receptor-Independent Papain Uptake.
• Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization.
• Mouse Mast Cell Proteases 4 and 5 Mediate Epidermal Injury through Disruption of Tight Junctions.
• Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E4 Ligand.
• Mast Cells Recruited to Mesenteric Lymph Nodes during Helminth Infection Remain Hypogranular and Produce IL-4 and IL-6.
• Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation.
• Developmental origin and functional specialization of mast cell subsets.
• The catalytic architecture of leukotriene c4 synthase with two arginine residues.
• Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes.
• The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.
• GPR17 regulates immune pulmonary inflammation induced by house dust mites.
• T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice.
• The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.
• Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells.
• Innate cells and T helper 2 cell immunity in airway inflammation.
• The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications.
• GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4.
• Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.
• Outbreak of adverse reactions associated with contaminated heparin.
• Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors.
• Contaminated heparin associated with adverse clinical events and activation of the contact system.
• The cysteinyl leukotrienes: where do they come from? What are they? Where are they going?
• Doing what I like.
• Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors.
• Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis.
• Additional functions for the cysteinyl leukotrienes recognized through studies of inflammatory processes in null strains.
• The National Institute of Allergy and Infectious Diseases' Asthma and Allergic Disease Centers: a personal commentary.
• Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung.
• Neutrophil-derived leukotriene B4 is required for inflammatory arthritis.
• Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation.
• Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.
• No audible wheezing: nuggets and conundrums from mouse asthma models.
• Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2.
• Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle.
• Lysophosphatidic acid accelerates the development of human mast cells.
• Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.
• Human leukotriene C(4) synthase at 4.5 A resolution in projection.
• Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice.
• Acceptance of the Kober Medal: It only gets better.
• Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis.
• Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils.
• Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R.
• Leukotriene receptors and aspirin sensitivity.
• Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes.
• Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses.
• CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis.
• Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotrie...
• Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics.
• Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing.
• Mast cell mediation of muscle and pulmonary injury following hindlimb ischemia-reperfusion.
• Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice.
• Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells.
• The diverse roles of mast cells.
• Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase.
• The presence of v-abl-transformed V3 mast cells in the lungs augments pulmonary vascular permeability to acid aspiration.
• A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells.
• gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation.
• Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing.
• T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induc...
• IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production.
• Senescent jejunal mast cells and eosinophils in the mouse preferentially translocate to the spleen and draining lymph node, respectively, during the recovery phase of ...
• Cell-specific transcription of leukotriene C(4) synthase involves a Kruppel-like transcription factor and Sp1.
• Mast-cell responses in the development of asthma.
• The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory recep...
• The biochemical, molecular, and genomic aspects of leukotriene C4 synthase.
• Phospholipase A2 enzymes in eicosanoid generation.
• Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells.
• T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro.
• Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells.
• gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosph...
• Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice.
• Generation of a novel stem cell factor-dependent mast cell progenitor.
• Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis.
• Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells.
• Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B...
• Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibro...
• A newly recognized pathway for the negative regulation of mast cell-dependent hypersensitivity and inflammation mediated by an endogenous cell surface receptor of the ...
• Site-directed mutagenesis of human leukotriene C4 synthase.
• Expression of LTC4 synthase during the development of eosinophils in vitro from cord blood progenitors.
• A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide synthase-2 are functionally linked in the delayed phase of prostaglandin D2 generation in mouse bon...
• Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc recept...
• Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and ...
• The presence of membrane-bound stem cell factor on highly immature nonmetachromatic mast cells in the peripheral blood of a patient with aggressive systemic mastocytosis.
• An intrinsic adrenergic system in mammalian heart.
• Post-transcriptional stabilization by interleukin-1beta of interleukin-6 mRNA induced by c-kit ligand and interleukin-10 in mouse bone marrow-derived mast cells.
• Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connecti...
• Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35.
• Post-transcriptional regulation of chymase expression in mast cells. A cytokine-dependent mechanism for controlling the expression of granule neutral proteases of hema...
• Constitutive production of granulocyte/macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil gra...
• Board requirements versus National Institutes of Health requirements.
• Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse.
• Sorting out the cytokines of asthma.
• IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2.
• Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells.
• Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor.
• Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody.
• The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of...
• Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate.

Schools

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• Harvard Medical School

• Massachusetts General Hospital

• Mill Hill Institute Med Rsch

Doctors Specialties

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• Internal Medicine
• Rheumatology

Accepted Insurances

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Awards

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• Elected Member

Education

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• Massachusetts General Hospital
• Harvard Medical School

Hospital

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• Brigham and Women's Hospital

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